化工社化工社 化学情報印刷レポート · 研究参考用
テトラリン
1,2,3,4-テトラヒドロナフタレン · ビシクロ[4.4.0]デカ-1,3,5-トリエン · テトラナップ · テトラヒドロナフタレン · テトラヒドロナフタリン · 1,2,3,4-テトラヒドロナフタレン [吸光分析用] · 1,2,3,4‐テトラヒドロナフタレン · テトラリン, IN ISOOCTANE (1000ΜG/ML)
識別子と物理属性
| CAS No. | 119-64-2 |
|---|---|
| 分子式 | C10H12 |
| 平均分子量 | 132.2 g/mol |
| 単同位体質量 | 132.09390038 g/mol |
| SMILES | c1ccc2c(c1)CCCC2 |
| InChIKey | CXWXQJXEFPUFDZ-UHFFFAOYSA-N |
| PubChem CID | 8404 |
| ChEMBL | CHEMBL1575635 |
| ChEBI | CHEBI:35008 |
| EC No. | 204-340-2 |
| DTXSID | DTXSID1026118 |
| 現地名 | テトラリン |
化学・物理的性質
| XLogP | 3.5 |
|---|---|
| 極性表面積 | 0 |
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 0 |
| 回転可能結合数 | 0 |
| 重原子数 | 10 |
| 形式電荷 | 0 |
| 複雑度 | 92.6 |
| 物質分類 | Other Classes -> NaphthalenesVolatile Organic Compound (VOC) |
| pH | ACIDITY NEUTRAL |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| LogP（分配係数） | 3.783.49 |
| 臭い | ODOR RESEMBLING MIXTURE OF BENZENE & MENTHOLMOLDY, TURPENTINE ODORPungent odor刺激的なメントール臭 |
| 密度 | 0.974 at 68 °F (liquid (USCG, 1999) - Less dense than waterwill float0.9702 G/ML @ 20 °C/4 °CMOISTURE CONTENT NONERESIDUE ON EVAPORATION NONEBULK DENSITY 8 LB/GALRelative density (water = 1): 0.97020.981 @25 °C0.973 g/mL at 25 °C (lit.) |
| Viscosity | 2.012 cP @ 25 °C |
| Color/Form | COLORLESS LIQUID |
| 溶解度 | MISCIBLE WITH ETHANOL, BUTANOL, ACETONE, BENZENE, PETROLEUM ETHER, CHLOROFORM, &PETROLEUM ETHER, DECALINSOL IN METHANOL: 50.6% WT/WTINSOL IN WATER.SOL IN ANILINESOL IN ETHERSolubility in water: very poor0.045g/リットル不溶性 |
| 引火点 | 176 °F (USCG, 1999)82 °C171 °F (77 °C) (OPEN CUP)180 °F (82 °C) (CLOSED CUP)160 °F (71 °C) (CLOSED CUP)176 °C (Closed cup)190 °F (Open cup)77 °C o.c. |
| 沸点 | 406 °F at 760 mmHg (USCG, 1999)207.6 °C @ 760 MM HG207.2 °C @760 [mm Hg]207 °C (lit.) |
| Decomposition | UNDER ... PYROLYSIS AT 700 °C, TETRALIN ... YIELDS TARS THAT CONTAIN APPRECIABLE QUANTITIES OF 3,4-BENZOPYRENE. |
| 融点 | -35 °C (lit.) |
| 蒸気密度 | 4.55 (vs air) |
| 蒸気圧 | 0.18 mm Hg ( 20 °C) |
| 屈折率 | n20/D 1.541(lit.) |
| 貯蔵条件 | Store below +30°C. |
| 外観・状態 | 体液 |
| 色 | Colorless |
| 臭気閾値 | 0.0093ppm |
| 爆発限界 | 0.8%, 100°F |
| 比熱容量 | Cp(liquid): 1.65 J/(g·K), at 25℃ |
| Merck | 14,9221 |
| BRN | 1446407 |
| ヘンリー定数 | 6.4×10-3 mol/(m3Pa) at 25℃, Plyasunov and Shock (2000) |
| 誘電率 | 2.77 |
| 安定性 | 安定。可燃性。強力な酸化剤とは相容れない。 |
| InChI | 1S/C10H12/c1-2-6-10-8-4-3-7-9(10)5-1/h1-2,5-6H,3-4,7-8H2 |
| InChIKey | CXWXQJXEFPUFDZ-UHFFFAOYSA-N |
| SMILES | C1CCc2ccccc2C1 |
| LogP（分配係数） | 3.78 at 23℃ |
| CAS データベース | 119-64-2(CAS DataBase Reference) |
| NISTの化学物質情報 | Tetralin(119-64-2) |
| EPAの化学物質情報 | 1,2,3,4-Tetrahydronaphthalene (119-64-2) |
化学的特性
Tetralin or 1,2,3,4-tetrahydronaphthalene is a flammable liquid.
