2,5-ピリジンジカルボン酸ジプロピル

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Keep in suitable, closed containers for disposal.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Offer surplus and non-recyclable solutions to a licensed disposal company; Contaminated packaging: Dispose of as unused product.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:

Eye/face protection: Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection: Handle with gloves.

Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection: Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

EYES: Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for treatment advice. SKIN: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for treatment advice. INHALATION: Move person to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably by mouth-to-mouth if possible. Call a poison control center or doctor for further treatment advice. INGESTION: Call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a physicican or poison control centre.

May cause respiratory tract irritation and skin irritation. May also cause eye irritation. Harmful if swallowed. Rats tolerated MGK-326 in the diet for two years up to 100 mg/kg/day. MGK-326 increased the incidence of liver tumors (males and females) in the 100 mg/kg/day group. The tumor rates in both sexes in the 65 and 250 mg/kg/day groups were comparable to those of the control group. The insect repellent produced increases in the incidence of benign interstitial cell tumors in the testis and benign uterine tumors. Group mean body weights were significantly decreased for males and females at the 1000 mg/kg/day dosage level when compared to the controls. There was no observed teratogenicity.

LC50; Species: Anas platyrhynchos (Mallard duck) age 10 days; diet >5620 ppm for 8 days /98.8% purity/

LC50; Species: Colinus virginianus (Northern Bobwhite quail) age 10 days; diet 5620 ppm for 8 days /98.8% purity/

LD50; Species: Colinus virginianus (Northern Bobwhite quail) age 17 weeks; oral via capsule 1350 mg/kg /98.8% purity/

EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through; Concentration: 18000 ug/L for 48 hr (95% confidence interval: 9300-20000 ug/L); Effect: intoxication, immobilization /99.7% purity/

For more Ecotoxicity Values (Complete) data for Dipropyl isocinchomeronate (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 168(SRC), determined from a structure estimation method(2), indicates that dipropyl isocinchomeronate is expected to have moderate mobility in soil(SRC). Volatilization of dipropyl isocinchomeronate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.1X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Dipropyl isocinchomeronate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 4.92X10-7 mm Hg at 25 °C(3). Dipropyl isocinchomeronate is expected to hydrolyze in moist neutral and alkaline soils(SRC) based on aqueous hydrolysis half-lives of 17 days and 14 hours at pH 7 and pH 9 respectively(3). Biodegradation data in soil were not available(SRC, 2017). Photodegradation may occur on surfaces exposed to sunlight(SRC) since dipropyl isocinchomeronate is decomposed by sunlight(4).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 168(SRC), determined from a structure estimation method(2), indicates that dipropyl isocinchomeronate may adsorb moderately to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.1X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 100(SRC), from a log Kow of 3.57(5) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low to moderate(SRC). Dipropyl isocinchomeronate is stable to hydrolysis at pH 5; however, it does hydrolyze in neutral (pH 7) and alkaline (pH 9) water with half-lives of 17 days and 14 hours, respectively(6). Utilizing the Japanese MITI test, 1% of the Theoretical BOD was reached in 4 weeks indicating the compound is not readily biodegradable, however, the dipropyl isocinchomeronate hydrolyzed during the test forming pyridine-2,5-dicarboxylic acid and the ThBOD applies to the acid(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dipropyl isocinchomeronate, which has a vapor pressure of 4.92X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dipropyl isocinchomeronate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.5 days(SRC), calculated from its rate constant of 6.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase dipropyl isocinchomeronate may be removed from the air by wet and dry deposition(SRC). Dipropyl isocinchomeronate is decomposed by sunlight(4).

IDENTIFICATION AND USE: Dipropyl isocinchomeronate is an insect repellent. It is used on cats, dogs, human body and clothing, horses and pet living/sleeping quarters. HUMAN STUDIES: Dipropyl isocinchomeronate is a probable human carcinogen. ANIMAL STUDIES: Dipropyl isocinchomeronate was fed in diet to mice at 0, 125, 250, 500, 1000 or 2000 mg/kg/day for 13 weeks. Both sexes showed increased relative liver and brain weights. Males showed decreased kidney weights. In rats fed for 104 weeks, increased incidence in hepatocellular and renal cell adenomas and carcinomas, uterine polyps and testicular interstitial cell tumors were observed at 1000 mg/kg. In mice fed for 80 weeks, hepatocellular adenomas (females) and carcinomas in both sexes and alveolar bronchiolar adenomas (males) were observed at 2000 mg/kg. In rat developmental studies, reduced body weight in both sexes at 1000 mg/kg and mild proliferation of portal bile ducts with increased incidence of trace mononuclear cell infiltrate in the portal areas was observed in F0 females and both sexes of F1 at 1000 mg/kg/day. Dipropyl isocinchomeronate was negative for genotoxicity in Salmonella strains TA1535, TA1537, TA1538, TA98 and TA100 with and without metabolic activation.

