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シクラミン酸カルシウム

Calcium Cyclamate

HCID 8752
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
139-06-0
標準SMILES
O=S(=O)([O-])NC1CCCCC1.O=S(=O)([O-])NC1CCCCC1.[Ca+2]
InChIKey
UKLJMHXGZUJRTL-UHFFFAOYSA-L
分子式
C12H24CaN2O6S2
平均分子量
396.5 g/mol
単同位体質量
396.0701697

概要

See also: Sodium Cyclamate (related).

名称と識別子

優先名称
Calcium Cyclamate
IUPAC
calcium bis(N-cyclohexylsulfamate)
現地名
シクラミン酸カルシウム
英語名
Calcium bis(cyclohexylsulphamate)
分子式
C6H15CaNO3S
分子量
221.33

名称と別名

CALCIUM CYCLAMATE139-06-0Cyclamate calciumCyclanDietilCylanSucaryl calciumCalcium cyclohexanesulfamateKalziumzyklamateCyclamate, calcium saltCalcium cyclohexylsulphamateCalcium cyclohexane sulphamate
名称をさらに表示
シクロヘキシルスルファミン酸カルシウムビス(シクロヘキシルスルファミン酸)カルシウムシクラミン酸カルシウムシクランビス(N-シクロヘキシルスルファミン酸)カルシウムジエチルスカリルカルシウムビス(N-シクロヘキシルアミド硫酸)カルシウムカルシウムシクラマートサイクラミン酸カルシウムcacyclamatecalciumsucarylsucarylcalciumCalcium Cycalmate
X12LMJ1WYLCalcium cyclamate anhydrousCalcium cyclohexylsulfamate (1:2)Cyclohexanesulfamic acid, calcium salt (2:1)Sulfamic acid, cyclohexyl-, calcium salt (2:1)DTXSID9057892Cyclamate, CalciumINS NO.952(II)

データベース識別子

CAS
139-06-0

物性

構造計算による物性

極性表面積
155 Ų
水素結合供与体数
2
水素結合受容体数
8
回転可能結合数
2
重原子数
23
形式電荷
0
複雑度
187

実験および物理化学的性質

Chemical ClassesOther Uses -> Food Additives
CosmeticsMasking
TasteStrong, sweet taste
Color/FormCrystalline solid
Solubility · 4 件

Form: crystals; pleasant, very sweet taste; practically insol in alcohol, benzene, chloroform, ether; pH of 10% aq soln 5.5-7.5; Said to be more resistant to cooking temp than saccharin /Dihydrate/

ODORLESS; WHITE CRYSTALLINE POWDER; 1 G SOL IN 4 ML WATER; 1 G SOL IN 60 ML ETHANOL; 1 G SOL IN 1.5 ML PROPYLENE GLYCOL; LOSS ON DRYING @ 140 °C FOR 2 HR 9.0% MAX /DIHYDRATE/; IN DILUTE SOLN ABOUT 30 TIMES AS SWEET AS SUCROSE

SOL IN AQ SOLN OF SORBITOL; 25 G SOL IN 100 ML 25% ALCOHOL; 2.4 G SOL IN 100 ML 90% ETHYL ALCOHOL

Soluble in water. Insoluble in most organic solvents.

DecompositionWhen heated to decomposition it emits very toxic fumes of sulfoxides and nitroxides.
Refractive IndexINDEX OF REFRACTION: 1.507 (ALPHA), 1.518 (BETA), 1.545 (GAMMA) /DIHYDRATE/
Physical DescriptionSolid; [HSDB]
Other Experimental Properties · 2 件

NONHYGROSCOPIC, FREE-FLOWING; REACTS WITH TARTARIC ACID & TARTRATES, OXALATES, & SOME PHOSPHATES TO FORM INSOL CALCIUM SALTS

安全と法規制

安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 10.7% (6 of 56) of reports.

Warning

H315 (89.3%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 56 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 2 件

Chemical: Sulfamic acid, cyclohexyl-, calcium salt (2:1)

Sulfamic acid, cyclohexyl-, calcium salt (2:1): Does not have an individual approval but may be used under an appropriate group standard

Hazards SummarySee Sodium cyclamate.
Hazard Classes and CategoriesSkin Irrit. 2 (89.3%)

安全と保護具

Disposal Methods · 1 件

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

毒性情報

Milk ConcentrationsMILK LEVELS OF CYCLAMATE IN LACTATING DOGS & RATS ADMIN CA CYCLAMATE WERE HIGHER THAN BLOOD LEVELS & ACCOUNTED FOR 0.001% OF DOSE/ML.

