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HCID 8490作成日：2026年10月27日

1,3,5-トリニトロヘキサヒドロ-1,3,5-トリアジン

トリメチレントリニトロアミン · サイクロナイト · シクロニット · 1,3,5-トリニトロヘキサヒドロ-s-トリアジン · ヘキソーゲン · ヘキサヒドロ-1,3,5-トリニトロ-s-トリアジン · ヘキサヒドロ-1,3,5-トリニトロ-1,3,5-トリアジン · トリメチレントリニトラミン

https://huagongshe.com/ja/chemical/8490

1,3,5-トリニトロヘキサヒドロ-1,3,5-トリアジン の分子構造式

識別子と物理属性

CAS No.121-82-4
分子式C3H6N6O6
平均分子量222.12 g/mol
単同位体質量222.03488191 g/mol
SMILESO=[N+]([O-])N1CN([N+](=O)[O-])CN([N+](=O)[O-])C1
InChIKeyXTFIVUDBNACUBN-UHFFFAOYSA-N
PubChem CID8490
ChEBICHEBI:24556
EC No.204-500-1
DTXSIDDTXSID9024142
現地名1,3,5-トリニトロヘキサヒドロ-1,3,5-トリアジン

化学・物理的性質

XLogP1.6
極性表面積147
水素結合供与体数0
水素結合受容体数9
回転可能結合数0
重原子数15
形式電荷0
複雑度229
物質分類Other Uses -> ExplosivesCarcinogens
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
農薬Pesticide -> EPA IRIS
LogP（分配係数）log Kow = 0.87
密度1.82 (NIOSH, 2024) - Denser than waterwill sink1.82 g/cu cm at 20 °C1.8 g/cm³1.82 @25 °Cd420 1.82
Color/FormWhite, crystalline powderWhite crystalline solidOrthorhombic crystals from acetone
溶解度Insoluble (NIOSH, 2024)Insoluble in ethanolslightly soluble in etherSlightly soluble in ethyl acetate, methanol, glacial acetic acidpractically insoluble in carbon tetrachloride, carbon disulfideReadily sol in hot aniline, phenol, warm nitric acid.1 g dissolves in 25 mL acetoneIn water, 59.7 mg/L at 25 °C59.75mg/L(25℃)
引火点Explodes (NIOSH, 2024)2℃
沸点276-280 °C363.28°C (rough estimate)
DecompositionWhen heated to decomposition it emits toxic fumes of/nitrogen oxides/.
融点401 °F (NIOSH, 2024)205.5 °CImpure military grades containing about 10% HMX /hexamethylenetetramine, has a melting point of/ about 190 °C.202 °C205-206°
蒸気圧0.0004 mmHg at 230 °F (NIOSH, 2024)4.10X10-9 mm Hg at 20 °Cnegligible0.0004 mmHg at 230 °F0.0004 [mm Hg] @110 °C(230 °F): 0.0004 mmHg0Pa at 20℃
屈折率1.6700 (estimate)
貯蔵条件2-8°C
pKa（酸解離定数）-15.06±0.20(Predicted)
外観・状態無色の結晶
比熱容量Cp(gas): 1.04 J/(g·K), at 25℃
ヘンリー定数4.9×105 mol/(m3Pa) at 25℃, HSDB (2015)
安定性安定性 不安定。爆発的。
LogP（分配係数）0.87 at 23℃
EPAの化学物質情報Cyclonite (121-82-4)

化学的特性

Hexahydro-1,3,5-trinitro-S-triazine is a white crystalline compound.

安全性と法規制

GHS 分類DangerH201 (97.4%): (Deleted) Explosivemass explosion hazard [Danger Explosives]P210, P230, P240, P250, P260, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P308+P316, P316, P319, P321, P330, P332+P317, P361+P364, P362+P364, P370+P380, P372, P373, P401, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 116 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H201: (Deleted) Explosive
規制情報Chemical: 1,3,5-Triazine, hexahydro-1,3,5-trinitro-Hazard Traits - CarcinogenicityNeurotoxicity1,3,5-Triazine, hexahydro-1,3,5-trinitro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3,5-Triazine, hexahydro-1,3,5-trinitro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 23-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/137321,3,5-Triazine, hexahydro-1,3,5-trinitro-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
その他の安全情報IMAP assessments - 1,3,5-Triazine, hexahydro-1,3,5-trinitro-: Human health tier I assessment
輸送ラベル（DOT）Explosive 1.1D
火災危険Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion. Explosive.
火災の可能性Dangerous due to fire ... hazard. /nitrates/
健康有害性Excerpt from NIOSH Pocket Guide for Cyclonite:Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:
有害性の概要

