Diaqua((P,P'-methylenebis(phosphonato-kappaO))(4-))technetium-99Tc
基本情報
- CAS
121524-79-6- 標準SMILES
O.O.O=P([O-])([O-])CP(=O)([O-])[O-].[99Tc+4]- InChIKey
IUPNVOAUFBLQME-SGNQUONSSA-J- 分子式
- CH6O8P2Tc
- 平均分子量
- 306.91 g/mol
- 単同位体質量
- 306.860041
概要
Technetium (99mTc) medronic acid is a pharmaceutical product used in nuclear medicine imaging. It is composed of a technetium ion complexed with medronic acid, a type of bisphosphonate. Like other bisphosphonates used in the treatment of osteoporosis, medronic acid binds to the hydroxyapatite crystals within bone, and in this way localizes the drug to bone for delineation of areas of altered osteogenesis. Following intravenous injection, single photon emission computed tomography (SPECT) is performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99.
名称と識別子
- 優先名称
- Diaqua((P,P'-methylenebis(phosphonato-kappaO))(4-))technetium-99Tc
- IUPAC
- dioxido-oxo-(phosphonatomethyl)-λ5-phosphane;technetium-99(4+);dihydrate
名称と別名
Tc-99m MdpDTXSID601026655TECHNETIUM Tc 99m MEDRONATETechneScan MDPTc-99 MedronateMDP KitAN-MDPDraximage MDP-25121524-79-6MDP-BRACCO99mTc-MDPTechnetium Tc 99M Mpi Mdp
名称をさらに表示
Technetium ((sup 99m)Tc) MethylenediphosphonateTechnetium methylene diphosphonate99mTc-Methylene diphosphonateTc-99m Methylene DiphosphonateX89XV46R07TECHNETIUM TC-99M MEDRONATETechnetium (99mTc) methylenediphosphonateTechnetium Tc 99m Methylenediphosphonate
データベース識別子
- CAS
121524-79-6- PubChem CID
- 90478980
- DTXSID
DTXSID601026655- ChEMBL
CHEMBL1200931
物性
構造計算による物性
- 極性表面積
- 128 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 8
- 回転可能結合数
- 0
- 重原子数
- 12
- 形式電荷
- 0
- 複雑度
- 128
実験および物理化学的性質
Human Drugs
Breast Feeding; Lactation; Milk, Human; Radiopharmaceuticals; Technetium Compounds; Diagnostic Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
毒性情報
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
化学と産業
薬理情報
Biological Half-LifeTechnetium Tc-99m decays by isomeric transition with a physical half-life of 6.02 hours.
FDA Pharmacological Classification
X89XV46R07
TECHNETIUM TC-99M MEDRONATE
Established Pharmacologic Class [EPC] - Radioactive Diagnostic Agent
Mechanisms of Action [MoA] - Radiopharmaceutical Activity
Technetium tc-99m medronate is a Radioactive Diagnostic Agent. The mechanism of action of technetium tc-99m medronate is as a Radiopharmaceutical Activity.
TC 99M MEDRONATE
MeSH Pharmacological ClassificationCompounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Absorption, Distribution and Excretion
When injected intravenously, Technetium Tc 99m Medronate is rapidly cleared from the blood; about 50% of the dose is accumulated and retained by the skeleton, while the remaining 50% is excreted in the urine within 24 hours. About 10% of the injected dose remains in the blood at 1 hour post-injection, 5% at 2 hours, and less than 1% remains at 24 hours. Following intravenous administration of Technetium Tc 99m Medronate, skeletal uptake occurs as a function of blood flow to bone and bone efficiency in extracting the complex.
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