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メチルアルソン酸二ナトリウム
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識別子と物理属性
| CAS No. | 144-21-8 |
|---|---|
| 分子式 | CH3AsNa2O3 |
| 平均分子量 | 183.934 g/mol |
| 単同位体質量 | 183.90935402 g/mol |
| SMILES | C[As](=O)([O-])[O-].[Na+].[Na+] |
| InChIKey | SDIXRDNYIMOKSG-UHFFFAOYSA-L |
| PubChem CID | 8947 |
| ChEMBL | CHEMBL2289061 |
| EC No. | 205-620-7 |
| DTXSID | DTXSID4032665 |
| 現地名 | メチルアルソン酸二ナトリウム |
化学・物理的性質
| 極性表面積 | 63.2 |
|---|---|
| 水素結合供与体数 | 0 |
| 水素結合受容体数 | 3 |
| 回転可能結合数 | 0 |
| 重原子数 | 7 |
| 形式電荷 | 0 |
| 複雑度 | 49.8 |
| 物質分類 | Metals -> Arsenic Compounds, OrganicCarcinogens |
| LogP（分配係数） | Kow = <10 |
| 味 | Pleasant acid taste |
| 密度 | 1.04 g/ml1.1500 |
| Color/Form | Hydrated crystals containing 5H2O or 6H2OMonoclinic spear-shaped plates from absolute alcoholWhite crystalline solid |
| 溶解度 | Soluble in methanolpractically insoluble in most organic solventsSoluble in water (300 g/l at 25 °C)In water, 4.32X10+5 mg/l @ 25 °CWater (Sparingly) |
| Corrosivity | NON-CORROSIVE TO IRON, RUBBER AND MOST PLASTICSMildly corrosive |
| Decomposition | When heated to decomposition it emits toxic fumes of /arsenic & sodium oxide/.DECOMPOSED BY STRONG OXIDIZING & REDUCING AGENTS. |
| 融点 | >355 °CMelting point 132-139 °C /Disodium methanearsonate hexahydrate/ |
| 蒸気圧 | 0.0000001 [mmHg]10-7 mm Hg @ 25 °C |
| Physical Description | Colorless hygroscopic solid[Hawley] |
| Stability/Shelf Life | DECOMPOSED BY STRONG OXIDIZING & REDUCING AGENTS./Decomposes/ slowly at elevated temperatures. Stable to hydrolysis. |
| 沸点 | 165°C |
| 外観・状態 | Solid |
| 色 | White to Off-White |
| 安定性 | Hygroscopic |
| EPAの化学物質情報 | Disodium methanearsonate (144-21-8) |
化学的特性
White Solid
安全性と法規制
| GHS 分類 | DangerH301 (95%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | Disodium methanearsonate is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)Restricted substance: Disodium methylarsonateThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| その他の安全情報 | IMAP assessments - Arsonic acid, methyl-, disodium salt: Environment tier I assessment |
| 火災の可能性 | NOT FLAMMABLEDangerous fire hazard by spontaneous chemical reaction. Ignites spontaneously in dry air. Can react vigorously with oxidizing materialse.g. air, /chloride/. |
| 有害性の概要 | A mild skin and eye irritant[HSDB] May cause irritation[MSDSonline] Most excreted unchanged[Rosenstock, p. 947] For MSMA and DSMA, developmental studies of rats and rabbits along with a two-generation reproductive study show no indication of increased susceptibilityNo evidence of carcinogenicityTarget organs are large intestines and kidneys[Reference #1] See Dimethylarsenic acid. |
| FIFRA 要件 | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Disodium methanearsonate is found on List B. Case No: 2395Pesticide type: insecticide, herbicide, rodenticideCase Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.Active ingredient (AI): Disodium methanearsonateData Call-in (DCI) Date(s): 06/14/91, 03/03/95, 10/13/95AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruitcottonseedand cottonseed hulls.If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/ |
| OSHA Standards | Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/ |
| 大気基準 | Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Disodium methanearsonate is included on this list.(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/ |
| EPA Hazardous Waste Number | D004A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/ |
| Other Hazardous Reactions | Poisonous gases are produced when heated |
| 清浄水法要件 | Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/D004A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. |
| Hazard Classes and Categories | Acute Tox. 3 (95%)Carcinogens |
| Standard Transportation Number | 49 232 11Arsenical compound nos, solid, (or) arsenical mixture, NOS, solid49 232 10Arsenical cmpd, NOS, liquid (or) arsenical mixture, NOS, liquid |
| 消火手順 | Wear goggles and self contained breathing apparatusFire extinguishing media: Dry chemical, carbon dioxide. |
| 保管条件 | Do not store near feed, food. |
| 処分方法 | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Arsenic or organo-arsenic containing wastewater treatment sludges from production of veterinary pharmaceuticals are poor candidates for incineration. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Protective clothing to prevent contact with skinchemical goggles.Avoid skin contact or breathing spray mist. ... Keep children, domestic animals off treated areas until material washes into soil. |
| Minimum Risk Level | Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134) |