化学と産業

薬理情報

Biological Half-Life...IV DOSE OF 14(C)-CYCLAMATE TO PREGNANT RAT...T/2 OF CYCLAMATE WAS ABOUT 7 HR. /CYCLAMATE/
Metabolism/Metabolites · 5 件

/CALCIUM/ CYCLAMATE LABELLED WITH (35)S OR (14)C IS EXCRETED BY MAN & LABORATORY ANIMALS ALMOST ENTIRELY UNCHANGED, IN URINE & FECES, ALTHOUGH TRACES OF...CYCLOHEXYLAMINE (0.7% DOSE) HAVE BEEN FOUND IN URINE OF HUMANS & DOGS DOSED ORALLY...

...BIOTRANSFORMATION IN RATS...IS BROUGHT ABOUT BY GUT MICROFLORA. ...GUT MICROFLORA IN MAN & IN ANIMALS ACQUIRE CAPACITY TO METABOLIZE CYCLAMATE INTO CYCLOHEXYLAMINE, WHEN CYCLAMATE IS ADMIN CHRONICALLY. /CYCLAMATE/

GUT MICRO-ORGANISMS, WHICH BECOME CYCLAMATE "CONVERTERS" ARE CLOSTRIDIA IN RATS, ENTEROBACTERIA IN RABBITS, & ENTEROCOCCI IN MAN. /CYCLAMATE/

...2 GROUPS OF WEANLING RATS WERE FED FOR 8 MO...WITH CHOW DIET OR...DIET CONTAINING 0.1% CA CYCLAMATE...THEN A SINGLE DOSE OF (14)C-CYCLAMATE BY STOMACH TUBE. ...7/11 CYCLAMATE-FED RATS CONVERTED CYCLAMATE INTO CYCLOHEXYLAMINE, TO...12-25% OF TOTAL (14)C IN URINE. 2 OF THE URINES CONTAINED TRACES OF DICYCLOHEXYLAMINE...

WHEN GUINEA PIGS, RABBITS, RATS, & HUMANS WERE PLACED ON A DIET CONTAINING CALCIUM CYCLAMATE THEY DEVELOPED THE ABILITY TO CONVERT ORALLY ADMIN CYCLAMATE INTO CYCLOHEXYLAMINE & THE METABOLITES OF THE LATTER.

MeSH Pharmacological ClassificationSubstances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)
Absorption, Distribution and Excretion · 5 件

...PREVIOUSLY THOUGHT TO BE METABOLICALLY STABLE. WHEN GIVEN ORALLY TO GUINEA PIGS, RABBITS, RATS, & HUMANS ON CYCLAMATE-FREE DIET IT IS EXCRETED LARGELY UNCHANGED. /CYCLAMATE/

...CYCLOHEXYLAMINE FORMED IN INTESTINE IS ALMOST COMPLETELY ABSORBED & EXCRETED IN URINE, IN COMPARISON TO CYCLAMATE, WHICH IS ABSORBED TO AN EXTENT OF ONLY 20-40%. /CYCLAMATE/

...(14)C-CYCLAMATE, GIVEN IV TO WOMEN UNDERGOING THERAPEUTIC ABORTION, BY ABDOMINAL HYSTERECTOMY DURING EARLY PREGNANCY, CROSSED PLACENTA & DISPERSED IN FETAL TISSUES, PARTICULARLY IN LIVER, SPLEEN, PANCREAS, & KIDNEYS. ...MATERNAL BLOOD LEVELS...FELL RAPIDLY...INDICATING VERY RAPID ELIMINATION... /CYCLAMATE/

関連反応

0 件
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化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
PubChem CID
8752
DTXSID
DTXSID9057892
ChEMBL
CHEMBL2104112
UNII
X12LMJ1WYL
EC Number
205-349-4
Nikkaji
J55.433B

White crystals or powder; nearly odorless; very sweet taste. Freely soluble in water(solutions are neutral to litmus); Sweetening power approximately 30 times that of sucrose. /Dihydrate/

物理化学的性質

Merck
13 · 13,1666
化粧品成分の機能
香料
EPAの化学物質情報
Calcium cyclamate(1:2) (139-06-0)
化学的性質 · 1 件

化学的特性White crystals or powder; nearly odor- less; very sweet taste. Freely soluble in water (solu- tions are neutral to litmus); almost insoluble in alco- hol, benzene, chloroform, and ether; p H (10% solu- tion) 5.5–7.5. Sweetening power approximately 30 times that of sucrose.