安全性と法規制
| GHS 分類 | WarningH315: Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 1.5% (11 of 729) of reports.DangerH304 (20.3%): May be fatal if swallowed and enters airways [Danger Aspiration hazard] |
|---|---|
| 規制情報 | Chemical: Naphthalene, 1,2,3,4-tetrahydro-Naphthalene, 1,2,3,4-tetrahydro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Naphthalene, 1,2,3,4-tetrahydro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 11-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/210761,2,3,4-Tetrahydronaphthalene: Does not have an individual approval but may be used under an appropriate group standard |
| 輸送ラベル（DOT） | Combustible Liquid |
| 火災危険 | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 77 °C explosive vapour/air mixtures may be formed. |
| 火災の可能性 | MODERATE, WHEN EXPOSED TO HEAT OR FLAMECAN REACT WITH OXIDIZING MATERIALS. SPONTANEOUS HEATING: NO. |
| 健康有害性 | Liquid may cause nervous disturbance, green coloration of urine, and skin and eye irritation (USCG, 1999) |
| 有害性の概要 | Listed in table of Methemoglobinemia-inducing agents: industrial, environmental, and pharmaceutical[Sullivan, p. 729]Tetralin is a skin and mucous membrane irritant. When used in poorly ventilated areas, tetralin may cause central nervous system depression. Ingestion of tetralin has caused green urine and laboratory evidence of liver and kidney injury. [HSDB] A skin, eye, and respiratory tract irritantInhalation of high concentrations may cause CNS effectsMay cause kidney injury[ICSC] |
| 反応性グループ | Hydrocarbons, Aromatic |
| EC 分類 | Symbol: Xi, NR: 19-36/38-51/53S: (2)-26-28-61 |
| Special Reports | BEAUMONT D, WAIGH RDTHE BETA-ADRENOMIMETIC ACTIVITY OF TETRAHYDROISOQUINOLINESAND TETRAHYDRONAPHTHALENES. PROG MED CHEM 18: 45-86 (1981). A REVIEW WITH 155 REFERENCES ON THE BETA-ADRENOMIMETIC ACTIVITY OF 1,2,3,4-TETRAHYDROISOQUINOLINE AND 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES.Nelson NA et alSolvent Nephrotoxicity in Humans and Experimental Animals. Am J Nephrol 10 (1): 10-20 (1990). Evidence from human case reports, epidemiologic studies and animal experiments have suggested that exposure to organic solvents is associated with a wide spectrum of renal disorders, including tubular necrosis, interstitial disease, glomerulonephritis and neoplasia. This review summarizes what is known about solvent induced renal damage in humans and experimental animals, with emphasis on hypothesized mechanisms by which this broad range of disorders may occur. |
| Reactivity Alerts | Peroxidizable Compound |
| Reactivity Profile | TETRAHYDRONAPHTHALENE may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick 1979 p.151-154]. |
| Chemical Dangers | The substance can form explosive peroxides. Decomposes on heating. This produces irritating fumes. Reacts vigorously with oxidants. |
| 消火 | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 応急処置措置 | Fresh air, rest. Refer for medical attention.Rinse skin with plenty of water or shower. Remove contaminated clothes.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . |
| 応急処置 | INGESTION: induce vomitingcall a doctormedical treatment should be aimed at conservation of liver and kidney function. |
| 安全保管 | Separated from strong oxidants. Keep in a well-ventilated room. Well closed. |
| 暴露管理・個人防護 | 2.0 [ppm] |
| 消火手順 | WATER MAY BE INEFFECTIVE ON FIRE. COOL EXPOSED CONTAINERS WITH WATER. |
