5-ビニル-2-メチルピリジン

(Non-Specific -- Combustible Liquid, n.o.s.) Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. Move container from fire area if you can do so without risk. Spray cooling water on containers that are exposed to flames until well after fire is out. For massive fire in cargo area, use unmanned hose holder or monitor nozzles; if this is impossible, withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire.

(Non-Specific -- Combustible Liquid, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Shut off ignition sources; no flares, smoking, or flames in hazard area. Stop leak if you can do so without risk. Use water spray to reduce vapors. Absorb spills with sand or noncombustible absorbent material. For large spills dike far ahead. (EPA, 1998)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

0.17 [mg/m3]

1.9 [mg/m3]

6.6 [mg/m3]

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

Vapor concentration: 250 ppm or less; a chemical cartridge respirator with a full facepiece and an organic vapor cartridge(s), a gas mask with a chin-style or a front- or back-mounted organic vapor canister, any supplied-air respirator with a full facepiece, helmet, or hood, or any self-contained breathing apparatus with a full facepiece. 3600 ppm or less: a Type C supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure mode or with a full facepiece, helmet, or hood operated in continuous-flow mode. Greater than 3600 ppm or entry and escape from unknown concentrations: self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode. /Pyridine/

Depending on the extent of possible contact, workers should be provided with personal protective equipment. A charcoal gas mask canister respirator has been found to be effective against a 2% pyridine concentration at 30 l/min for 1 hr. Rubber and plastic gloves should not be relied upon to prevent skin contact because pyridine and many of its derivatives penetrate these materials ... . /Pyridine, homologs, and derivatives/

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that 2-methyl-5-vinylpyridine is expected to have moderate mobility in soil(SRC). 2-Methyl-5-vinylpyridine has a pKa of 5.67(5), which indicates that this compound will partially exist in the protonated form in moist acidic soils, and cations adsorb more strongly to soils than neutral molecules. Therefore, the mobility of 2-methyl-5-vinylpyridine is expected to be much lower in acidic soils than in neutral or alkaline soil(SRC). Volatilization of the neutral species of 2-methyl-5-vinylpyridine from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(3). However, the protonated form will not volatilize(SRC). The potential for volatilization of 2-methyl-5-vinylpyridine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.18 mm Hg(4). Biodegradation data were not located for 2-methyl-5-vinylpyridine; however a structurally-similar compound, 2-methyl-5-ethylpyridine was not biodegraded during a 28-day chemostat experiment(6) indicating that this compound may also be resistant to biodegradation in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 170(SRC), determined from a structure estimation method(2), indicates that 2-methyl-5-vinylpyridine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 9 and 71 days, respectively(SRC). The pKa of 2-methyl-5-vinylpyridine is 5.67(8), indicating this compound will partially exist in the ionized form in acidic waters and cations do not volatilize(SRC). According to a classification scheme(5), an estimated BCF of 11(SRC), from an estimated log Kow of 2.25(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not located for 2-methyl-5-vinylpyridine; however a structurally-similar compound, 2-methyl-5-ethylpyridine, was not biodegraded during a 28-day chemostat experiment(9) indicating that this compound may also be resistant to biodegradation in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-methyl-5-vinylpyridine, which has a vapor pressure of 1.18 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase 2-methyl-5-vinylpyridine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 hours(SRC), calculated from its rate constant of 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Vapor-phase 2-methyl-5-vinylpyridine is also degraded in the atmosphere by reaction with ozone(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 2.1X10-17 cu cm/molecule-sec at 25 °C(SRC), determined using a structure estimation method(3).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2-methyl-5-vinylpyridine can be estimated to be 170(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-methyl-5-vinylpyridine is expected to have moderate mobility in soil. The pKa of 2-methyl-5-vinylpyridine is 5.67(3), which indicates that this compound will partially exist in the protonated form under acidic conditions. Cations adsorb more strongly to soil surfaces than neutral molecules thus adsorption of 2-methyl-5-vinylpyridine is expected to be greater in acidic soils(SRC).

AEROBIC: No data were located for 2-methyl-5-vinylpyridine although a chemostat experiment for a structurally-similar compound suggests that 2-methyl-5-vinylpyridine may be resistant to biodegradation. 2-Methyl-5-ethylpyridine was not biodegraded over a 28-day chemostate experiment using groundwater; 2-methyl-5-ethylpyridine was present initially at 5276 ug/l with a dilution rate of 0.067 per day)(1). The effluent concentration was 5075 ug/l(1). biodegradation, as measured by BOD, were reported for 2-vinyl- and 4-vinylpyridine (initially present at 100 mg/l) in the 4-week Japanese MITI test(1).

