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トリス酢酸アルミニウム
酢酸アルミニウム · トリス(酢酸)アルミニウム · トリス酢酸アルミニウム · ドメボロ · 三酢酸アルミニウム · ブロー液 · Burow液 · Burow氏液
識別子と物理属性
| CAS No. | 139-12-8 |
|---|---|
| 分子式 | C6H9AlO6 |
| 平均分子量 | 204.11 g/mol |
| 単同位体質量 | 204.02145164 g/mol |
| SMILES | CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].[Al+3] |
| InChIKey | WCOATMADISNSBV-UHFFFAOYSA-K |
| PubChem CID | 8757 |
| ChEMBL | CHEMBL1201015 |
| EC No. | 205-354-1 |
| DTXSID | DTXSID30890496 |
| 現地名 | トリス酢酸アルミニウム |
化学・物理的性質
| 極性表面積 | 120 |
|---|---|
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 6 |
| 回転可能結合数 | 0 |
| 重原子数 | 13 |
| 形式電荷 | 0 |
| 複雑度 | 25.5 |
| 物質分類 | Metals -> Organic Acids, Metal Salts |
| 化粧品 | Antimicrobial |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Physical Description | Neutral form: White solid, soluble in water[Hawley] |
| 融点 | decomposes with moisture [CRC10] |
| 密度 | 1.002 g/cm3 |
| 溶解度 | soluble in H2Oslightly soluble in acetone可溶性H2O [HAW93] |
| 色 | white hygroscopic solid |
| 化粧品成分の機能 | 収斂性抗菌剤 |
| LogP（分配係数） | -0.285 (est) |
| EPAの化学物質情報 | Acetic acid, aluminum salt (139-12-8) |
化学的特性
white powder(s); preparation: by heating aluminum or AlCl3 with an acetic acid solution containing acetic anhydride; uses: as an antiseptic, an astringent, and in antiperspirant applications; there is a hydroxyaluminum diacetate, CAS RN 142-03-0 [CIC73] [HAW93] [ALD94]
安全性と法規制
| GHS 分類 | This chemical does not meet GHS hazard criteria for 40.2% (70 of 174) of reports.WarningH315 (59.8%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 174 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | Chemical: Acetic acid, aluminium salt |
| 有害性の概要 | There are three aluminum acetatesAl(CO2CH3)3 has CAS 139-12-8[Ullmann] See Aluminum. |
| Hazard Classes and Categories | Skin Irrit. 2 (59.8%) |
| Minimum Risk Level | Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) |
| 健康影響 | Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
| 暴露経路 | Oral (L739)inhalation (L739) |
| 毒性の概要 | The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) |
| Signs and Symptoms | Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
| Carcinogen Classification | Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). |
| TSCA 収載状態 | TSCA listed |
用途
解説
化学式 Al(CH3CO2)3 。アルミニウムエトキシドと酢酸とを反応させてつくる。正塩と塩基性塩とがある。白色，無定形の粉末で水に溶けやすく，防水布，医薬，捺染，死体の防腐・保存剤などに広く使われる。
説明
Aluminum acetate is a chemical compound and is a salt which can be produced by the reaction of aluminum hydroxide and acetic acid. The compound formula for Aluminum Acetate is Al(CH3COO)3.
使用
Astringent.
製法・合成法
調製方法
Ammonium acetate is produced by the neutralization of acetic acid with ammonium carbonate or by saturating glacial acetic acid with dry ammonia gas. Obtaining crystalline ammonium acetate is difficult on account of its aqueous solution giving off ammonia when evaporated.