| 保管条件 | IN GENERAL MATERIALS ... TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS ... SHOULD BE STORED IN COOL ... VENTILATED PLACE, OUT OF ... SUN, AWAY FROM ... FIRE HAZARD ... BE PERIODICALLY INSPECTED & MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED. |
| 非火災時の漏出対応 | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: |
| 漏出処分 | Personal protection: chemical protection suit. Do NOT let this chemical enter the environment. Ventilation. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
| Isolation and Evacuation | Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: |
| Eye Prevention | Wear safety spectacles. |
| 環境中動態 | TERRESTRIAL FATE: If released to soil, adsorption is expected to take place. However, it has been detected in groundwater beneath a municipal landfill(4) and the annual loadings of tetralin in runoff from land in the Canadian Ontario and Great Lakes water basins are estimated to be 1,053 and 2,270 kg/yr, respectively(5). Based on biodegradation half-lives of 4-13 days in aquatic systems(1-3), biodegradation in soil will be important(SRC).AQUATIC FATE: Based on the estimated Henry's Law constant of 1.7X10-3 atm-cu m/mol at 25 °C(2), volatilization half-lives from a model river (1 m deep flowing 1 m/sec and wind velocity of 3 m/sec) and lake (1 m deep) can be estimated to be 4 hours and 5 days, respectively(1,SRC). An estimated Koc value of 1,800(3) suggests a high adsorption potentialfurthermore, tetralin was detected in suspended solids from St. Louis Bay(4). Screening and grab sample tests indicate a biodegradation half-life of 4-13 days in seawater, groundwater, and river water(5-7). Bioconcentration in fish may be important in organisms that cannot metabolize tetralin(8).ATMOSPHERIC FATE: Based on the experimental vapor pressure of 0.368 mm Hg at 25 °C(1), tetralin is expected to exist almost entirely in the vapor phase in the ambient atmosphere(2). Vapor phase tetralin will degrade rapidly in the ambient atmosphere by reaction with photochemically produced hydroxyl radicals with a half-life of about 11 hours(3,SRC). Vapor phase tetralin will also degrade in the ambient atmosphere at night-time by reaction with nitrate radicals with a half-life of about 3.6 days(4-5,SRC). |
| 有害作用 | Neurotoxin - Acute solvent syndrome |
| Signs and Symptoms | Cough. Dizziness. Headache. Nausea. Vomiting. Weakness.Redness. Pain.Pain. Redness. Blurred vision.Abdominal pain. See Inhalation. |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=119-64-2] |
| Effluent Concentrations | Tetralin was identified at a concn range of 13.3-154.3 ng/L in paper-mill effluents being discharged into the Rainy River(1). Tetralin was qualitatively identified in advanced waste treatment water from Lake Tahoe, CA in October of 1974(2). Tetralin was detected at a concn range of 2-58 ug/mL in 5 incinerator effluent extracts(3). Tetralin was detected 1 km from a Volvo assembly plant in Goteborg, Sweden at a concn of 4.6 ug/cu-m on January 14, 1981regional Goteburg air contains less than 0.01 ug/cu-m tetralin(4). Also, 30 ug/cu-m tetralin was detected in air nearby a Saab assembly plant in Sweden on January 19, 1981(4). These data suggest tetralin is released from automobile assembly plants in emissions from solvents used during painting processes(4). Tetralin emission rates from well-tuned radiant and maltuned convective kerosene space heaters ranged from 100-240 ng/kJ(5).Based upon monitoring data of runoff from land, approximately 1,053 and 2,271 kg tetralin/yr are input to the Canadian Lake Ontario and Canadian Great Lakes water basins, respectively(1). Tetralin was detected at a concn of 11 ng/g in wastewater from the petroleum refining industry after dissolved air flotation(2). |
