ビス(ヘキサメチレン)トリアミン

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

bis-Hexamethylenetriamine (CAS # 143-23-7) was evaluated for acute oral toxicity in groups of 5 Sprague-Dawley albino rats (2 or 3/sex/group) administered single undiluted doses of 316, 398, 501, and 631 mg/kg by oral gavage. Mortality occurred within 1 to 2 hours in the three highest dose groups, and an LD50 was 450 (415-485) mg/kg, as calculated by a method of E. J. de Beer. Clinical toxicity was characterized by reduced appetite, hypoactivity, rapid loss of vigor, collapse, and death. Upon necropsy of the study lethalities, hemorrhagic lungs and liver, and profound gastrointestinal inflammation were identified. The survivors of 7-day post-gavage observation exhibited no gross pathology attributable to treatment.

bis-Hexamethylenetriamine (CAS # 143-23-7) was evaluated for acute dermal toxicity in alternate solitary male or female New Zealand white rabbits administered single occluded applications of 31.6, 50.1, 79.4, 126.0, 200.0, 316.0, 1000.0, and 2000.0 mg/kg neat upon clipped, intact skin for 24 hours. An LD50 range was identified between 126.00 and 200.0 mg/kg, with each rabbit of a 200.0 mg/kg dose or higher succumbing from several hours to one day post-treatment. Reduced appetite, hypoactivity, increasing loss of vigor, collapse, and death characterized the clinical evidence of systemic toxicity. Upon necropsy, macroscopic evidence of systemic toxicity associated with treatment was identified among the decedent rabbits, including hemorrhagic lungs and liver. The study survivors of 14-day post-treatment observation exhibited no gross lesions.

bis-Hexamethylenetriamine (CAS # 143-23-7) was evaluated for eye irritation in 2 groups of 3 (2 male, 1 female) albino rabbits (strain unspecified) administered single 0.1 mL undiluted instillations into right eye conjunctival sacs for 1 minute and 24 hours, respectively. Treatment was terminated upon saline wash of the treated eyes. Determinations of irritation at 10 minutes, 1 hour, and at 3, 5, 7 and 14 days post-treatment were made based on a method of Draize, Woodard, and Calvery, the left (untreated) eyes serving as control. All instillations induced severe discomfort, with pawing, squealing, and thrashing about in the cages. One hour after rinse of the 1-minute instillation, the initial severe erythema, slight edema and copious discharge had worsened to severe erythema, moderate edema, copious discharge, and corneal dullness. Rabbits of the 24-hour treatments exhibited a similar response to unrinsed instillations by 10 minutes. Increasing corneal cloudiness in the animals of 1-minute instillations eventuated in corneal opacity and destroyed vision at 120 hours, a fate that was realized in rabbits of 24-hour treatments at 1 hour post-instillation.

Bis(hexamethylene)triamine (CAS # 143-23-7) was evaluated for primary dermal irritation in 3 male and female New Zealand white rabbits administered 0.5 mL undiluted applications upon clipped, intact skin under semi-occluded patch for 4 hours. Dermal discoloration from the sample continued to prevent appreciation of erythema at 1-hour post-dosing, although edema was noted and worsened to eschar by the 4-hour evaluation. Slight loosening of scab edges at the reaction site was reported 14 days after treatment. Based on a method of Draize, Woodard, and Calvery, the study authors classified the compound as corrosive.