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Cosmetic ingredients (Acetamide MEA) -> CIR (Cosmetic Ingredient Review)

Humectant; Antistatic

NEEDLES (ACETONE)

BROWN, VISCOUS LIQUID

176.6 °C

350 °F OC

This chemical does not meet GHS hazard criteria for 40% (32 of 80) of reports.

Danger

H315 (51.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Chemical: Acetamide, N-(2-hydroxyethyl)-

Acetamide, N-(2-hydroxyethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetamide, N-(2-hydroxyethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 08-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/24151

Acetylethanolamine: Does not have an individual approval but may be used under an appropriate group standard

1 - Materials that, under emergency conditions, can cause significant irritation.

1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.

0 - Materials that in themselves are normally stable, even under fire conditions.

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER.

The CIR Expert Panel concluded that the ethanolamides listed subsequently are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Acetamide MEA

Safe for use in cosmetics, with qualifications

HYDROXYETHYL ACETAMIDE RATED 3 ON RABBIT EYES. /TESTED EXTERNALLY ON EYES OF RABBITS & HAVE BEEN RATED NUMERICALLY ON SCALE OF 1 TO 10 ACCORDING TO DEGREE OF INJURY OBSERVED AFTER 24 HR, PAYING PARTICULAR ATTENTION TO CONDITION OF CORNEA. MOST SEVERE INJURIES HAVE BEEN RATED 10./

WHEN INJECTED IV INTO RABBITS FOR 7 DAYS, N-ACETYLETHANOLAMINE (30-34 MG/G/DAY) DECR ASPARTATE LEVEL IN BRAIN & KIDNEY. ADMIN IN SINGLE INJECTION, N-ACETYLETHANOLAMINE INCR LEVELS OF GLUTAMATE, ASPARTATE, & GABA IN BRAIN.

N-ACETYLETHANOLAMINE (42 MG/KG) GIVEN IP TO RATS INCR GLYCOGEN & ATP IN LIVER, KIDNEYS, BRAIN, & HEART.

CIR ingredient: Acetamide MEA

Used as a plasticizer, humectant (paper products, glues, cork, and inks), and textile conditioner; [Hawley]

Pulp and Paper Processing [Category: Industry]