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ベリリウムジブロミド

Beryllium bromide

HCID 82230
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
7787-46-4
標準SMILES
[Be+2].[Br-].[Br-]
InChIKey
PBKYCFJFZMEFRS-UHFFFAOYSA-L
分子式
BeBr2
平均分子量
168.82 g/mol
単同位体質量
166.84886

概要

Beryllium bromide is a bromide of beryllium. Beryllium is a lightweight alkaline earth metal with the atomic number 4. It is a relatively rare element found naturally only combined with other elements in minerals. Bromine is a halogen element with the symbol Br and atomic number 35. Diatomic bromine does not occur naturally, but bromine salts can be found in crustal rock. (L625, L24)

名称と識別子

優先名称
Beryllium bromide
IUPAC
beryllium dibromide
現地名
ベリリウムジブロミド
英語名
beryllium dibromide
分子式
BeBr2
分子量
168.820182

名称と別名

Beryllium dibromideBeryllium bromideBeryllium bromide (BeBr2)UNII-T00751H2J8BEYLLIUM BROMIDEEINECS 232-115-9T00751H2J8BERYLLIUM BROMIDE [MI]DTXSID80999064dibromoberylliumRefChem:119108DTXCID301426040
名称をさらに表示
ベリリウムブロミドベリリウムジブロミド臭化ベリリウムBeryllium bromide.beryllium(+2) cation dibromide
BeBr2UN15667787-46-4beryllium;dibromideSCHEMBL305807PBKYCFJFZMEFRS-UHFFFAOYSA-LDB-253972NS00080832

データベース識別子

CAS
7787-46-4
PubChem CID
82230
DTXSID
DTXSID80999064
UNII
T00751H2J8
EC Number
232-115-9
Nikkaji
J95.337G

物性

構造計算による物性

極性表面積
0 Ų
水素結合供与体数
0
水素結合受容体数
2
回転可能結合数
0
重原子数
3
形式電荷
0
複雑度
0

実験および物理化学的性質

Chemical ClassesMetals -> Beryllium Compounds, Inorganic
Physical DescriptionVery hygroscopic solid; [Merck Index] White odorless powder; [MSDSonline] White needles; [Ullmann]

物理化学的性質

融点
506 · 506-509°; also reported as 488°
沸点
520 ° · bp 520°
比重(密度)
3.465 · 3.465
溶解性
2 O; · very soluble in H2O; soluble in ethanol, pyr
外見
斜方晶
色
orthorhombic crystals, crystalline; hygroscopic
水溶解度
2 O · 非常に溶けやすいH2O [MER06]
比熱容量
0.41 J/ · Cp(crystal): 0.41 J/(g·K), at 25℃
EPAの化学物質情報
Beryllium bromide (BeBr2) (7787-46-4)

化学的性質

化学的特性orthorhombic; very hygroscopic; -80 mesh, 99% purity; enthalpy of fusion 9.80 kJ/mol; made by reaction of Be and Br2 at 500°C–700°C [KIR78] [CER91] [MER06] [CRC10]

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

危険有害性情報

Hazards SummaryAn irritant; May cause skin sensitization; Repeated or prolonged exposure may cause chronic beryllium disease; [MSDSonline] See Bromine. See Beryllium for one additional linked occupational disease.

安全と保護具

Minimum Risk LevelChronic Oral: 0.002 mg/kg/day (Beryllium) (L134)
Threshold Limit Values (TLV)0.00005 [mg/m3], as Be, inhalable fraction
Permissible Exposure Limit (PEL)0.002 [mg/m3], as Be, Ceiling(OSHA) = 0.005 mg/m3, as Be(0.025 mg/m3,as Be,for 30 min.peak per 8-hr shift)
Immediately Dangerous to Life or Health (IDLH)4.0 [mg/m3], as Be

毒性情報

Treatment · 1 件

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Health Effects · 1 件

Acute inhalation of a high level of beryllium can result in a pneumonia-like condition called acute beryllium disease. Chronic inhalation of beryllium can cause an inflammatory reaction in the respiratory system called chronic beryllium disease. Chronic beryllium disease may result in anorexia and weight loss, as well as right side heart enlargement and heart disease in advanced cases. Chronic exposure can also increase the risk of lung cancer. Skin contact with beryllium results in contact dermatitus. Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627, L24, L25)

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Beryllium is absorbed mainly through the lungs, where it enters the bloodstream and is transported throughout the body by binding to prealbumins and gamma-globulins. Beryllium accumulates in lung tissue and the skeleton. It is excreted mainly in the urine. Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626, L25)

用途と製造

Uses · 2 件

Used in organic synthesis; [Ullmann]

Beryllium foil is used in x-ray lithography for making integrated circuits. It is used as a reflector or moderator in nuclear reactions. Beryllium is used in gyroscopes and computer parts. Beryllium bromide has been used as a catalyst for the bromination of several organic molecules (L965, A595).

General Manufacturing InformationBeryllium bromide (BeBr2): INACTIVE
応用分野 · 1 件

使用Beryllium fluoride is used in biochemistry, particularly protein crystallography, since it binds in some of the same ways as phosphate does in human tissues. ADP and beryllium fluoride together tend to bind to ATP sites and inhibit protein action, making

調製方法 · 1 件

製造方法Beryllium bromide has the formula BeBr2. It is very hygroscopic and is soluble in water. It has the molecular weight of 168.821 g/mol. The structure has not been documented. Beryllium bromide can be prepared by reacting Be metal with elemental bromine at temperatures of 500°C–700°C: Be+Br2→BeBr2 Beryllium bromide is also formed when beryllium oxide with HBr in aqueous solution or hydrogen bromide in the gas phase: BeO+2HBr→BeBr2+H2O This bromide compound was first prepared by Wohler (1828) by the action of bromine vapor on the metal and also upon a mixture of carbon and beryllium oxide.Berthemot (1831) obtained it in solution by dissolving the oxide in hydrobromic acid. Humpridge (1883) also prepared it by acting on a mixture of the oxide and carbon with dry bromine. The anhydrous bromide is always obtained by sublimation as colorless white crystals.

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化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
Adverse EffectsFibrogenic - Inducing tissue injury and fibrosis (scarring).
Exposure RoutesOral (L626) ; inhalation (L626) ; dermal (L626)
Toxicity Summary · 1 件

Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a major histocompatability (MHC) class II molecule. This MHC class II-beryllium-peptide complex is recognized by the T lymphocyte receptor, triggering CD4+ T lymphocyte activation and proliferation. The resulting inflammatory response is a cell-mediated process orchestrated by cytokines and results in the formation of (usually pulmonary) granulomas. Beryllium's toxicity may be controlled by the iron-storage protein ferritin, which sequesters beryllium by binding it and preventing it from interacting with other enzymes. Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543, L25, A37, A91)

Signs and Symptoms · 1 件

Chronic beryllium disease causes fatigue, weakness, difficulty breathing, and a persistent dry cough. Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (L626, L627, L24, L25)

Carcinogen Classification1, carcinogenic to humans. (L135)

安全データ

tsca
TSCA listed
ridadr
1566
hazard_class
6.1(b)
packing_group
III

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