炭酸ビス(3-ヒドロキシアリル)

Teratogenicity of CR-39R (diallyl diglycol carbonate) was evaluated in groups of 5 artificially inseminated New Zealand white rabbits dermally administered occluded doses of 0 (isotonic sa-line), 0.1, 0.5, 1.0, or 3.0 ml/kg/day applied 24 hrs/day gestation days (GD) 6-18. One doe dosed 3.0 ml/kg was killed in extremis GD 18, having exhibited pallor, reduced respiration, and reduced spontaneous activity. All groups showed firm dark areas at dosage sites during treatment which often scabbed afterwards. Treatments sites of all but 0.1 ml/kg showed discrete or diffuse reddening and /or swelling. Food consumption and fecal output decreased in all groups. All groups including control lost weight during treatment; the 3.0 ml/kg group lost significantly (p<0.02) more than the control. Of 3.0 ml/kg does, 3 had yellow areas on liver caudal surfaces on necropsy. Abortions or early deliveries in 0.1, 0.5, 1.0, and 3.0 ml/kg groups were 2, 0, 2, 1l, and 3, respectively. Corpora lutea and number of dead fetuses were unchanged. Intergroup variations in other uterine parameters (numbers of implants, live fetuses, fetal body weights, pre-implantation losses, and sex ratio) were not considered significant. Late resorptions were high in control and most treated groups. Of 0.1, 0.5, and 1 ml/kg groups, 3, 1, and 4 fetuses had hydrocephaly and/or abnormal limb/paw flexure.

Teratogenicity of CR-39R (diallyl diglycol carbonate) was evaluated in groups of 18 inseminated New Zealand white rabbits dermally administered occluded doses of 0 (isotonic saline), 0.1, 0.5, or 1.0, ml/kg per day applied 6 hrs gestation days (GD) 6-18. Seven high-dose does died or were killed in extremis GD 7, 8, 20, 21, and 22, having exhibited poor appetite, labored respiration, weakness, thinness, coldness, prostration, and/or yellow nasal discharge. All treated groups showed red/black areas of dose-related extent, sometimes with red secretions, at dosage sites during treatment which scabbed later. Other clinical effects were reddening of the dorsal cervical region and pinna (high dose) and reddening or swelling in the uro-genital area (mid and high dose). Food consumption and fecal output increased (dose-related) in mid and high dose groups. Mid and high dose groups lost weight GD 6-18, high dose losses continuing GD 18-24. Necropsy showed pale foci in liver (and/or firmness and/or irregular surface), heart, kidneys, and mesentery in mid and high dose groups. Stomach lesions were in all groups, especially high dose; 4 does had dark ingesta. Abortions or early deliveries in 0, 0.1, 0.5, and 1.0 ml/kg groups were 2, 3, 2, and 8, respectively. In low or mid dose groups, number of corpora lutea, implantation sites, live and dead fetuses, resorptions, fetal and litter weights, uterine weights, and pre- and post-implantation losses were similar to controls for does alive on GD 29. Does that died, littered early, or aborted had resorptions in aborta or in utero. Fetuses in mid (p<0.01) and high (p<0.001) dose groups had significantly higher incidence of small lenses, with ocular opacities in high dose groups. Major or minor visceral malformations were similar to controls. Skeletal variants included significant (p<0.05) decrease in single thirteenth ribs, and an increase in incidence of 27 presacral vertebrae (mid dose).

The case was described of a 19 year old woman employed to inject diallylgycol carbonate liquid monomer (used to manufacture high quality prescription lenses) into lens molds who developed contact dermatitis. During work, there were occasional spills of the monomer which could come in contact with the hands and arms of the worker. After 2 weeks of employment, the patient developed blisters and edema of the back of her hands, forearms, knees and thighs that required hospitalization and treatment. Although the irritant nature of the monomer was known, the workers had difficulties working with gloves and protective clothing. Patch tests carried out in ten volunteers with a 1 percent solution of diallylgycol carbonate confirmed the irritant nature of the product, in the form of a minimal or mild edema, with no vesicular reactions. Patch testing carried out in the patient to rule out the possibility of an allergic contact dermatitis revealed that she was highly sensitive to diallylgycol carbonate, a positive reaction being recorded at a concentration as low as 0.001 percent. The authors conclude that the patient developed an allergic contact dermatitis to diallylgycol carbonate, although the product is also a skin irritant.

/SRP:/ Basic Treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/

/SRP:/ Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Consider drug therapy for pulmonary edema ... . Use propaparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/