Carbarsone｜化工社

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HCID 8480作成日：2026年10月27日

p-ウレイドフェニルアルソン酸

アミビアルソン · アマベバン · アルサンビド · N-(4-アルソノフェニル)尿素 · 4-[(アミノカルボニル)アミノ]フェニルアルソン酸 · 4-(カルバモイルアミノ)フェニルアルソン酸 · カルバルソヌム · 4-ウレイドフェニルアルソン酸

https://huagongshe.com/ja/chemical/8480

p-ウレイドフェニルアルソン酸の分子構造式

識別子と物理属性

CAS No.	121-59-5
分子式	C7H9AsN2O4
平均分子量	260.08 g/mol
単同位体質量	259.977826 g/mol
SMILES	NC(=O)Nc1ccc([As](=O)(O)O)cc1
InChIKey	WWXBHTZSYYGCSG-UHFFFAOYSA-N
PubChem CID	8480
ChEMBL	CHEMBL1331366
ChEBI	CHEBI:94806
EC No.	204-484-6
DTXSID	DTXSID4020246
現地名	p-ウレイドフェニルアルソン酸

化学・物理的性質

極性表面積	113
水素結合供与体数	4
水素結合受容体数	4
回転可能結合数	2
重原子数	14
形式電荷	0
複雑度	256
溶解度	1 to 10 mg/mL at 71.1 °F (NTP, 1992)DMSO (Slightly), Methanol (Slightly, Sonicated)
融点	345 °F (NTP, 1992)174°
Physical Description	Carbarsone appears as white powder or solid. (NTP, 1992)
外観・状態	個体
pKa（酸解離定数）	3.78±0.10(Predicted)
安定性	Hygroscopic
InChI	InChI=1S/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14)
InChIKey	WWXBHTZSYYGCSG-UHFFFAOYSA-N
SMILES	C1([As](O)(O)=O)=CC=C(NC(N)=O)C=C1
EPAの化学物質情報	Carbarsone (121-59-5)

安全性と法規制

GHS 分類	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
規制情報	Restricted substance: Carbarsone
その他の安全情報	IMAP assessments - Arsonic acid, [4-[(aminocarbonyl)amino]phenyl]-: Environment tier I assessment
輸送ラベル（DOT）	Poison
火災危険	Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992)
健康有害性	SYMPTOMS: Symptoms associated with arsenic compounds include irritation of the gastrointestinal tract, nausea, vomiting and diarrhea. In extreme cases, there may be blood in the vomitus and stool, rapid weak pulse, collapse, coma and death.
反応性グループ	Amides and Imides
Reactivity Profile	An acidic salt of an amide. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Air and Water Reactions	Slightly soluble in water.
Hazard Classes and Categories	Acute Tox. 3 (100%)
消火	Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
応急処置	EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

用途

使用

insecticide, cholinesterase inhibitor

一般的な説明

White powder or solid.

非火災時の漏出対応

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Personal Protective Equipment (PPE)	RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

健康影響

Hypovolemia from capillary leakage (third-spacing of fluids) is a common, serious, early effect. Muscle cramps, facial edema, bronchitis, dyspnea, chest pain, dehydration, intense thirst, and fluid-electrolyte disturbances are also common following significant exposures. A garlic-like odor of the breath and feces may also occur. After absorption, arsenic may cause multi-organ failure by inhibiting sulfhydryl-containing enzymes. Encephalopathy, with headache, lethargy, mental confusion, hallucinations, emotional lability, memory loss and delirium may occurseizures, stupor, convulsions, coma, and death may follow within 24 hours of a severe acute exposure. Dysrhythmias (particularly QTc prolongation and torsade de pointes), cardiomyopathy, ARDS, hepatitis, rhabdomyolysis, hemolysis, and renal failure may develop over several days. The sequence of chronic poisoning involves hyperpigmentation, and eczematoid and allergic dermatitis. muscle fasciculationsgross tremorsataxiaincoordinationand mental confusion. Muscular weakness, limb tenderness and difficulty walking may follow. The final phase consists of peripheral sensory neuropathy of the hands and feet. That may be associated with a motor neuropathy as well .

毒性の概要

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carcinogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Signs and Symptoms

Initial signs and symptoms of arsenic ingestion include burning lips, throat constriction and dysphagia, followed by excruciating abdominal pain, hemorrhagic gastritis, gastroenteritis, severe nausea, projectile voting, profuse "rice water-like" diarrhea, with hypovolemia that may result in hypotension and an irregular pulse. The sequence of chronic poisoning involves weakness, anorexia, hepatomegaly, jaundice, and gastrointestinal complaints, followed by conjunctivitis, irritation of the throat and respiratory tract. ther effects of chronic exposure include conjunctivitis with irritation and lacrimationhair, skin and nail changeshyperkeratosis of feet and handsand melanosis, with pigment spots in corneal and conjunctival epithelium. Peripheral nervous system symptoms may include numbness, burning, and tingling of the hands and feetparesthesiastenderness .