| GHS 分類 | WarningH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P272, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (1 of 3522) of reports.H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids] |
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| 規制情報 | Chemical: 2-Propenoic acid, butyl ester2-Propenoic acid, butyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, butyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 28-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/157792-Propenoic acid, butyl ester: HSNO Approval: HSR001100 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| その他の安全情報 | IMAP assessments - 2-Propenoic acid, butyl ester: Human health tier II assessment |
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| 輸送ラベル（DOT） | Flammable Liquid |
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| 火災危険 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)polymerization hazard]:Flammable. Above 36 °C explosive vapour/air mixtures may be formed. |
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| 火災の可能性 | A flammable liquid when exposed to heat or flame.Combustible liquid. Thermally unstable. |
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| 健康有害性 | Vapor is irritating when breathed at high concentrations. Contact with liquid causes irritation of skin and burning of eyes. (USCG, 1999) |
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| 有害性の概要 | Can cause skin sensitizationCan cause pulmonary edema after heavy inhalation exposure[ICSC] If left on clothing, can cause reddening of skin[CHRIS] Butyl acrylate is a skin irritant. [Quick CPC] A lachrymator[HSDB] A dermal sensitizer[ACGIH] Butyl acrylates, stabilized (UN2348) has warning of explosive polymerization[ERG 2016] |
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| 輸送番号・ガイド（DOT） | 2348 129P |
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| FDA 要件 | Homopolymers and copolymers of butyl acrylate are an indirect food additive for use only as a component of adhesives. |
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| 反応性グループ | Acrylates and Acrylic Acids |
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| EC 分類 | Symbol: XiR: 10-36/37/38-43S: (2)-9Note: D |
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| UN 分類 | UN Hazard Class: 3UN Pack Group: III |
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| 消火 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)polymerization hazard]:Use powder, AFFF, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
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| 応急処置措置 | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . |
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| 応急処置 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.(General first aid procedures) |
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| 安全保管 | Fireproof. Cool. Keep in the dark. Separated from strong oxidants. Store only if stabilized. |
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| 暴露管理・個人防護 | 2.0 [ppm] |
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| 消火手順 | Use water spray to keep fire exposed containers cool. Solid streams of water may be ineffective or may cause frothing. Use water spray, dry chemical, foam, or carbon dioxide. Fight fire from protected location or maximum possible distance.If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid stream of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical or carbon dioxide. /Butyl acrylates, stabilized/Use dry chemical, carbon dioxide, or foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position.Wear full protective clothing and positive pressure self-contained breathing apparatus. |
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| 保管条件 | Do not store unless stabilized. Before entering a confined space where butyl acrylate may be present, check to make sure that an explosive concentration does not exist. Store in tightly closed containers in a cool, well ventilated, fireproof area. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard.Separate from any oxidizing materials, peroxides, or other initiators. Store in a cool, dry, well-ventilated location. Outside or detached storage is preferred.The effectiveness of phenolic inhibitors is dependent on the presence of oxygen and the monomers must be stored under air rather than an inert atmosphere. Temp must be kept low to minimize formation of peroxides and other products ... The acrylic esters may be stored in mild or stainless steel, or aluminum. /Acrylic acid and derivatives/ |
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| 清掃方法 | SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Spill Handling: Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Cover liquids with dry lime or soda ash or absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. |
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| 非火災時の漏出対応 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)polymerization hazard]: |
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| 処分方法 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations.Disposal method suggested: Incineration /SRP: with emissions Controls/The following wastewater treatment technologies have been investigated for butyl acrylate: Activated carbon. |
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| 漏出処分 | Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Remove all ignition sources. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