| ICSC Environmental Data | The substance is toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. It is strongly advised not to let the chemical enter into the environment. |
| Soil Adsorption/Mobility | A Koc for tetralin of about 1,800 can be estimated using a structure activity relationship(1). Based on a suggested classification scheme(2), this Koc value suggests that tetralin has low mobility in soil. |
| Atmospheric Concentrations | INDOOR AIR: Tetralin was detected at concns of 10 and 20 ug/cu-m in 2 of 6 indoor air samples taken mostly from homes in northern Italy(1). |
| Human Toxicity Excerpts | ... IN HIGH CONCENTRATIONS, /SRP: CNS DEPRESSANT/ ... .... VAPORS ARE KNOWN TO PRODUCE HEADACHE, NAUSEA, VOMITING, AND IRRITATION OF CONJUNCTIVA AND OF RESPIRATORY TRACT MUCOSA. HIGH CONCENTRATIONS PRODUCE /CNS DEPRESSION/.Dermal exposure to tetralin has caused eczematous dermatitis, but only rarely, and exposure to tetralin fumes in poorly ventilated places has produced /CNS depressant/ effects including marked restless, eye irritation, headache, malaise, asthenia, nausea, and vomiting.A hallmark for tetralin exposure in man is the production of green colored urine. ... Green urine /was reported/ from a man who had ingested 5.7 g of a pigment called di-tetralin. ... Two cases of "tetralin urine" /were reported/ in painters who used tetralin-containing varnishes in a poorly ventilated areathese workers also showed intense irritation of the mucous membranes, profuse lacrimation , headache, and stupor.For more Human Toxicity Excerpts (Complete) data for TETRALIN (12 total), please visit the HSDB record page. |
| Fish/Seafood Concentrations | Tetralin was detected in small mouth bass (Micropterus dolomieui) at a concn of 75.3 ng/g and yellow perch (Perca flavescens) at concns of 73.2 and 34.5 ng/g from the Rainy River which forms an international boundary between the U.S. and Canada(1). |
| Artificial Pollution Sources | Tetralin is released to the environment in emissions from automobile and diesel engines(1), incinerators(2), kerosene space heaters(3), and from automobile assembly plants during painting processes(4). Tetralin is released in effluents from paper-mills(5), petroleum refineries(6), and in advanced waste treatment effluents(7). Tetralin may also be released to surface waters via runoff from land(8). |
| Environmental Biodegradation | DEGRADATION IN SEA WATER BY OIL OXIDIZING MICROORGANISMS: 31% BREAKDOWN AFTER 21 DAYS AT 22 °C IN STOPPERED BOTTLES CONTAINING A 1000 PPM MIXTURES OF ALKANES, CYCLOALKANES, AND AROMATICS.One screening test using sewage seed suggests that tetralin (initial concn of 3-10 ppm) biodegrades slowly in synthetic seawater3, 3, 2, and 3 percent theoretical BOD in 5, 10, 15, and 20 days, respectively(1). However, 0.0124 ppm tetralin was not detected after 10 days of incubation in artificial seawater at 25 °C indicating that tetralin is moderately oxidized(2). An initial concn of 0.0112 ppm tetralin was observed to degrade 100% in 8 days in a groundwater grab sample at 10 °C and pH 8(3). Tetralin (20.1 ppm initial concn) exhibited 18, 40, 58, 65, 70, and 75 percent theoretical CO2 production after 5, 10, 15, 20, 25, and 35 days, respectively, in water from the Ohio River at 22-25 °C and pH 7.2the half-life in this study was 13 days and, after redosing, a half-life of 9 days was observed under the same conditions(4). |
