テトラキス(N,N-ジメチルジチオカルバミド酸)セレン(IV)

This chemical does not meet GHS hazard criteria for 100% (5 of 5) of all reports.

Not Classified

Aggregated GHS information provided per 5 reports by companies from 1 notifications to the ECHA C&L Inventory.

Contains selenium, which is toxic; [Sax] May cause irritation; Inhalation of dust and ingestion may be harmful; [MSDSonline] As indicated by its synonym, selenium dimethyldithiocarbamate, methyl selenac is related to the dithiocarbamate fungicides. Several of the dialkyldithiocarbamates are known skin sensitizers; See Carba mix. See Maneb. See Selenium.

Toxicology Review: Clinical Toxicology 5 (2): 175 (1972)

WHO; Evaluation of The Available Toxicity Data On Selenium (1987). Properties and analysis; sources, levels and transport in the environment; human exposure; metabolism; animal studies; effects on man; evaluation of the health risks; quantitative assessment of exposure.

NTIS; Govt Reports Announcements & Index (GRA&I), Issue 14 (1987). This bibliography contains citations concerning the toxicity, carcinogenicity, environmental pollution, and other hazards and adverse effects of selenium. The detection, characterization, analytical methods, and removal from the environment are discussed. Pollution from coal fired and geothermal power plants are considered. (This updated bibliography contains 349 citations, none of which are new entries to the previous edition.)

Najael; Revue g'en'erale de s'ecurite - RGS 63: 65-72 (1987). Information note on the harmful effects of selenium compounds. Physical and chemical properties of selenium and its principal compounds; uses; pathology and toxicology (irritation of the skin and mucous membranes; these irritations are compensable under French law); radioactive selenium; fire hazards; French regulations; protection.

For more Special Reports (Complete) data for SELENIUM DIMETHYLDITHIOCARBAMATE (10 total), please visit the HSDB record page.

D010; A solid waste containing selenium (such as selenium dimeethyldithiocarbamate) may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Selenium dimethyldithiocarbamate is included on this list.

(AZ) ARIZONA 45 ug/l /Selenium/

(ME) MAINE 10 ug/l /Selenium/

(MN) MINNESOTA 30 ug/l /Selenium/

(CT) CONNECTICUT 10 ug/l /Selenium/

The worker should immediately wash the skin when it becomes contaminated. /Selenium/

Work clothing that becomes wet or significantly contaminated should be removed and replaced. /Selenium/

0.2 [mg/m3], as Se

8 hr Time Weighted Avg (TWA): 0.2 mg/cu m. /Selenium and compounds, as Se/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Selenium and compounds, as Se/

Wear appropriate personal protective clothing to prevent skin contact. /Selenium/

Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. (Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.) /Selenium/

Recommendations for respirator selection. Max. concn for use: 1 mg/cu m. Respirator Class(es): Any dust and mist respirator. If not present as a fume. May require eye protection. Any dust, mist, and fume respirator. May require eye protection. Any air-purifying, full-facepiece respirator with a high-efficiency particulate filter. Any powered, air-purifying respirator with a dust and mist filter. If not present as a fume. May require eye protection. Any powered, air-purifying respirator with a dust, mist, and fume filter. May require eye protection. Any supplied-air respirator. May require eye protection. Any self-contained breathing apparatus with a full facepiece. /Selenium/

Chronic oral exposure to high concentrations of selenium compounds can produce a disease called selenosis. The major signs of selenosis are hair loss, nail brittleness, and neurological abnormalities (such as numbness and other odd sensations in the extremities). Animal studies have shown that selenium may also affect sperm production and the female reproductive cycle. (L619)

Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration of sulfur is low. Inactivation of the sulfhydryl enzymes necessary for oxidative reactions in cellular respiration, through effects on mitochondrial and microsomal electron transport, might contribute to acute selenium toxicity. Selenomethionine (a common organic selenium compound) also appears to randomly substitute for methionine in protein synthesis. This substitution may affect the structure and functionability of the protein, for example, by altering disulfide bridges. Inorganic forms of selenium appear to react with tissue thiols by redox catalysis, resulting in formation of reactive oxygen species and causing damage by oxidative stress. (L619)

Short-term oral exposure to high concentrations of selenium may cause nausea, vomiting, and diarrhea. Brief exposures to high levels of elemental selenium or selenium dioxide in air can result in respiratory tract irritation, bronchitis, difficulty breathing, and stomach pains. Longer-term exposure to either of these air-borne forms can cause respiratory irritation, bronchial spasms, and coughing. (L619)

Methyl selenac

Group 3: Not classifiable as to its carcinogenicity to humans

D010; A solid waste containing selenium (such as selenium dimeethyldithiocarbamate) may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Selenium dimethyldithiocarbamate is included on this list.

(AZ) ARIZONA 45 ug/l /Selenium/

(ME) MAINE 10 ug/l /Selenium/

(MN) MINNESOTA 30 ug/l /Selenium/

(CT) CONNECTICUT 10 ug/l /Selenium/

Selenium may be absorbed through inhalation and ingestion, while some selenium compounds may also be absorbed dermally. Once in the body, selenium is distributed mainly to the liver and kidney. Selenium is an essential micronutrient and is a component of glutathione peroxidase, iodothyronine 5'-deiodinases, and thioredoxin reductase. Organic selenium is first metabolized into inorganic selenium. Inorganic selenium is reduced stepwise to the intermediate hydrogen selenide, which is either incorporated into selenoproteins after being transformed to selenophosphate and selenocysteinyl tRNA or excreted into the urine after being transformed into methylated metabolites of selenide. Elemental selenium is also methylated before excretion. Selenium is primarily eliminated in the urine and feces, but certain selenium compounds may also be exhaled. (L619)

Used as a vulcanization accelerator; [HSDB]

Vulcanization accelerator

Selenium rarely occurs in its elemental state in nature and is usually found in sulfide ores such as pyrite, partially replacing the sulfur in the ore matrix. It may also be found in silver, copper, lead, and nickel minerals.

(1972) PROBABLY GREATER THAN 4.54X10+5 GRAMS

(1975) PROBABLY GREATER THAN 4.54X10+5 GRAMS

REACTION OF DIMETHYLAMINE, CARBON DISULFIDE AND SELENIUM DIOXIDE IN AN ALCOHOLIC SOLUTION.

...PREPN OF WATER-INSOLUBLE DIALKYLDITHIOCARBAMATE METAL SALTS IS PPTN OF METAL SALT FROM AQ PREPN OF SODIUM DIALKYLDITHIOCARBAMATE.

Carbamodithioic acid, N,N-dimethyl-, tetraanhydrosulfide with orthothioselenious acid: ACTIVE

COMMERCIAL PRODN...FIRST REPORTED IN US IN 1946... IN 1974, ONLY 1 MFR REPORTED PRODN... IT IS NOT PRODUCED COMMERCIALLY IN EUROPE.

METHYL SELENAC IS USED IN RUBBER-PROCESSING INDUST AS ACCELERATOR TO PRODUCE DESIRED PHYSICAL PROPERTIES IN VULCANIZED RUBBER IN SHORTER CURING TIME & AT LOWER SULFUR LEVELS THAN WITH CONVENTIONAL ACCELERATORS. IT IS USED IN COMPOUNDING HEAT-RESISTANT NATURAL & SYNTHETIC RUBBERS.