Not known.

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of May 1, 2017: http://actor.epa.gov/dashboard/]

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for 2,5-pyridinedicarboxylic acid, dipropyl ester is available.[Available from, as of April 21, 2017: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

Using a structure estimation method based on molecular connectivity indices(1), the Koc of dipropyl isocinchomeronate can be estimated to be 168(SRC). According to a classification scheme(2), this estimated Koc value suggests that dipropyl isocinchomeronate is expected to have moderate mobility in soil.

Dipropyl isocinchomeronate's production and use as an insect repellent for use on both humans and animals(1) may result in its release to the environment through various waste streams(SRC). Commonly used spray and aerosol application of insect repellents containing dipropyl isocinchomeronate will release the compound directly to the environment(SRC). Dipropyl isocinchomeronate is never used as the sole active ingredient, and is commonly formulated with DEET (N,N-diethyl-m-toluamide) and other active insect repellent ingredients(1). Dipropyl isocinchomeronate improves the performance of DEET by slowing its evaporation and doing a better job of repelling various insects such as horse flies, stable flies and specific mosquitoes(2). Personal repellent products are washed off the human body and released in household wastewater into a treatment plant(1). Similarly, those products that are used as surface sprays of animal premises and pet dips would be discharged as wastewater, often to septic systems or sewage treatment plants(1).

AEROBIC: Dipropyl isocinchomeronate, present at 100 mg/L, reached 1% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). However, the dipropyl isocinchomeronate hydrolyzed to form pyridine-2,5-dicarboxylic acid and the 1% theoretical BOD in 4 weeks actually applies to the pyridine-2,5-dicarboxylic acid(1).

An estimated BCF of 100 was calculated in fish for dipropyl isocinchomeronate(SRC), using a log Kow of 3.57(1) and a regression-derived equation(2). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate to high(SRC), provided the compound is not metabolized by the organism(SRC). Although stable to aqueous hydrolysis at pH 5, dipropyl isocinchomeronate has hydrolysis half-lives of 17 days and 14 hours at pH7 and pH9, respectively(3), which will attenuate bioconcentration(SRC). In biodegradation studies using the Japanese MITI test protocol, dipropyl isocinchomeronate hydrolyzed to pyridine-2,5-dicarboxylic acid, and resulting bioconcentration tests using carp (Cyprinus carpio) which were exposed over an 6-week period determined BCF values of 0.3-8.6 for the pyridine-2,5-dicarboxylic acid(4).

The Agency has completed its assessment of the residential risks associated with the use of MGK Repellent 326 repellency products. Based on a review of these data and public comments on the Agency's risk assessments for the active ingredient MGK Repellent 326, EPA has sufficient information on the human health and ecological effects of MGK Repellent 326 to make a reregistration decision under FIFRA, as amended by FQPA. The Agency has determined that MGK Repellent 326 is eligible for reregistration provided that: (i) current data gaps and additional data needs are addressed; and (ii) the risk mitigation measures outlined in this document are adopted, including the label amendments described in Section IV and limiting production and distribution to 20,000 pounds of active ingredient annually by all registrants for use as an insect repellent on humans. The technical registrant(s) must also submit an annual report certifying that production and distribution of MGK Repellent 326 for use in personal insect repellents did not exceed 20,000 lbs a.i.; and (iii) limits the maximum concentration active ingredient in end-use products for personal insect repellents to 2.5%.[USEPA/Office of Prevention, Pesticides and Toxic Substances; Reregistration Eligibility Decision Document for Di-n-propyl isocinchomeronate (MGK Repellent 326)

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Dipropyl isocinchomeronate is found on List B. Case No: 2215; Pesticide type: insecticide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): di-n-propyl isocinchomeronate; Data Call-in (DCI) Date(s): 06/07/91; 08/08/93; 04/19/94/; 10/13/95; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner..