| GHS 分類 | DangerH225: Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (2 of 4896) of reports.H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids] |
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| 規制情報 | Chemical: 2-Propenoic acid, ethyl esterHazard Traits - CarcinogenicityHepatotoxicity and Digestive System ToxicityNeurotoxicityRespiratory ToxicityCommission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)2-Propenoic acid, ethyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, ethyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 11-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/154312-Propenoic acid, ethyl ester: HSNO Approval: HSR001042 Approved with controls |
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| その他の安全情報 | IMAP assessments - 2-Propenoic acid, ethyl ester: Human health tier II assessment |
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| 輸送ラベル（DOT） | Flammable Liquid |
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| 火災危険 | Special Hazards of Combustion Products: Toxic and irritating vapors generated when heated.· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.Highly flammable. Vapour/air mixtures are explosive. |
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| 火災の可能性 | Flammable liquid. A very dangerous fire hazard when exposed to heat or flame. |
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| 健康有害性 | May cause irritation and burns of eyes and skin. Exposure to excessive vapor concentrations can also cause drowsiness accompanied by nausea, headache, or extreme irritation of the respiratory tract. (USCG, 1999)· May cause toxic effects if inhaled or absorbed through skin. |
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| 有害性の概要 | Exposure to ethyl acrylate is primarily occupational. Acute (short-term) exposure of workers to ethyl acrylate vapors has been reported to cause drowsiness, lethargy, headache, nausea, convulsions, and respiratory and gastrointestinal irritation. Noncancerous lesions and inflammation of the nasal mucosa and depressed body weight gain have been observed in rats and mice exposed by inhalation for a chronic (long-term) duration. Human studies on occupational exposure to ethyl acrylate/methyl methacrylate have suggested a relationship between exposure to the chemical(s) and colorectal cancer, but the evidence is conflicting and inconclusive. In a study by the National Toxicology Program (NTP), increased incidences of squamous cell papillomas and carcinomas of the forestomach were observed in rats and mice exposed via gavage (experimentally placing the chemical in the stomach). However, the NTP recently determined that these data were not relevant to human carcinogenicity and removed ethyl acrylate from its list of carcinogens. EPA has classified ethyl acrylate as a Group B2, probable human carcinogen, but has not developed a potency estimate to quantify risk by inhalation.Liquid causes first degree burns on short exposure. [CHRIS] Pulmonary edema may result from inhalation of high concentrations. [NJ-HSFS] A lachrymatorCauses damage to the liver, kidneys, and lungs in high-dose animal experiments[HSDB] Danger of skin sensitization[MAK] Ethyl acrylate, stabilized (UN1917) has warning of explosive polymerization[ERG 2016] |
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| 輸送番号・ガイド（DOT） | 1917 129P1917 129P(inhibited) |
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| FDA 要件 | Ethyl acrylate is a food additive permitted for direct addition to food for human consumption in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and b) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.Homopolymers and copolymers of ethyl acrylate are an indirect food additive for use only as a component of adhesives. |
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| 反応性グループ | Acrylates and Acrylic Acids |
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| EC 分類 | Symbol: F, XnR: 11-20/21/22-36/37/38-43S: (2)-9-16-33-36/37Note: D |
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| UN 分類 | UN Hazard Class: 3UN Pack Group: II |
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| 消火 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)polymerization hazard]:Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
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| 応急処置措置 | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention . |
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| 漏出応急措置 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
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| 応急処置 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.General First Aid:(General first aid procedures) |
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| 安全保管 | Fireproof. Cool. Keep in the dark. Store only if stabilized. |
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| Firefighting Hazards | Vapor is heavier than air and may travel a considerable distance to a source of ignition and flash back. Liquid floats on water and may travel to a source of ignition and spread fire. /Ethyl acrylate, inhibited/ |