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| Preventive Measures | SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.SRP: Contaminated protective clothing should be segregated in a manner that results in no direct personal contact by personnel who handle, dispose of, or clean the clothing. Quality assurance procedures to confirm the efficacy of the cleaning procedures should be implemented prior to the decontaminated protective clothing being returned for reuse by the workers. Contaminated clothing (including shoes/socks) should not be taken home at end of shift, but should remain at employee's place of work for cleaning.Awareness of the dangers and of good engineering design are essential to safety. Employees should be instructed about the necessity of cleansing the skin if it is contaminated by materials which are irritants or skin-absorbed. With careful design, however, and complete enclosure of those processes where toxic chemicals or intermediates occur, dangerous exposures can be avoided. /Acrylic acid & derivatives/If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock down vapors. /Butyl acrylates, stabilized/For more Preventive Measures (Complete) data for n-Butyl acrylate (7 total), please visit the HSDB record page. |
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| 標的器官 | Eyes, skin, respiratory system |
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| 生態毒性値 | LC50Species: /Agelaius phoeniceus/ (Red-wing blackbird)Concentration: >103 mg/kg bw for 18 hr /Conditions of bioassay not specified in source examined/Species: Daphnia magna (Water flea, age < or =24 hr)Conditions: freshwater, static, 20-22 °C, pH 7.6-7.7Concentration: 230 mg/L for 24 hr /formulation/Species: Cyprinodon variegatus (Sheepshead minnow)Conditions: flow-through, temperature 22.5-23.5 °C, pH 7.8-7.9, salinity 20-22% (parts per thousand), dissolved oxygen 6.0-7.8 mg/LConcentration: 2.1 mg/L for 96 hrSpecies: Oncorhynchus mykiss (Rainbow trout)Conditions: flow through, hardness 43-44 mg/L (as CaCO3), alkalinity 56-57 mg/L (as CaCO3), pH 7.5-7.9, conductivity 102-115 uMhos/cm, total organic carbon <1 mg/L, suspended solids 0.4 mg/LConcentration: 5.2 mg/L for 96 hrFor more Ecotoxicity Values (Complete) data for n-Butyl acrylate (10 total), please visit the HSDB record page. |
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| 環境中動態 | TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 40-148(2), indicate that n-butyl acrylate is expected to have very high to high mobility in soil(SRC). Volatilization of n-butyl acrylate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.6X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 5.45 mm Hg(3), and water solubility, 2,000 mg/L(4). n-Butyl acrylate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Utilizing the Japanese MITI test 61.3% of the theoretical BOD was reached in 2 weeks(5) suggesting that biodegradation is an important environmental fate process in soil(SRC). n-Butyl acrylate had a theoretical BOD of 56% and 40% in other biodegradation tests using OECD methods(2).AQUATIC FATE: Based on a classification scheme(1), Koc values of 40-148(2), indicate that n-butyl acrylate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.6X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 5.45 mm Hg(4), and water solubility, 2,000 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5 hours and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 17(SRC), from its log Kow of 2.36(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is not expected to be an important process(SRC) based on estimated hydrolysis half-lives of 11 and 1.1 years at pHs 7 and 8, respectively(9). n-Butyl acrylate has experimental aquatic first-order photochemical degradation rates of 5.7X10-4, 5.9X10-4, 4.7X10-4, and 4.1X10-4/sec in distilled water, river water, artificial seawater, and seawater, respectively(10), corresponding to half-lives of 20 min, 19 min, 25 min, and 28 min, respectively(SRC). Utilizing the Japanese MITI test, 61.3% of the theoretical BOD was reached in 2 weeks(11), suggesting that biodegradation is an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-butyl acrylate, which has a vapor pressure of 5.45 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase n-butyl acrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 28 hours(SRC), calculated from its rate constant of 1.4X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Vapor-phase n-butyl acrylate is also degraded in the atmosphere by reaction with ozone(SRC)the half-life for this reaction in air is estimated to be 7 hours(SRC), calculated from its rate constant of 1.8X10-18 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Experimental photodegradation rates in distilled water, river water, artificial seawater, and seawater of 5.7X10-4, 5.9X10-4, 4.7X10-4, and 4.1X10-4/sec, respectively(4), which correspond to half-lives of 20 min, 19 min, 25 min, and 28 min, respectively(SRC), suggest that n-butyl acrylate may be susceptible to direct photolysis in sunlight(SRC). |
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| 有害作用 | Lacrimator (Lachrymator) - A substance that irritates the eyes and induces the flow of tears. |
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| 暴露経路 | The substance can be absorbed into the body by inhalation and through the skin.inhalation, skin absorption, ingestion, skin and/or eye contact |
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| 生態毒性抜粋 | /AQUATIC SPECIES/ Toxicity tests were conducted using freshwater and marine fish, invertebrates, and algae. Acrylic acid effect concentrations for fish and invertebrates ranged from 27 to 236 mg/L. Effect concentrations (LC50 or EC50) for fish and invertebrates using methyl acrylate, ethyl acrylate, and butyl acrylate ranged from 1.1 to 8.2 mg/L. The chronic maximum acceptable toxicant concentration (MATC) for acrylic acid with Daphnia magna was 27 mg/L based on length and young produced per adult reproduction day and for ethyl acrylate was 0.29 mg/L based on both the reproductive and growth endpoints. |
