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臭化マグネシウム, 無水

Magnesium Bromide

HCID 82241
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基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
7789-48-2
標準SMILES
[Br-].[Br-].[Mg+2]
InChIKey
OTCKOJUMXQWKQG-UHFFFAOYSA-L
分子式
Br2Mg
平均分子量
184.11 g/mol

概要

Magnesium bromide is a chemical compound of magnesium and bromine. It is often used as a mild sedative and as an anticonvulsant for treatment of nervous disorders. Bromine is a halogen element with the symbol Br and atomic number 35. Diatomic bromine does not occur naturally, but bromine salts can be found in crustal rock. (L625, L657)

名称と識別子

優先名称
Magnesium Bromide
IUPAC
magnesium dibromide
現地名
臭化マグネシウム, 無水
英語名
Magnesium bromide
分子式
Br2Mg
分子量
184.11

名称と別名

Magnesium bromide7789-48-2MgBr2RefChem:155178DTXCID9048069232-170-92VC6P60SLNDTXSID7064865Magnesium bromide (MgBr2)Magnesium bromide, anhydrousmagnesiumbromideMagnesium Dibromide;
名称をさらに表示
臭化マグネシウム, 無水臭化マグネシウム無水臭化マグネシウム臭化マグネシウム,無水和物finechemicalMagnesium dibromideMagnesium bromide 98 %magnesiumbromide(mgbr2)Magnesium bromide 7789-48-2Magnesiumbromide,anhydrous,98%
Br2MgMagnesiumbromidmagnesium-bromidemagnesium bromide saltmagnesium(II) bromidestarbld0009615magnesium bromide 6-hydrateSCHEMBL19000

データベース識別子

CAS
7789-48-2
PubChem CID
82241
UNII
2VC6P60SLN
EC Number
232-170-9
Nikkaji
J43.879K

物性

構造計算による物性補完中

極性表面積
0 Ų
水素結合供与体数
0
水素結合受容体数
2
回転可能結合数
0
重原子数
3
形式電荷
0
複雑度
0

実験および物理化学的性質

Chemical ClassesMetals -> Metals, Inorganic Compounds
CosmeticsViscosity controlling
Physical DescriptionHexahydrate: Colorless or white solid; Highly deliquescent; [Merck Index] Hygroscopic solid; [Sigma-Aldrich MSDS]

物理化学的性質

融点
711 °C · 711 °C (lit.)
沸点
1248.47 °C · 1248.47°C (estimate)
比重(密度)
3.72 g/mL · 3.72 g/mL at 25 °C (lit.)
溶解性
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
外見
粉
色
オフホワイト
比重
3.72 · 3.72
水溶解度
2 O · H2O (g/100g): 100.6 (25°C), 125.4 (100°C); 固相, MgBr2 6H2O [KRU93]
Merck
13 · 13,5681
安定性
吸湿性
化粧品成分の機能
粘度制御
InChI
InChI=1S/2BrH.Mg/h2*1H;/q;;+2/p-2
InChIKey
OTCKOJUMXQWKQG-UHFFFAOYSA-L

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 8.2% (4 of 49) of reports.

Warning

H315 (91.8%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

危険有害性情報

Regulatory Information · 2 件

Chemical: Magnesium bromide (MgBr2)

Magnesium bromide (MgBr2): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryA moderate irritant; Targets the CNS and kidney; [Sigma-Aldrich MSDS] See Magnesium chloride. See Bromine.
Hazard Classes and Categories · 2 件

Skin Irrit. 2 (100%)

Skin Irrit. 2 (91.8%)

毒性情報

Treatment · 1 件

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626)

用途と製造

UsesUsed in organic syntheses; Has been used as a therapeutic sedative and anticonvulsant; [Merck Index]
Use ClassificationCosmetics -> Viscosity controlling
General Manufacturing InformationMagnesium bromide (MgBr2): ACTIVE
応用分野 · 3 件