用途

解説

RDX，ヘキソーゲン，シクロナイトなどとも呼ばれ，第2次大戦中に大量に用いられるようになった高性能爆薬。単独では雷管の添装薬に使われている。最も多い用途は，TNTとの2成分爆薬であるシクロトールやコンポジションBとして炸薬とされるものである。またコンポジションAやコンポジションCなどプラスチック結合爆薬やプラスチック爆薬の主成分としても用いられている。 無色の結晶で，融点204℃，結晶比重1.80，水に不溶，アルコール，ベンゼンなどには難溶，アセトンにはわずかに溶け，温フェノールおよび濃硝酸には易溶である。株式会社平凡社 世界大百科事典 第２版について 情報

用途

高性能爆薬(主として軍事用、極少量が産業用)

使用

Cyclonite is a high explosive and principal constituent of plastic bombs. It is preparedby treating hexamethylenetetramine with nitric acid,ammoniumnitrate,andaceticanhydride: It is also used as a rat poison.

一般的な説明

Cyclotrimethylene trinitramine is an explosive. The explosion can be initiated by a sudden shock, high temperature or a combination of the two. The primary hazard is from blast effect and not from flying projectiles and fragments. Under prolonged exposure to heat or fire they can explode.

製法・合成法

純化方法

RDX crystallises from acetone. [Bachmann & Sheehan J Am Chem Soc 71 1842 1949, Beilstein 26 II 5, 26 III/IV 22.] EXPLOSIVE.