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| Signs and Symptoms | Burning sensation. Cough. Shortness of breath. Sore throat.Redness. Pain.Abdominal pain. Nausea. Vomiting. Diarrhoea.irritation eyes, skin, upper respiratory systemsensitization dermatitisdyspnea (breathing difficulty) |
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| Effluent Concentrations | The following industrial categories have been identified as sources of emission of butyl acrylate in a screening of possible sources emitting toxic air pollutants: commercial gravure printing, plastics materials and resins, medicinals and botanicals, pharmaceutical preparations, soap and other detergents, paints and allied products, industrial organic chemicals, photographic equipment and supplies, petroleum bulk stations and terminals, nonresidential building operationsno quantitative data were reported(1). |
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| ICSC Environmental Data | The substance is toxic to aquatic organisms. |
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| Soil Adsorption/Mobility | Koc values for n-butyl acrylate have been reported as 40 in Washington clay/loam (29% sand, 42% silt, 29% clay, 3.39% organic carbon, pH 6.0), 50 in Canfield loam (45% sand, 42% silt, 13% clay, 4.58% organic carbon, pH 6.1), 97 in Ellsworth loam (35% sand, 40% silt, 25% clay, 1.42% organic carbon, pH 7.2), 148 in Tyner loamy sand (79% sand, 14% silt, 7% clay, 0.46% organic carbon, pH 5.2), and 107 in sandy loam sediment (53% sand, 28% silt, 19% clay, 1.23% organic carbon, pH 7.5)(1). According to a classification scheme(2), these Koc values suggest that n-butyl acrylate is expected to have high to very high mobility in soil. |
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| Atmospheric Concentrations | URBAN/SUBURBAN: n-Butyl acrylate was detected in ambient air samples from 1 of 8 locations near industrial sites in New Jersey and Staten Island, NY, sampled in March and May, 1976(1). The ambient concn in the air near the industrial site in Newark, NJ was 17 ug/cu m(1). |
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| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ Human skin sensitization to n-butyl acrylate was reported. Patch test concentration ranged from 0.1 to 0.5%. 6 out of 124 patients were positive, but also /it was noted/ that those results should be interpreted with caution, due to clinical history of the patients and purity of the different tested acrylates ... Another /study/ described ... a data collection of 82 patients between 1987 and 1992 suspected of occupational acrylic sensitization, showed in the patch test with 1% in petrolatum 2 patients to be sensitized to n-butyl acrylate./HUMAN EXPOSURE STUDIES/ ... In 542 dermatitis patients given covered patch tests with 1% EMA or 1% nBMA in petrolatum, one individual responded to EMA and another to both EMA and nBMA ... No reactions were seen in 22 contact dermatitis patients given 24-hr covered patch tests with esters within the category at a concentration of 1% in petrolatum ... The contact dermatitis of many of the tested individuals was attributed to (meth)acrylate exposure ... The prevalence of positive clinical challenge responses /was reported/ in dental clinicians that had been referred with dermatitis and suspected of having allergy to (meth)acrylates as 1.2% (51/4221) for MMA, 0.7% (16/2323) for EMA and 0.3% (1/347) for BMA ... The prevalence in a similar, pre-selected clinical cohort /was reported/ as 0.8% (9/1161) for MMA and 0.3% (2/625) for EMA ... The prevalence of positive clinical challenge tests in patients referred with dermatitis with previous contact with (meth)acrylates was reported as 4.8% (17/352) for MMA, 4.4% (11/246) for EMA and 0.6% (2/331) for BMA ... Cross-reactivity with common acrylates (i.e. between methacrylates and acrylates) has not been observed ... and methacrylic acid, the common hydrolysis product for these methacrylate esters, is not a contact allergen ... /Short chain alkyl-methacrylate esters//SIGNS AND SYMPTOMS/ n-Butyl acrylate ... /can/ cause allergic contact dermatitis./SIGNS AND SYMPTOMS/ The acute toxicity of the acrylates decreases with increasing molecular weight ... Human signs and symptoms following ingestion of acrylic monomers include collapse, severe respiratory difficulties, and CNS stimulation. Acute inhalation of higher concentration may cause marked irritation, salivation, conjunctival irritation, and pronounced pulmonary irritation or edema. Prolonged skin or eye contact may result in severe tissue damage. The pathology from single exposure is contrary to repeated exposure effects, which include pulmonary congestion or hemorrhage and cloudy swelling of liver and kidney. /Acrylates/For more Human Toxicity Excerpts (Complete) data for n-Butyl acrylate (10 total), please visit the HSDB record page. |
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| 大気基準 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. n-Butyl acrylate is produced, as an intermediate or a final product, by process units covered under this subpart. |
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| 輸送番号（UN） | 2348 |
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| 危険等級 | 3 |
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| 包装等級 | III |
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