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| 暴露管理・個人防護 | · Wear positive pressure self-contained breathing apparatus (SCBA).315.0 [ppm]2.0 [ppm] |
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| 消火手順 | Use water spray to keep fire-exposed containers cool. Use fine spray or fog to control fire by preventing its spread and absorbing some of its heat. Solid streams of water may be ineffective or may cause frothing. Use water spray, dry chemical, foam, or carbon dioxide. Fight fire from protected location or maximum possible distance. /Ethyl acrylate, inhibited/If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid stream of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical or carbon dioxide. /Ethyl acrylate, stabilized/Wear full protective clothing and positive pressure self contained breathing apparatus.Evacuation: If fire becomes uncontrollable or container is exposed to direct flame, consider evacuation of one-half (1/2) mile radius. /Ethyl acrylate, stabilized/ |
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| 保管条件 | Store in away from heat, oxidizers, and sunlight. Outside or detached storage is preferred. Separate from any oxidizers, peroxides, or other initiators. /Ethyl acrylate, inhibited/PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/The effectiveness of phenolic inhibitors is dependent on the presence of oxygen and the monomers must be stored under air rather than an inert atmosphere. Temp must be kept low to minimize formation of peroxides and other products. ... The acrylic esters may be stored in mild or stainless steel, or aluminum. /Acrylic acid & derivatives/ |
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| 清掃方法 | SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in safe place (such a fume hood). Allow sufficient time for evaporating vapors to completely clear hood ductwork. Burn paper in a suitable location away from combustible material. Large quantities can be collected and atomized in a suitable combustion chamber. Ethyl acrylate should not be allowed to enter a confined space, such as sewer, because of the possibility of an explosion.PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/ |
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| 非火災時の漏出対応 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)polymerization hazard]: |
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| 処分方法 | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U113, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.A good candidate for liquid injection incineration at a temperature range of 650 to 1,600 °C and a residence time of 0.1 to 2 seconds. Also, a good candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. Also, a good candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.Ethyl Acrylate is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration. /From table/PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/For more Disposal Methods (Complete) data for Ethyl acrylate (10 total), please visit the HSDB record page. |
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| Treatment | For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport. Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal. (A569) |
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| Cancer Sites | [in animals: tumors of the forestomach] |
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| 相互作用 | Pretreatment of rats with triorthotolyl phosphate potentiated the lethal action of inhaled methyl and ethyl acrylate. Carboxylesterases are important in detoxification of methyl and ethyl acrylate and the exposure to inhibitors of carboxylesterase may potentiate adverse effects of acrylate esters. |
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| 標的器官 | Eyes, skin, respiratory system |
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| 健康影響 | Thickened forestomach mucosa, forestomach inflammation and lesions, and abdominal adhesionsswelling of renal tubules and the liver, minor lesions on the liver and lung, and increased kidney weight may result from poisoning (L1242). |
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| 生態毒性値 | LC50Species: Pimephales promelas (Fathead minnow, age 32 days, length 18.7 mm, weight 0.095 g)Conditions: freshwater, flow through, 25.3 °C, pH 7.5, hardness 46.9 mg/L CaCO3, alkalinity 39.7 mg/L CaCO3, dissolved oxygen 6.8 mg/LConcentration: 2500 ug/L for 96 hr (95% confidence interval: 2310-2700 ug/L) /99% purity/Bacteria: Pseudomonas putida: inhibition of cell multiplication starts at 270 mg/LAlgae: Microcystis aeruginosa: inhibition of cell multiplication starts at 14 mg/L |