解説MgBr2(184.11).水酸化マグネシウムを臭化水素酸で中和して濃縮すると六水和物が得られる.六水和物は無色の六方晶系針状晶.密度2.00 g cm-3.融点172.4 ℃.臭化マグネシウムは,臭化水素気流中で脱水し,乾燥窒素気流中で熱すると無水物となる.無水物は無色の三方晶系結晶.密度3.72 g cm-3.融点711 ℃,沸点1230 ℃.いずれも潮解性で,水に易溶.エタノール,アンモニアには付加物をつくって溶ける.有機合成,医薬品などに用いられる.[CAS 7789-48-2:MgBr2][CAS 13446-53-2:MgBr2・6H2O]森北出版「化学辞典(第2版)

用途マグネシウムブロマイドはその高い溶解度と化学的安定性のため多くの工業的応用に利用されています例えば有機合成における触媒や反応媒介としてまたは火炎抑制剤としての使用が知られていますさらに高等教育機関や研究所における化学実験において重要な試薬としても用いられます

天然物の起源Magnesium bromide occurs in seawater, some mineral springs, natural brines, inland seas and lakes such as the Dead Sea and the Great Salt Lake, and salt deposits such as the Stassfurt deposits. In seawater, it is the primary source of bromine. By the action of chlorine gas upon seawater or seawater bitterns, bromine is formed. It is an electrolyte component in certain dry cells. In medicine, it is a sedative and anticonvulsant for treatment of nervous disorder. It also is used in organic synthesis forming several addition compounds.

調製方法 · 2 件

関連反応

208 件
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HRID 21566 の反応式
HRID 21566反応物としてuspto-grants-1995_06
HRID 22488 の反応式
HRID 22488反応物としてuspto-grants-1995_06
HRID 30453 の反応式
HRID 30453反応物としてuspto-grants-2008_09
HRID 33039 の反応式
HRID 33039反応物としてuspto-grants-2008_09
HRID 226385 の反応式
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HRID 226437 の反応式
HRID 226437反応物としてuspto-grants-2009_07
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化合物ノート

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その他の操作
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SMILES
[Mg+2].[Br-].[Br-]
CAS データベース
7789 · 7789-48-2(CAS DataBase Reference)
NISTの化学物質情報
Magnesium dibromide(7789-48-2)
EPAの化学物質情報
Magnesium bromide (MgBr2) (7789-48-2)

化学的性質

化学的特性マグネシウムブロマイドは化学式がMgBr2で表される無機化合物ですこの白色または無色の固体は水に非常に溶けやすい特性を持ち多湿環境では吸湿性を示しますマグネシウムブロマイドは主に工業的な用途や化学研究において利用されています

化学的特性Magnesium Bromide is a colorless, very deliquescent crystals or white solid; bitter taste. Soluble in water; slightly soluble in alcohol. It formed by reaction of magnesium carbonate and hydrobromic acid.

Health Effects · 1 件

Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627)

Adverse EffectsNeurotoxin - Other CNS neurotoxin
Exposure RoutesOral (L626) ; inhalation (L626) ; dermal (L626)
Toxicity Summary · 1 件

Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543)

Signs and Symptoms · 1 件

Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (L626, L627)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

安全データ

wgk
1
tsca
TSCA listed
hs_code
28275900
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36
ストレージクラス
11 - Combustible Solids

製造方法Magnesium bromide is prepared by treating MgO with hydrobromic acid and then crystallization above 0.0°C in solution. The product is the hexahydrate salt: MgO+2HBr→MgBr2+H2O→MgBr2·6H2O The anhydrous form may also be prepared by heating the hexahydrate with dry HBr gas. This compound can also be formed directly from the elements: Mg+Br2→MgBr2

純化方法Crystallise it from EtOH or H2O (3.3g/mL). Dry it in a vacuum at ~150o, or heat the hydrate in a stream of HCl. It is very deliquescent. [Ehrlich in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 909 1963.]

上流・下流製品情報

上流原料

水酸化マグネシウムジチオりん酸O,O-ジメチルS-(N-メチルカルバモイルメチル)

下流製品

メトキシマロン酸ジメチル臭化ナトリウム