ラクトース一水和物
4-O-β-D-ガラクトピラノシル-D-グルコース・水和物 · D-ラクトース・水和物 · 乳糖 · L-CYSTEINE HYDROCHLORIDE · MILK SUGAR · Monohydrate Lactose · LACTOSE BP · LACTOSUM MONOHYDRICUM
識別子と物理属性
| CAS No. | 10039-26-6 |
|---|---|
| 分子式 | C12H22O11 |
| 平均分子量 | 342.3 g/mol |
| 単同位体質量 | 342.11621152 g/mol |
| SMILES | OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O |
| InChIKey | GUBGYTABKSRVRQ-XLOQQCSPSA-N |
| PubChem CID | 84571 |
| ChEBI | CHEBI:36219 |
| EC No. | 238-691-8 |
| DTXSID | DTXSID50873004 |
| 現地名 | ラクトース一水和物 |
化学・物理的性質
| XLogP | -4.7 |
|---|---|
| 極性表面積 | 190 |
| 水素結合供与体数 | 8 |
| 水素結合受容体数 | 11 |
| 回転可能結合数 | 4 |
| 重原子数 | 23 |
| 形式電荷 | 0 |
| 複雑度 | 382 |
| 溶解度 | 195 mg/mL at 20 °CH2O: 0.5M at20℃、透明、無色161g/L |
| 融点 | 201 - 202 °C~215 °C (dec.) |
| Physical Description | Solid |
| Collision Cross Section | 186.3 Ų [M+Li]+ [CCS Type: DTMethod: stepped-field]178.6 Ų [M+K]+ |
| 密度 | 500kg/m3 |
| 貯蔵条件 | room temp |
| 外観・状態 | 個体 |
| 色 | white |
| pH | 4.0-6.5 (20°C, 100g/L in water) |
| InChI | InChI=1/C12H22O11.H2O/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H21H2/t3-,4-,5+,6+,7-,8-,9-,10-,11,12+/s3 |
| InChIKey | WSVLPVUVIUVCRA-UBWUDVJHNA-N |
| SMILES | [C@@H]1([C@H](O)[C@H](C(O)O[C@@H]1CO)O)O[C@H]1[C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O.O |&1:0,1,3,7,12,13,15,16,18,r| |
| CAS データベース | 10039-26-6(CAS DataBase Reference) |
化学的特性
White or almost white, crystalline powder.
安全性と法規制
| 規制情報 | Chemical: D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate.alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard |
|---|---|
| その他の安全情報 | IMAP assessments - D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate: Human health tier I assessment |
| F | 3 |
| 水環境危害等級（WGK） | 3 |
| 自然発火温度 | 390°C |
| 貯蔵分類 | 11 - Combustible Solids |
用途
解説
D-グルコース1分子とD-ガラクトース1分子が，グリコシド結合した二糖，C12H22O11．乳汁に特徴的な成分で，すべての哺乳動物の乳汁中に5 ％前後含まれている．
使用
Excipient.
製法・合成法
調製方法
Lactose is a natural disaccharide consisting of galactose and glucose, and is present in the milk of most mammals. Commercially, lactose is produced from the whey of cows’ milk; whey being the residual liquid of the milk following cheese and casein production. Cows’ milk contains 4.4–5.2% lactose; lactose constitutes 38% of the total solid content of milk. a-Lactose monohydrate is prepared by crystallization from supersaturated solutions below 93.5°C. Various crystalline shapes are prism, pyramidal, and tomahawk; these are dependent on the method of precipitation and crystallization. Direct compression grades of a-lactose monohydrate are prepared by granulation/ agglomeration and spray-drying.