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| 環境中動態 | TERRESTRIAL FATE: Based on a classification scheme(1), a Koc range of 4-85(2) indicates that ethyl acrylate is expected to have very high to high mobility in soil(SRC). Volatilization of ethyl acrylate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.4X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 38.6 mm Hg(3), and water solubility, 1.5X10+4 mg/L(4). Ethyl acrylate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Utilizing the Japanese MITI test, 52% of the Theoretical BOD was reached in 2 weeks(5) indicating that biodegradation is an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), a Koc range of 4-85(2) indicates that ethyl acrylate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.4X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 38.6 mm Hg(4), and water solubility, 1.5X+4 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow of 1.32(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A base-catalyzed second-order hydrolysis rate constant of 7.8X10-2 L/mol-sec was determined at approximately 25 °C for ethyl acrylate(9)this corresponds to half-lives of 3 years, 103 days, and 2.5 hours at pH values of 7, 8 and 11, respectively(SRC). Ethyl acrylate readily biodegrades in screening tests using sewage seed both in fresh and salt water(10)it reached 52% of its theoretical BOD in 2 weeks using an activated sludge inoculum(11).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethyl acrylate, which has a vapor pressure of 38.6 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl acrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 1.5 days(SRC), calculated from its rate constant of 1.6X10-11 cu cm/molecule-sec at 25 °C(3). A major removal process of ethyl acrylate from the atmosphere is reaction with ozonemajor transformation products include glyoxylic acid, ethyl glyoxylate, ethyl formate and epoxides(4). The rate constant for the reaction of ethyl acrylate with ozone is 5.7X10-18 cu cm/molc-sec, corresponding to a half-life of 2 days(5). Ethyl acrylate does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(5). |
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| 食品調査値 | FOUND IN THE FRUIT OF ANANAS SATIVUS L.Ethyl acrylate has been reported to be a volatile component of pineapple concentrate(1). Ethyl acrylate is a volatile component of Beaufort cheese, a Gruyere type cheese manufactured in a limited area of the French Alps(2). |
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| 有害作用 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
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| 暴露経路 | The substance can be absorbed into the body by inhalation, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contactInhalation (T21)oral (T21)dermal (T21)eye contact (T21). |
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| 毒性の概要 | Ethyl acrylate causes gastric lesions depending upon upon the rate of chemical delivery to stomach tissue as a result of interaction of the parent molecule or metabolites (other than hydrolysis products), with subcellular sites in stomach tissue (A2451). |
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| 生態毒性抜粋 | /AQUATIC SPECIES/ ... Toxicity tests were conducted using freshwater and marine fish, invertebrates, and algae. Acrylic acid effect concentrations for fish and invertebrates ranged from 27 to 236 mg/l. Effect concentrations (LC50 or EC50) for fish and invertebrates using methyl acrylate, ethyl acrylate, and butyl acrylate ranged from 1.1 to 8.2 mg/lL The chronic MATC for acrylic acid with Daphnia magna was 27 mg/L based on length and young produced per adult reproduction day and for ethyl acrylate was 0.29 mg/L based on both the reproductive and growth endpoints... Overall these studies show that acrylic acid and the acrylic esters studied can rapidly biodegrade, have a low potential for persistence or bioaccumulation in the environment, and have low to moderate toxicity. |
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| RCRA 要件 | U113As stipulated in 40 CFR 261.33, when ethyl acrylate, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5). |
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| TSCA 要件 | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Ethyl acrylate is included on this list. Effective date 4/13/89Sunset date: 6/30/98. |
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| FIFRA 要件 | Residues resulting from the use of the following substances, that meet the definition of a polymer and the criteria specified for defining a low-risk polymer in 40 CFR 723.250, as an inert ingredient in a pesticide chemical formulation, including antimicrobial pesticide chemical formulations, are exempted from the requirement of a tolerance under FFDCA section 408, if such use is in accordance with good agricultural or manufacturing practices. Ethyl acrylate is included on this list. |
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| 大気基準 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethyl acrylate is produced, as an intermediate or a final product, by process units covered under this subpart. |
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| CERCLA 報告数量 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b). |
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| 州飲料水ガイドライン | (FL) FLORIDA 5,000 ug/l |
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| 注意喚起語 | 危険 |
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| 危険有害性情報 | コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード H225 |
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