| 水環境危害等級（WGK） | 2 |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | QK3850000 |
| 輸送番号（UN） | UN 3082 9/PG 3 |
| 毒性 | LD50 orally in rats: 2.86 g/kg (Smyth) |
| 税関コード | 2902 90 00 |
| 危険文句（R） | 19-36/38-51/53-65-40 |
| 化審法 | (4)-574 |
| 消防法 | 危-4-3-III |
| 危険表示 | Xi,N,Xn |
| 安全措置（S） | 26-28-61-28A-62-36/37 |
| 危険等級 | 9Aquatic Chronic 2Asp. Tox. 1Carc. 2Eye Irrit. 2Skin Irrit. 2 |
| 包装等級 | III |
| 自然発火温度 | 723 °F |
| 貯蔵分類 | 10 - Combustible liquids |
| 有害物質データ | 119-64-2(Hazardous Substances Data) |
用途
解説
テトラリン，無色の液体．融点－36 ℃，沸点206 ℃．d20 0.971．n20D 1.5410．さらに水素化すればデカリンとなり，酸化すればフタル酸を与える．水に不溶，エタノール，エーテル，ベンゼンなど多くの有機溶媒に可溶．おもに塗料用溶剤として用いられる．森北出版「化学辞典（第2版）
用途
石油製品の硫黄分試験用溶媒。
用途
溶剤(ワックス、レジン、ゴム、ガム等)、ペイント、ワニス等の原料。
用途
塗料溶剤、繊維洗浄剤
使用
1,2,3,4-Tetrahydronaphthalene, is used as an intermediate for organic synthesis, solvent. It is used as a solvent.It is also used for the laboratory synthesis of dry HBr gas.
一般的な説明
A light colored liquid. May be irritating to skin, eyes and mucous membranes. Flash point 100-141°F.
使用用途
テトラリンは、主に、塗料用の溶剤として利用される他、油脂・脂肪・樹脂・ゴム・ロウ・等の溶剤としても用いられています。また、機械部品等の油脂の洗浄剤としても使用可能です。特に、浸透力が大きいため、通常の溶剤では洗浄しにくい細かい部分の洗浄を得意としています。 他にも医薬中間体を作る際の反応溶媒としても用いられています。さらに、水素化することによって、デカリンが生成されるため、その合成原料として利用可能です。その他、臭素と反応することによって、を発生するため、臭化水素の実験室的製造に使用されることもあります。
製法・合成法
調製方法
Tetralin is prepared by the catalytic hydrogenation of naphthalene or during acidic, catalytic hydrocracking of phenanthrene. At 700℃, tetralin yields tars that contain appreciable quantities of 3,4-benzopyrene (172a).
純化方法
Wash tetralin with successive portions of conc H2SO4 until the acid layer is no longer coloured, then wash it with aqueous 10% Na2CO3, and then distilled water. Dry (CaSO4 or Na2SO4), filter, reflux and fractionally distil it under under reduced pressure from sodium or BaO. It can also be purified by repeated fractional freezing. Bass [J Chem Soc 3498 1964] freed tetralin, purified as above, from naphthalene and other impurities by conversion to ammonium tetralin-6-sulfonate. Concentrated H2SO4 (150mL) is added slowly to stirred tetralin (272mL) which is then heated on a water bath for about 2hours for complete solution. The warm mixture, when poured into aqueous NH4Cl solution (120g in 400mL water), gives a white precipitate which, after filtering off, is crystallised from boiling water, washed with 50% aqueous EtOH and dried at 100o. Evaporation of its boiling aqueous solution on a steam bath removes traces of naphthalene. The pure salt (229g) is mixed with conc H2SO4 (266mL) and steam distilled from an oil bath at 165-170o. An ether extract of the distillate is washed with aqueous Na2SO4, and the ether is evaporated, prior to distilling the tetralin from sodium. Tetralin has also been purified via barium tetralin-6-sulfonate, conversion to the sodium salt and decomposed in 60% H2SO4 using superheated steam. [Beilstein 5 H 491, 5 III 1219, 5 IV 1388.]