Human Toxicity Excerpts · 5 件

A WOMAN PATIENTS WHO TOOK LARGE AMT OF CA CYCLAMATE HAD A PHOTOSENSITIVE DERMATITIS & RENAL TUBULAR ACIDOSIS ASSOCIATED WITH HYPOPHOSPHATEMIA.

3 PATIENTS DESCRIBED DEVELOPED VESICAL CARCINOMA OF BLADDER AFTER PROLONGED PERIOD OF INGESTION OF UNUSUALLY HIGH AMT OF CYCLAMATE SWEETNER, SEVERITY APPEARED IN PROPORTION TO DOSE INGESTED.

An epidemiologic study designed to elucidate the possible roles of the artificial sweeteners saccharin and cyclamate in human urinary bladder cancer was completed. The previous intake of each of these substances among 519 patients with histopathologically confirmed bladder cancer and an equal number of matching controls in metropolitan Baltimore (USA) did not differ significantly in frequency, quantity or duration. These normal findings persisted after simultaneous adjustment for the effects of smoking, occupation, age, diabetes mellitus and a number of other potentially confounding factors. They are substantiated by the failure of the relative risk of bladder cancer to increase with increasing exposure to artificial sweeteners. Neither saccharin nor cyclamate is likely to be carcinogenic in man, at least at the moderate dietary ingestion levels reported by the patient sample.

IN VIVO, CYCLAMATE IS CONVERTED INTO CYCLOHEXYLAMINE WHICH PER SE OR AFTER BIOTRANSFORMATION MAY PROVIDE AN ULTIMATE CARCINOGEN. /CYCLAMATE/

For more Human Toxicity Excerpts (Complete) data for CALCIUM CYCLAMATE (6 total), please visit the HSDB record page.

Non-Human Toxicity Excerpts · 5 件

IN SMALL DOSES /CALCIUM/ CYCLAMATE IS NON-TOXIC, BUT HIGH DOSES (5% OF DIET) FED TO RATS CAUSE DIARRHEA & RETARD GROWTH.

GROUPS OF 30 MALE & 30 FEMALE...HAMSTERS RECEIVED CALCIUM CYCLAMATE... CONTAINING A TRACE OF CYCLOHEXYLAMINE AT LEVELS OF 0, 0.156, 0.312, 0.625 & 1.25% IN DRINKING WATER FOR...NATURAL LIFESPAN. ...NO APPARENT DIFFERENCES IN TUMOR INCIDENCE...NOTED BETWEEN TREATED & CONTROL ANIMALS. ...NO BLADDER TUMORS...NOTED IN ANY GROUP.

MALE...RATS (20-28/GROUP) RECEIVED A NORMAL (20%) OR LOW (10%) PROTEIN SEMISYNTHETIC DIET CONTAINING 0, 1 OR 2% CA CYCLAMATE...FOR 75 WK. A TRANSITIONAL-CELL PAPILLOMA OCCURRED IN URINARY BLADDER OF 1/11 ANIMALS EXAMINED (20% PROTEIN, 2% CA CYCLAMATE DIET); KIDNEYS & URINARY BLADDER...CONTAINED STONES & CALCIUM DEPOSITS.

...0.4, 2 OR 10% CA CYCLAMATE...WAS GIVEN WITH NORMAL CHOW DIET TO 14 MALE & 14 FEMALE...RATS FOR 101 WK. A CONTROL GROUP CONSISTED OF 28 ANIMALS. AFTER 88 WK, 2 TRANSITIONAL-CELL PAPILLOMAS OF URINARY BLADDER (1/6 IN 0.4% GROUP & 1/4 IN 10% GROUP) WERE NOTED; 3 TRANSITIONAL-CELL CARCINOMAS OF URINARY BLADDER WERE...FOUND (2/6 IN 0.4% GROUP & 1/4 IN 10% GROUP). SOME ANIMALS IN THIS STUDY HAD BLADDER PARASITES.

For more Non-Human Toxicity Excerpts (Complete) data for CALCIUM CYCLAMATE (21 total), please visit the HSDB record page.

安全データ

tsca
TSCA listed
rtecs
GV7100000
risk_code
36/37/38
hazard_code
Xn
safety_code
26-36
有毒物質データの
139-06-0(Hazardous Substances Data)

MAX DAILY EXCRETION OF CYCLOHEXYLAMINE...RANGED FROM 0.1 TO 0.9% OF DAILY CYCLAMATE INTAKE (5 G); URINARY OUTPUT OF CYCLOHEXYLAMINE WAS ERRATIC & CONTINUED FOR 3-4 DAYS AFTER ADMIN HAD CEASED. /CYCLAMATE/

For more Absorption, Distribution and Excretion (Complete) data for CALCIUM CYCLAMATE (6 total), please visit the HSDB record page.

用途と製造

Uses · 3 件

Used as a non-caloric sweetener in foods; [HSDB]

Cyclamates: Banned by the FDA for use in foods in 1970 (also banned in many other countries); [HSDB]

FORMERLY AS A NONCALORIC SWEETENER IN BEVERAGES & FOOD PRODUCTS

U.S. Production · 2 件

(1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS

(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS

Consumption PatternsSALE OF BEVERAGES CONTAINING CYCLAMATES WAS PROHIBITED BY US FOOD & DRUG ADMINISTRATION ON JANUARY 1, 1970, AND SALE OF OTHER FOOD PRODUCTS CONTAINING CYCLAMATES WAS PROHIBITED ON SEPTEMBER 1, 1970 (1970)
Methods of Manufacturing · 2 件

Cummins, Johnson; McQuaid, US patents 2,799,700; 2,804,477 (both 1957 to Du Pont); Freifelder, US patent 3,082,247 (1963 to Abbott); Birsten, Rosin, US patents 3,361,798; 3,366,670 (both 1968 to Baldwin-Montrose).

...BY NEUTRALIZING CYCLAMIC ACID WITH...CALCIUM HYDROXIDE...OR BY SULFONATION OF CYCLOHEXYLAMINE WITH...CALCIUM SULFAMATE.

Formulations/Preparations · 4 件

...SOLD UNDER TRADEMARK, SUCH AS SUCARYL CALCIUM OF ABBOTT LABORATORIES & CYLAN CALCIUM CYCLAMATE OF DUPONT.

CYCLAN; CYLAN; DIETIL...IN THE US, CALCIUM CYCLAMATE WAS AVAILABLE COMMERCIALLY IN 1970 AS A US NATIONAL FORMULARY (NF) GRADE CRYSTALLINE POWDER CONTAINING 98-101% ACTIVE INGREDIENT ON AN ANHYDROUS BASIS, 6-9% WATER, A MAXIMUM OF 30 MG/KG SELENIUM, 25 MG/KG CYCLOHEXYLAMINE, 10 MG/KG HEAVY METALS & 3 MG/KG ARSENIC. ...AQ SOLN CONTAINING ABOUT 6% CALCIUM CYCLAMATE COMBINED WITH ABOUT 0.6% CALCIUM SACCHARIN, &...TABLETS CONTAINING ABOUT 50 MG CALCIUM CYCLAMATE COMBINED WITH ABOUT 5 MG CALCIUM SACCHARIN.

Grades: NF, FCC /Dihydrate/

PURITY: 98% MINIMUM /DIHYDRATE/

Use Classification · 2 件

Food Additives -> SWEETENER -> JECFA Functional Classes

Cosmetics -> Masking

General Manufacturing Information · 4 件

Sulfamic acid, N-cyclohexyl-, calcium salt (2:1): INACTIVE

CYCLAMATES ARE CURRENTLY BANNED AS FOOD ADDITIVES IN MANY COUNTRIES (USA, UK, CANADA, SWEDEN, FINLAND, ETC).

NON-CALORIC SWEETENING AGENT USED ALONE OR IN COMBINATION WITH SACCHARIN ... TEN PARTS CYCLAMATE TO ONE PART SACCHARIN IS A COMMON COMBINATION ... SOME NON-NUTRITIVE SOFT DRINKS CONTAIN 0.125% CYCLAMATE. /CYCLAMATE SODIUM OR CALCIUM/

Cyclamate sweeteners, once available in the United States but now banned ... are still available in Canada.

応用分野

使用Nonnutritive sweetener.

上流・下流製品情報

上流原料

アミド硫酸 アンモニウムN-シクロヘキシルスルファミン酸水酸化カルシウムシクロヘキシルアミン

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