2-アミノエタンチオール塩酸塩
2-アミノエタンチオール塩酸塩 · 2-アミノ-1-エタンチオール·塩酸 · システアミン·塩酸 · 2-メルカプトエチルアミン·塩酸塩 · 2-アミノエタンチオール·塩酸塩 · 2-アミノエタンチオール·塩酸 · システアミン塩酸塩 · 2-アミノエタン-1-チオール·塩酸塩
識別子と物理属性
| CAS No. | 156-57-0 |
|---|---|
| 分子式 | C2H7NS.ClH |
| 平均分子量 | 113.61 g/mol |
| 単同位体質量 | 113.00659794 g/mol |
| SMILES | Cl.NCCS |
| InChIKey | OGMADIBCHLQMIP-UHFFFAOYSA-N |
| PubChem CID | 9082 |
| ChEMBL | CHEMBL1256137 |
| ChEBI | CHEBI:201814 |
| EC No. | 205-858-1 |
| DTXSID | DTXSID8045779 |
| 現地名 | 2-アミノエタンチオール塩酸塩 |
化学・物理的性質
| 極性表面積 | 27 |
|---|---|
| 水素結合供与体数 | 3 |
| 水素結合受容体数 | 2 |
| 回転可能結合数 | 1 |
| 重原子数 | 5 |
| 形式電荷 | 0 |
| 複雑度 | 10 |
| 物質分類 | Biological Agents -> Amino Acids and Derivatives |
| 化粧品 | ReducingAntioxidant |
| 溶解度 | >17 [ug/mL] (The mean of the results at pH 7.4)H2O: 1M at20℃、透明、無色非常に溶けやすい |
| Human Drugs | FDA approved drugs -> Active ingredientEMA approved medicines: Human medicine (Orphan designations) |
| Physical Description | Solid[Merck Index] White hygroscopic crystals[Alfa Aesar MSDS] |
| 融点 | 67-71 °C |
| 沸点 | 238.5℃[at 101 325 Pa] |
| 密度 | 0.75 |
| 蒸気圧 | 5.333Pa at 25℃ |
| 屈折率 | 1.6100 (estimate) |
| 貯蔵条件 | 2-8°C |
| 外観・状態 | 結晶性粉末またはペレット |
| 色 | 白い |
| pH | 3.3-5.0 (400g/l, H2O, 20℃) |
| 由来生物 | synthetic (organic) |
| Merck | 14,2779 |
| BRN | 3590083 |
| 安定性 | 安定していますが、吸湿性があります。強力な酸化剤とは相容れない。 |
| 化粧品成分の機能 | 抗酸化物質還元剤ヘアウェーブとヘアストレート |
| InChI | 1S/C2H7NS.ClH/c3-1-2-4/h4H,1-3H21H |
| InChIKey | OGMADIBCHLQMIP-UHFFFAOYSA-N |
| SMILES | Cl[H].NCCS |
| LogP（分配係数） | -2.14 at 25℃ |
| CAS データベース | 156-57-0(CAS DataBase Reference) |
| EPAの化学物質情報 | Cysteamine hydrochloride (156-57-0) |
| Absorption | cut-off at 270nm in H2O at 1M |
化学的特性
White Solid
安全性と法規制
| GHS 分類 | This chemical does not meet GHS hazard criteria for 6.1% (17 of 278) of reports.WarningH302 (92.1%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 278 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 規制情報 | Chemical: Ethanethiol, 2-amino-, hydrochlorideStatus: Active Update: 28-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25700Ethanethiol, 2-amino-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| 有害性の概要 | Causes burns to skin and eyesA respiratory tract irritant[ECHA REACH Registrations] Teratogenicity observed in oral study of rats in the absence of maternal toxicityDevelopmental toxicity observed in intraperitoneal study of mice[Shepard's Catalog of Teratogenic Agents] A skin and strong eye irritantHarmful by ingestion[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Acute Tox. 4 (92.1%) |
| 有害作用 | Dermatotoxin - Skin burns. |
| F | 1-3-10-13 |
| 水環境危害等級（WGK） | 3 |
| TSCA 収載状態 | TSCA listed |
| RTECS 番号 | KJ0200000 |
| 輸送番号（UN） | UN 3335 |
| 毒性 | LD50 orally in Rabbit: 642 mg/kg |
| 税関コード | 29309070 |
| 危険文句（R） | 22-36/37/38 |
| 化審法 | (9)-1422 |
用途
説明
Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
使用
Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
一般的な説明
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.
製法・合成法
純化方法
Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]