2-アミノベンゾチアゾール

Nitrogen Compounds -> Thiazoles

Dye

PLATES FROM WATER

LEAFLETS FROM WATER

less than 1 mg/mL at 66 °F (NTP, 1992)

SLIGHTLY SOL IN WATER

SOL IN ALCOHOL, ETHER, CHLOROFORM

270 °F (NTP, 1992)

132 °C

2-aminobenzothiazole is an odorless gray to white powder. (NTP, 1992)

Gray to white odorless solid; [CAMEO] Off-white crystalline powder; [Alfa Aesar MSDS]

128.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID1024467]

128.6 Ų [M+H]+

This chemical does not meet GHS hazard criteria for 2.9% (3 of 103) of reports.

Warning

H302 (97.1%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P273, P280, P301+P317, P305+P351+P338, P330, P337+P317, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 103 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: 2-Benzothiazolamine

2-Benzothiazolamine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 1600(SRC), determined from a structure estimation method(2), indicates that 2-aminobenzothiazole will have low mobility in soil(SRC). Volatilization of 2-aminobenzothiazole from moist soil surfaces is not expected to occur(SRC) given an estimated Henry's Law constant of 1.3X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(3). The potential for volatilization of 2-aminobenzothiazole from dry soil surfaces may not exist(SRC) based on an estimated vapor pressure of 1.1X10-4 mm Hg(SRC), determined from a fragment constant method(4).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 1600(SRC), determined from a structure estimation method(2), indicates that 2-aminobenzothiazole should adsorb to suspended solids and sediment in water(SRC). 2-Aminobenzothiazole is not expected to volatilize from water surfaces(1,SRC) based on an estimated Henry's Law constant of 1.3X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). According to a classification scheme(5), an estimated BCF value of 19(1,SRC), from an estimated log Kow(4,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Biodegradation of 2-aminobenzothiazole in aquatic systems is not expected to occur(6).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-aminobenzothiazole, which has an estimated vapor pressure of 1.1X10-4 mm Hg at 25 °C(2,SRC), will exist solely in the vapor phase in the ambient atmosphere. Vapor-phase 2-aminobenzothiazole is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 0.64 hours(3,SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2-aminobenzothiazole can be estimated to be about 1600(SRC). According to a recommended classification scheme(2), this estimated Koc value suggests that 2-aminobenzothiazole has low mobility in soil(SRC).

2-Aminobenzothiazole's use in azo dye production and in photographic chemicals(1) may result in its release to the environment through various waste streams(SRC). 2-Aminobenzothiazole may be introduced into soils as a result of the breakdown of the herbicide methabenzthiazuron(2).

A biodegradation study of 2-aminobenzothiazole, based on COD measurements, using an activated sludge seed, and an initial concentration of 100mg/l 2-aminobenzothiazole indicated no biodegradation of 2-aminobenzothiazole over a period of 30 days(1).

An estimated BCF value of 19 was calculated for 2-aminobenzothiazole(SRC), using an estimated log Kow of 2.0(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for 2-aminobenzothiazole is estimated as 1.3X10-10 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that 2-aminobenzothiazole will be essentially nonvolatile from water surfaces(2,SRC).

The rate constant for the vapor-phase reaction of 2-aminobenzothiazole with photochemically-produced hydroxyl radicals has been estimated as 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 0.64 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). 2-aminobenzothiazole is not expected to undergo hydrolysis in the environment due to the lack of functional groups to hydrolyze.

2-Aminobenzothiazole may be released into the environment in waste streams from its production and use as an azo dye intermediate and in photographic chemicals. The breakdown of the herbicide methabenzthiazuron may introduce 2-aminobenzothiazole into soil. If released to the atmosphere, 2-aminobenzothiazole is expected to exist solely as a vapor, based on an estimated vapor pressure of 1.1X10-4 mm Hg. Vapor-phase 2-aminobenzothiazole is expected to degrade quickly by reaction with photochemically produced hydroxyl radicals (estimated half-life of 0.64 hours). If released to the soil, 2-aminobenzothiazole is expected to adsorb to soil surfaces (estimated Koc of 1600). 2-Aminobenzothiazole is not expected to be volatile from moist or dry soil surfaces, based on an estimated Henry's Law constant of 1.3X10-10 atm-cu m/mol and an estimated vapor pressure of 1.1X10-4 mm Hg, respectively. If released to water, 2-aminobenzothiazole may adsorb to suspended soil and sediment based on an estimated Koc of 1600. 2-Aminobenzothiazole will be non-volatile from water surfaces, based on an estimated Henry's Law constant of 1.3X10-10 atm-cu m/mol. An estimated BCF of 19 suggests that bioconcentration of 2-aminobenzothiazole in aquatic organisms is low. Hydrolysis, biodegradation, and volatilization of 2-aminobenzothiazole are not expected to be environmentally important removal processes in aquatic systems. Occupational exposure to 2-aminobenzothiazole is expected to primarily occur through dermal contact in workplaces where it is used. (SRC)

Used in photographic chemicals and as an azo dye intermediate; [HSDB]

Photographic Processing [Category: Other]

IN PREPN OF AZO DYES

USED AS AN AZO DYE INTERMEDIATE; PHOTOGRAPHIC CHEMICALS