RDX stands for Royal Demolition eXplosive. It is also known as cyclonite or hexogen. The chemical name for RDX is 1,3,5-trinitro-1,3,5-triazine. It is a white powder and is very explosive. RDX is used as an explosive and is also used in combination with other ingredients in explosives. Its odor and taste are unknown. It is a synthetic product that does not occur naturally in the environment. It creates fumes when it is burned with other substances.
In subchronic feeding studies of dogs (50 mg/kg/day for 6 weeks), one of seven dogs died, and the others had weight loss and seizures. Methemoglobinemia was not reported. Animals in chronic studies show liver injury. Workers have experienced central nervous system effects including seizures after occupational exposure. [ACGIH]
反応性グループAzo, Diazo, Azido, Hydrazine, and Azide CompoundsNitro, Nitroso, Nitrate, and Nitrite Compounds, Organic
UN 分類UN Hazard Class: 1.1
Special ReportsMILLER KCTOXICITY AND ADVERSE EFFECTS OF RDX: AN ANNOTATED BIBLIOGRAPHY(ORNL-TIRC-73-14): 7 PP (1973). AN ANNOTATED BIBLIOGRAPHY & REVIEW OF THE TOXICITY & ADVERSE EFFECTS OF RDX.Spanggord RJ et alEnvironmental fate studies on certain munition wastewater constituents, Phase III, Part 1 - model validation: Project LSU-7934, Menlo Park, CASRI Int. (1981).U.S. Dept Health & Human Services/Agency for Toxic Substances Disease RegistryToxicological Profile for RDX (1995) NTIS# PB/95/264263National Technical Information Service (NTIS)Plastic Explosive RDX: Cyclotrimethylenetrinitramine. (Latest Citations from the NTIS Bibliographic database). NTIS/PB95-868170 (1995). This bibliography contains citations concerning the properties and handling of plastic explosive RDX.Daniels JI, Knezovich JPHuman Health Risks from TNT, RDX and HMX in Environmental Media and Consideration of the US Regulatory Environment. NTIS/DE95009480 (1995). /Information concerning disposal of unwanted energetic high explosives ... including RDX/.
TSCA 要件Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date 9/29/06Reporting date: 11/28/06.[40 CFR 716.120] Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1,3,5-Triazine, hexahydro-1,3,5-trinitro- is included on this list. Effective date: 9/29/06Sunset date: 11/28/09.
Reactivity AlertsExplosive
消火Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:Use water in large amounts, powder, carbon dioxide. Combat fire from a sheltered position. In case of fire: keep drums, etc., cool by spraying with water.
応急処置措置Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
応急処置Excerpt from NIOSH Pocket Guide for Cyclonite:Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:(General first aid procedures)
安全保管Substance should be kept wet. Fireproof. Well closed. Separated from combustible substances and strong oxidizers. Store in an area without drain or sewer access.
消火手順If material on fire or involved in fire: Dangerously explosive. Do not fight fires in a cargo of explosives. Evacuate area and let burn.Evacuation: If the material is on fire or involved in fire consider evacuation of one (1) mile radius.
保管条件Store only in a permanent magazine. Protect container against physical damage. Store away from initiator explosives. Separate from oxidizing materials, combustibles & sources of heat.
清掃方法After covering the spills with soda ash, mix, & spray with water. Scoop into a bucket of water and let it stand for 2 hr. Neutralize with 6 molar hydrochloric acid ... .Wastewater containing RDX (Cyclonite) was treated by adsorption on activated carbonthe carbon was regenerated by ozonization, which oxidizes the absorbed substance.
非火災時の漏出対応Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:
処分方法SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.The use of ultraviolet-ozone and ultraviolet-oxidant to treat pink water from ammunition plants was evaluated. Dissolved RDX was removed to <1 mg/L with no by products requiring disposal.The feasibility of treating explosive contaminated wastewater using an oxidant (hydrogen peroxide) in conjunction with short wavelength UV light was evaluated. The process achieves high degree of decontamination without troublesome byproducts.The feasibility of treating the wastewaters from site X RDX/HMX manufacturing facilities in aerobic rotating biological contactor was evaluated. The results from the pilot-scale evaluation indicate that 95-100% soluble /biological oxygen oxygen (BOD)/ removal can be achieved and maintained at soluble BOD loading rates of <2.5 lb/1000 cu ft/day.For more Disposal Methods (Complete) data for CYCLONITE (8 total), please visit the HSDB record page.
漏出処分Evacuate danger area! Consult an expert! Remove all ignition sources. Do NOT let this chemical enter the environment.
Preventive MeasuresSRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at the end of shift, but should remain at employee's place of work for cleaning....Floors of sheds and workrooms should be kept scrupulously clean. Special rules about acceptable types of footwear and clothing, and provision of shoe-cleaning mats prevent the bringing of exposed metal fasteners, loose metal and gritty dirt into explosives buildings. ...Smoking and bringing of incendiary equipment into explosive buildings is forbidden. /Explosive substances/For more Preventive Measures (Complete) data for CYCLONITE (16 total), please visit the HSDB record page.
Isolation and EvacuationExcerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:
毒性学的情報CDC-ATSDR Toxicological Profile
TreatmentFollowing oral exposure, symptomatic patients should be given adequate respiratory support during seizures. Monitor liver and renal function tests and urinalysis in patients with significant exposure. Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. Following eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (T36)
Cancer SitesHepatic
相互作用In one study TNT and RDX were coadministered in the feed of rats for 13 weeks. This co-administration potentiated the decrease in body weight gain as compared to RDX alone. TNT antagonized the lethal effects and the hypotriglyceridemia induced by RDX. RDX antagonized the hypercholesterolemia, splenomegaly, testicular atrophy, hepatocytomegaly, degeneration of the seminiferous tubules, and pigmentation of renal cortices induced by TNT. Investigated the effects of a mixture of 10% RDX and 0.32% TNT in dogs, rats, and mice. All three species showed depression of body weight gain, depressed food intake, and alterations in the spleen, liver, and testes at the highest dose levels. However, RDX was not tested alone.Explosive compounds such as TNT and RDX are recalcitrant contaminants often found co-existing in the environment. In order to understand the joint effects of TNT and RDX on earthworms, an important ecological and bioindicator species at the molecular level, we sampled worms (Eisenia fetida) exposed singly or jointly to TNT (50 mg/kg soil) and RDX (30 mg/kg soil) for 28 days and profiled gene expression in an interwoven loop designed microarray experiment using a 4k-cDNA array. Lethality, growth and reproductive endpoints were measured. Sublethal doses of TNT and RDX had no significant effects on the survival and growth of earthworms, but significantly reduced cocoon and juvenile counts. The mixture exhibited more pronounced reproductive toxicity than each single compound, suggesting an additive interaction between the two compounds. In comparison with the controls, we identified 321 differentially expressed transcripts in TNT treated worms, 32 in RDX treated worms, and only 6 in mixture treated worms. Of the 329 unique differentially expressed transcripts, 294 were affected only by TNT, 24 were common to both TNT and RDX treatments, and 3 were common to all treatments. The reduced effects on gene expression in the mixture exposure suggest that RDX might interact in an antagonistic manner with TNT at the gene expression level. The disagreement between gene expression and reproduction results may be attributed to sampling time, absence of known reproduction-related genes, and lack of functional information for many differentially expressed transcripts. A gene potentially related to reproduction (echinonectin) was significantly depressed in TNT or RDX exposed worms and may be linked to reduced fecundity. Sublethal doses of TNT and RDX affected many biological pathways from innate immune response to oogenesis, leading to reduced reproduction without affecting survival and growth. A complex interaction between mixtures of RDX and TNT was observed at the gene expression level that requires further study of the dynamics of gene expression and reproductive activities in E. fetida. These efforts will be essential to gain an understanding of the additive reproductive toxicity between RDX and TNT.
標的器官Hematological (Blood Forming), Hepatic (Liver), Neurological (Nervous System)Eyes, skin, central nervous system
健康影響RDX can cause seizures. Inhalation exposure to RDX can lead to gastrointestinal, hematological, hepatic, and renal effects. (L259)
生態毒性値LC50Species: Daphnia magna (Water flea)Conditions: flow throughConcentration: >15 mg/L for 96 hrSpecies: Lepomis macrochirus (Bluegill)Conditions: static, pH 6.0Concentration: 3.6 mg/L for 96 hr (95% confidence interval: 1.9-6.6 mg/L)Conditions: staticConcentration: 14 mg/L for 24 hr (95% confidence interval: 12-17 mg/L)Concentration: 8.5 mg/L for 48 hr (95% confidence interval: 7.5-9.5 mg/L)For more Ecotoxicity Values (Complete) data for CYCLONITE (9 total), please visit the HSDB record page.
環境中動態TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 42-167 measured in sediment(2), indicate that cyclonite is expected to have high to moderate mobility in soil(SRC). Volatilization of cyclonite from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.1X10-11 atm-cu m/mole(SRC), based upon its vapor pressure, 4.1X10-9 mm Hg(2), and water solubility, 59.7 mg/L(3). Cyclonite is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Cyclonite, at concentrations of 50 or 100 ug/L, was completely removed after 4 days under anaerobic conditions using a sewage sludge inoculum(4). Cyclonite was mineralized by mixed populations of microorganisms under anaerobic conditions when supplemental carbon was provided(2,5)under aerobic conditions, however, when added to 3 different soil samples and incubated for 56 days it was not biodegraded(6).AQUATIC FATE: Based on a classification scheme(1), Koc values of 42-167 measured in sediment(2), indicate that cyclonite is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.1X10-11 atm-cu m/mole(SRC), derived from its vapor pressure, 4.1X10-9 mm Hg(2), and water solubility, 59.7 mg/L(4). According to a classification scheme(5), BCFs of 0.6 in sheepshead minnows(6) to 11 in fathead minnows(7), suggest the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis should not be an important fate process in fresh waters, although cyclonite was hydrolyzed in sea water with 11.6% loss after 112 days(8). In water, the dominant fate of cyclonite is expected to be direct photochemical degradation by sunlightexperimental half-lives of a few weeks are reported in translucent waters(2). Cyclonite was mineralized by mixed populations of microorganisms under anaerobic conditions in systems such as groundwater, lakes and other shallow waters when supplemental carbon was provided(2,9-10)under aerobic conditions, however, biodegradation proceeds very slowly(11).AQUATIC FATE: In an ecosystem study using sediment, characteristic aquatic vegetation, and cyclonite contaminated groundwater from the Milan Ammunition Plant in Milan, TN, the initial cyclonite concentration in groundwater was 1,529 ug/L. Following a 13-day incubation of sediment, autoclaved-sediment, gravel, and autoclaved gravel concentrations of cyclonite were 1,443, 2,606, 3,120, and 2,583 ug/L, respectively(1). Half-lives of 1853 and 771 hours were reported for freshwater/sediment studies using sediments from Brown's lake and University Lake(2).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cyclonite, which has an extrapolated vapor pressure of 4.1X10-9 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase cyclonite may be removed from the air by wet or dry deposition(SRC). Direct photochemical degradation of cyclonite on aerosols may also be an important fate process(2).
