Fenfluramine Hydrochloride

HCID 91452CAS 16105-77-4

基本情報

標準SMILES: CCNC(C)Cc1cccc(C(F)(F)F)c1.Cl
InChIKey: ZXKXJHAOUFHNAS-UHFFFAOYSA-N
分子式: C12H17ClF3N
平均分子量: 267.72 g/mol
単同位体質量: 267.10016188

概要

Fenfluramine Hydrochloride is the hydrochloride salt of fenfluramine, an amphetamine derivative and a sympathomimetic stimulant with appetite-suppressant properties. Fenfluramine, which was part of the Fen-Phen anti-obesity medication, stimulates the release of serotonin from vesicular storage, and modulates serotonin transporter function. Since serotonin regulates mood and appetite, among other functions, increased serotonin level results in a feeling of fullness and loss of appetite.

名称と識別子

優先名称: Fenfluramine Hydrochloride
IUPAC: N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;hydrochloride
英語名: Fenfluramine hydrochloride
分子式: C12H17ClF3N
分子量: 267.72

名称と別名

Fenfluramine hydrochlorideFenfluramine HClGanal404-82-0PondiminPonderax pacapsAHR-3002HHR-9651-(3-Trifluoromethylphenyl)-2-ethylaminopropane hydrochloride3KC089243PN-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochlorideDTXSID30936444

名称をさらに表示

(+-)-fenfluraminechlorideFEBFLURAMINE HYDROCHLORIDEZXKXJHAOUFHNAS-UHFFFAOYSA-Ndl-fenfluraminehydrochlorideracemicfenfluraminehydrochloride(±)-Fenfluramine hydrochloride solution(±)-Fenfluramine solution hydrochloridefenfluramine hydrochloride*methanol solutionFENFLURAMINE HYDROCHLORIDE--DEA*SCHEDULE IV ITEM

Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, hydrochlorideCHEBI:59729RefChem:56386DTXCID901365052206-968-2dl-Fenfluramine hydrochloride16105-77-4Racemic fenfluramine hydrochloride

データベース識別子

CAS: 16105-77-4、404-82-0
PubChem CID: 91452
DTXSID: DTXSID30936444
ChEMBL: CHEMBL2106217
UNII: 3KC089243P
EC Number: 206-968-2、623-877-7

物性

構造計算による物性

極性表面積: 12 Å²
水素結合供与体数: 2
水素結合受容体数: 4
回転可能結合数: 4
重原子数: 17
形式電荷: 0
複雑度: 203

実験および物理化学的性質

Human Drugs · 3 件

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine (Orphan designations)

FDA approved drugs -> Active ingredient

物理化学的性質

融点: 166 C · 166 C
闪点: 11 °C · 11 °C
貯蔵温度: 2 · 2-8°C

安全と法規制

GHS分類

GHS Classification · 6 件

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory.

Danger

H300 (50%): Fatal if swallowed [Danger Acute toxicity, oral]

危険有害性情報

Regulatory InformationBenzeneethanamine, N-ethyl-.alpha.-methyl-3-(trifluoromethyl)-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Benzeneethanamine, N-ethyl-.alpha.-methyl-3-(trifluoromethyl)-, hydrochloride: Human health tier I assessment

Hazard Classes and Categories · 2 件

Acute Tox. 2 (50%)

Acute Tox. 3 (100%)

安全データ

wgk: 3
rtecs: DA0295500
ridadr: UN 2811 6.1/PG 3
risk_code: 25-39/23/24/25-23/24/25-11-36/37/38
hazard_code: T,F,Xi
safety_code: 7-16-36/37-45-28-22-36-26

化学と産業

薬理情報

MeSH Pharmacological Classification · 2 件

Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.

Compounds that specifically inhibit the reuptake of serotonin in the brain.

サプライヤー3 社

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