| Allowable Tolerances | Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruit, 0.35 ppmcottonseed, 0.7 ppmand cottonseed hulls, 0.9 ppm.Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue2 ppm in uncooked edible by-products& 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/ |
| Permissible Exposure Limit (PEL) | 0.5 [mg/m3], as As |
| Personal Protective Equipment (PPE) | Goggles or face shield, rubber or neoprene gloves, rubber apron. |
| Other Standards Regulations and Guidelines | ... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu mRomania and Switzerland, 0.2 mg/cu mSweden 0.05 mg/cu mand Italy 0.25 mg/cu m. /Arsenic and sol cmpd/ |
| Treatment | Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20) |
| 健康影響 | Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) |
| 生態毒性値 | LC50 BLUEGILL SUNFISH (LEPOMIS MACROCHIRUS) > 1000 PPM/48 HR/FRESH WATER /CONDITIONS OF BIOASSAY NOT SPECIFIED/ |
| 環境中動態 | ... FOUND RAPID LOSS OF HERBICIDAL ACTIVITY FROM DSMA APPLIED TO BOSKET SILT LOAM. MOST MARKED REDUCTION IN TOXIC RESIDUES OCCURRED BETWEEN INITIAL PLANTING DATE AND 16-WEEK REPLANTING DATE.TERRESTRIAL FATE: Organoarsenicals, such as dimethylarsinic acid, methanearsonic acid, monosodium and disodium salts, and sodium cacodylate are adsorbed by clay soils. After rapid initial adsorption, changes occur which result in the redistribution of dimethylarsinic acid into a less soluble form associated with aluminium in the soil. Downward leaching of the methanearsonic acid salts has also been reported. The methanearsonic acid salts and dimethylarsinic acid are fixed by iron and aluminium in the soil, although not as strongly as inorganic arsenate.REACTION OF ... DSMA ... EXAMINED IN ... PLANTS ... SINGLE RADIOACTIVE CMPD ... FOUND /IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS LEGUMINOSAE)/ IN HOT 80% ETHANOL EXTRACT. RF WAS 0.59 COMPARED TO 0.66 FOR STANDARD DSMA. CHEM ANALYSIS REVEALED THAT C-AS BOND REMAINED INTACT. |
| 暴露経路 | Oral (L2)inhalation (L2)dermal (L2) |
| 毒性の概要 | Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) |
| Signs and Symptoms | Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1). |
| Soil Adsorption/Mobility | TYPE OF CLAY MINERAL MAY BE RESPONSIBLE FOR DIFFERENT FIXATION TENDENCIES ... KAOLINITE REMOVED MUCH MORE DSMA FROM SOLN THAN DID VERMICULITE. SMALLER SIZE FRACTIONS OF AUGUSTA SILT LOAM ... ABSORBED LARGER PERCENTAGES OF MAA /METHANEARSONIC ACID/ PRESENT IN SOLUTION.PHYTOTOXICITY IS ... AFFECTED BY LEACHING OF DSMA. IF ARSONATE IS APPLIED WITHIN 2 HR OF RAIN, LITTLE ABSORPTION WILL OCCUR AND LEACHING OF MAA /METHANEARSONIC ACID/ PROCEEDS.... FOUND NO LEACHING OF DSMA IN DECATUR CLAY LOAM, WHILE 52% ... RECOVERED IN THE TWENTY 1 IN INCREMENTS OF LEACHATE FROM NORFOLK LOAMY SAND. MOVEMENT THROUGH NORFOLK LOAMY SAND OCCURRED AS BAND OF HIGH FRONTAL CONCN WHICH ... DECREASED IN DIRECTION OF ZONE OF APPLICATION. |
| Human Toxicity Excerpts | COMPOUNDS INCLUDED METHANEARSONIC ACID & ITS SODIUM SALTS9/34 CASES SHOWED SYSTEMIC SYMPTOMS & REMAINDER HAD EYE & SKIN IRRITATION.ORGANIC ARSENICALS INCLUDE DISODIUM METHYLARSONATE ... AND AMINE METHYLARSONATE. TOXICITY OF THESE CMPD TO HUMANS IS CONSIDERABLY LESS THAN ... INORGANIC ARSENICALSHOWEVER THEY ARE HARMFUL IF INHALED, SWALLOWED, OR IF THEY COME IN CONTACT WITH EYES OR SKIN.Toxic by ingestion and inhalation. |
| Environmental Biodegradation | ... NORFOLK LOAMY SAND SAMPLES (WITH AND WITHOUT ORGANIC MATTER ADDED) SHOWED INCREASED DSMA DECOMPOSITION RELATIVE TO SOIL ORGANIC MATTER. THIS SUGGESTS ADAPTATION OF MICROBIAL POPULATION TO METABOLIZE METHYL CARBON OF MAA /METHANEARSONIC ACID/. |
| Sediment/Soil Concentrations | The sorption of arsenic, phosphate, disodium methanearsonate, and the sodium salt of cacodylic acid by 16 Mississippi river alluvial flood plain soils is measured in a slurry experiment in which initial pH and molar solution concn for all four solutes are identical. Sorption of the two organoarsenical herbicides is strongly correlated with arsenate and phophate sorption, and sorption of all four species is strongly correlated with clay and iron oxide contents of the soils. |
| Carcinogen Classification | 3, not classifiable as to its carcinogenicity to humans. (L135) |
| 州飲料水ガイドライン | (AZ) ARIZONA 10 ug/L /Arsenic/(CT) CONNECTICUT 10 ug/l /Arsenic/ |
| Federal Drinking Water Standards | 10 ug/l /Arsenic/ |
| RTECS 番号 | PA2275000 |
| 輸送番号（UN） | 2759 |
| 危険文句（R） | 22-50/53-23/25 |
| 危険表示 | Xn,N,T |
| 安全措置（S） | 26-61-60-45-28-20/21 |
| 危険等級 | 6.1(b) |
| 包装等級 | III |
| 有害物質データ | 144-21-8(Hazardous Substances Data) |
用途
使用
Methylarsonic acid is used as herbicide.