有害作用Neurotoxin - Other CNS neurotoxin
暴露経路The substance can be absorbed into the body in hazardous amounts by inhalation and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contactOral (L259)inhalation (L259)dermal (L259)
毒性の概要RDX can get into the lungs after breathing in the fumes of burning RDX or breathing in the dust from powdered RDX. It can also enter the body after ingestion of contaminated water. It may also pass through the skin into the bloodstream or enter through cuts or breaks in the skin. It also blocks electron transport. (T10, L259)
生態毒性抜粋/BIRDS and MAMMALS/ ...An acute lethal dose (ALD) and 14- and 90-day subchronic dietary exposures to RDX were evaluated in a species potentially present at many contaminated sites, i.e., the northern bobwhite (Colinus virginianus). The ALDs for females and males were 187 and 280 mg/kg, respectively. Data from the 14-day dietary trial suggested that RDX exposure inhibited food consumption, weight gain, and egg production. Dietary RDX exposure for 90-days produced a dose-dependant decreasing trend in total feed consumption, total egg production, and hen-housed production parameters./BIRDS and MAMMALS/ Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) transforms anaerobically into N-nitroso compounds: hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine (DNX), and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX). Exposure to these N-nitroso metabolites may occur in areas contaminated with explosives, as anaerobic degradation occurs via some bacteria and is one remediation strategy used for RDX. Few papers report acute oral toxicity and none have evaluated age dependent toxicity of RDX or its N-nitroso metabolites. Median lethal dose (LD50) was determined in deer mice (Peromyscus maniculatus) of three age classifications 21 d, 50 d, and 200 d for RDX, MNX, and TNX using the US EPA up-and-down procedure (UDP). Hexahydro-1,3,5-trinitro-1,3,5-triazine and N-nitroso metabolites caused similar overt signs of toxicity. Median lethal dose for 21 d deer mice were 136, 181, and 338 mg/kg for RDX, MNX, and TNX, respectively. Median lethal dose for 50 d deer mice were 319, 575, and 338 mg/kg for RDX, MNX, and TNX, respectively. Median lethal dose for 200 d deer mice were 158, 542, and 999 mg/kg for RDX, MNX, and TNX, respectively. These data suggest that RDX is the most potent compound tested, and age dependent toxicity may exist for all compounds and could play a role in RDX and RDX N-nitroso metabolite ecological risk evaluation of terrestrial wildlife at RDX contaminated sites./BIRDS and MAMMALS/ Northern bobwhite (Colinus virginianus) were orally exposed via gavage to 0, 0.5, 3, 8, 12, or 17 mg/kg of RDX (1,3,5-trinitro-1,3,5-triazine) in corn oil daily for 14 days to evaluate sublethal effects of this explosive in birds. Mortality occurred at a rates of 100, 67, and 25% for the 17, 12, and 8 mg/kg/day dose groups, respectively. Death was preceded by clonic and tonic convulsions and weight loss caused by gastrointestinal effects. Increases in serum globulin and total leukocytes were observed in the two highest-dose groups. Degeneration of testicular and splenic tissue also was observed. The no-observed-adverse-effects and lowest-observed-adverse-effects levels were determined as 3.0 and 8.0 mg/kg/day, respectively./BIRDS and MAMMALS/ Military activities associated with training have resulted in soil residues of munition compounds and their breakdown products. Often, these areas are valuable habitats used by birds. To evaluate the possibility of adverse effects in birds, the effects from oral exposures of 2,6-dinitrotoluene (2,6-DNT) and 1,3,5-trinitro-1,3,5-triazine (RDX) were tested using a controlled dosing regime in northern bobwhite (Colinus virginianus). Nine groups of birds of mixed sex received either corn oil or 50, 100, 190, or 350 mg 2,6-DNT/kg body weight/day or 20, 80, 125, or 180 mg RDX/kg body weight/day mixed in corn oil via gavage for 14 day. Etiology of disease was markedly different between compounds. Increased RDX exposure caused an inverse relationship to time of death, symptoms including clonic followed by tonic convulsions, and death shortly thereafter. Brain concentrations of RDX postmortem, however, were relatively consistent (mean +/- standard error, 20.5 +/- 2.9 mg/kg tissue). Observations of 2,6-DNT effects included gastrointestinal distress, dehydration, and a reduction in body mass and feed consumption. Together, these data suggest that RDX is more toxic from short, repeated exposures than 2,6-DNT, resulting in central nervous system-related effects, whereas 2,6-DNT causes gastrointestinal disturbances at higher exposures.For more Ecotoxicity Excerpts (Complete) data for CYCLONITE (24 total), please visit the HSDB record page.
DHS Chemicals of Interest (COI)HexoliteA Commercial Grade5000400Explosive chemical that can be released at a facility.
州飲料水ガイドライン(FL) FLORIDA 10 ug/L(ME) MAINE 3 ug/L
連邦飲料水ガイドラインEPA 2 ug/L
職業暴露区分（OEB）B
職業暴露限界（OEL）TWA: 1.5 mg/m3, STEL: 3 mg/m3 [skin]
水環境危害等級（WGK）2
TSCA 収載状態TSCA listed
輸送番号（UN）UN 0483 1.1D (CYCLOTRIMETHYLENE- TRINITRAMINE (CYCLONITEHEXOGENRDX), DESENSITIZED)
毒性LD50 oral in rat: 100mg/kg
税関コード29339900
危険文句（R）11-23/24/25-36/37/38-36-20/21/22-3
危険表示F,T,Xn,E
安全措置（S）16-27-45-36/37-35-26
危険等級1.1D
有害物質データ121-82-4(Hazardous Substances Data)