An estimated BCF of 11 was calculated for 2-methyl-5-vinylpyridine(SRC), using an estimated log Kow of 2.3(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for 2-methyl-5-vinylpyridine is estimated as 4.4X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 2-methyl-5-vinylpyridine is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 9 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 71 days(SRC). 2-Methyl-5-vinylpyridine's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). However, 2-methyl-5-vinylpyridine is a weak base with a pKa of 5.67(3), which indicates this compound will partially exist in the protonated form in acidic conditions; cations do not volatilize from either moist soil or water surfaces. The potential for volatilization of 2-methyl-5-vinylpyridine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.18 mm Hg(4).

2-Methyl-5-vinylpyridine was admin at 157 mg/kg orally daily to rats throughout pregnancy. The structure and composition of the liver and the structure and growth pattern of the skin were disrupted in the offspring of the treated rats, indicating placental permeability to these pyridine derivatives or their toxic by-products.

Chronic intoxication changes in rats caused by 2-methyl-5-vinylpyridine were related to the histohematic barrier. These included changes in structural elements of the blood-brain barrier of the brain vessels, endothelium and epithelium of the vascular plexus, and Kupffer cells, in the content and distribution of nucleotides, proteins, and enzymes, in organ function, etc.

Daily admin of 0.1 or 1 mg 2-methyl-5-vinylpyridine/kg for 30-180 days injured neurons of the sensory and motor sections of the spinal cord of rats. Chromatolysis and vacuolization of neurons occurred in the horns of the spinal cord. The number of neurons with low levels of succinate dehydrogenase and glutamate dehydrogenase activity was incr.

Daily oral admin of 300 mg 2-methyl-5-vinylpyridine for 10 days decr the number of highly active cells in the /hypothalamic-hypophyseal neurosecretory system (HHNS)/ of rats, decr the number of less active cells, decr the diameter of cell nuclei, and induced the accumulation of neurosecretion in the nerve fibers and neurohypophysis. Initially the formation of neurosecretion and its translocation into the blood stream was disturbed, and later the formation was disturbed in the hypothalamus. The overall function of the /hypothalamic-hypophyseal neurosecretory system/ was inhibited and the secretion of neurohormones into the blood stream was disturbed.

For more Non-Human Toxicity Excerpts (Complete) data for PYRIDINE, 2-METHYL-5-VINYL (6 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of 2-methyl-5-vinylpyridine with photochemically-produced hydroxyl radicals has been estimated as 2.7X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 14 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of 2-methyl-5-vinylpyridine with ozone has been estimated as 2.1X10-17 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 13 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). 2-Methyl-5-vinylpyridine is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3). Data are not available to assess this compound's potential for direct photolysis. A pKa of 5.67(4) indicates 2-methyl-5-vinylpyridine will partially exist in the protonated form in acidic waters and soils.

2-Methyl-5-vinylpyridine's production and use as a monomer for resins, oil additive, ore flotation agent and dye acceptor may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 1.18 mm Hg at 25 °C indicates 2-methyl-5-vinylpyridine will exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-methyl-5-vinylpyridine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone; the half-lives for these reactions in air are estimated to be 14 and 13 hours, respectively. If released to soil, 2-methyl-5-vinylpyridine is expected to have moderate mobility based upon an estimated Koc of 170. 2-Methyl-5-vinylpyridine has a pKa of 5.67, which indicates that this compound will partially exist in the protonated form in moist acidic soils; cations adsorb more strongly to soils than neutral molecules. Therefore, the mobility of 2-methyl-5-vinylpyridine is expected to be much lower in acidic soils than in neutral or alkaline soils. Volatilization from moist soil surfaces is expected to be an important fate process based upon an estimated Henry's Law constant of 4.4X10-6 atm-cu m/mole. However, in moist acidic soils, where the protonated form is the dominant species, volatilization will not be important because cations do not volatilize. 2-Methyl-5-vinylpyridine may volatilize from dry soil surfaces based upon its vapor pressure. Biodegradation data were not located for 2-methyl-5-vinylpyridine; however a structurally-similar compound, 2-methyl-5-ethylpyridine, was not biodegraded during a 28-day chemostat experiment indicating that this compound may also be resistant to biodegradation in the environment. Volatilization of the neutral species from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 9 and 71 days, respectively. In acidic waters where the protonated form is the dominant species, volatilization will not be an important fate process since cations do not volatilize. An estimated BCF of 11 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to 2-methyl-5-vinylpyridine may occur through inhalation and dermal contact with this compound at workplaces where 2-methyl-5-vinylpyridine is produced or used. (SRC)

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Pyridine, 2-methyl-5-vinyl is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 lbs.