酸化鉄の糖酸塩
Succharated ferric oxide
基本情報
- CAS
8047-67-4- 標準SMILES
O.O.O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Na+].[Na+].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[OH-]- InChIKey
ADQSUDSYBZBMFT-JMMWHMDLNA-H- 分子式
- C12H29Fe5Na2O23
- 平均分子量
- 866.5 g/mol
- 単同位体質量
- 866.76418
概要
Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron sucrose is more preferred in chronic kidney disease patients.
名称と識別子
- 優先名称
- Succharated ferric oxide
- IUPAC
- disodium;(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;pentakis(iron(3+));octakis(oxygen(2-));hydroxide;trihydrate
- 現地名
- 酸化鉄の糖酸塩
- 英語名
- Iron saccharate
- 分子式
- C18H24Fe2O24
- 分子量
- 736.06
名称と別名
Succharated ferric oxideRefChem:1099121Sucroferric oxyhydroxideFerriveninFeojectinVenoferrumEnciferFerijetHippironProferrinSucroferVelphoro
名称をさらに表示
酸化鉄の糖酸塩酸化鉄糖酸塩酸化の糖酸サッカラート化酸化鉄鉄サッカラート含糖酸化鉄スクロオキシ水酸化鉄VenoferIronSucroseIron sucrose liquidIRON (III) OXIDE, SACCHARATEDXI 921
IvironFesinFerum HausmannFerrum VitisNeo-ferrumFerosoft SFe-backFerplex SS
データベース識別子
- CAS
8047-67-4- PubChem CID
- 91663255
物性
構造計算による物性
- 極性表面積
- 202 Ų
- 水素結合供与体数
- 12
- 水素結合受容体数
- 23
- 回転可能結合数
- 5
- 重原子数
- 42
- 形式電荷
- 0
- 複雑度
- 395
実験および物理化学的性質
Human Drugs
Breast Feeding; Lactation; Milk, Human; Ferric Compounds; Hematinics; Iron Compounds
Breast Feeding; Lactation; Milk, Human; Ferric Compounds; Iron Compounds
EMA approved medicines: Human medicine
物理化学的性質
- 融点
- 168 · 168-171°C
- 貯蔵温度
- Refrigerator
- 溶解性
- 水（少々）
- 外見
- 個体
- 色
- ブラウン～ダークブラウン
- InChI
- InChI=1/3C6H10O8.2Fe/c3*7-1(3(9)5(11)12)2(8)4(10)6(13)14;;/h3*1-4,7-10H,(H,11,12)(H,13,14);;/q;;;2*+3/p-6/t3*1-,2-,3-,4+;;/s3
- InChIKey
- ADQSUDSYBZBMFT-JMMWHMDLNA-H
- CAS データベース
- 8047 · 8047-67-4(CAS DataBase Reference)
- EPAの化学物質情報
- Iron saccharate (8047-67-4)
化学的性質
化学的特性Brown solid
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
毒性情報
Effects During Pregnancy and Lactation
◉ Summary of Use during Lactation
◉ Summary of Use during Lactation
安全データ
- 毒性
- LD50 in mice (mg Fe/kg): >2500 orally; >200 i.v. (Geisser)
- hs_code
- 29400090
化学と産業
薬理情報
ATC Code
V - Various
QV - Various
Protein BindingIt binds with transferrin.
PharmacodynamicsSignificant increases in serum iron and serum ferritin and significant decreases in total iron binding capacity occurred four weeks from the initiation of iron sucrose treatment.
Mechanism of Action
Following intravenous administration, iron sucrose is dissociated into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells. The iron is then incorporated into hemoglobin as the cells mature into red blood cells.
Biological Half-Life6 hours.
Metabolism/MetabolitesFollowing IV administration, dissociated into iron and sucrose by the reticuloendothelial system.
FDA Pharmacological Classification
SUCROFERRIC OXYHYDROXIDE
Phosphate Binder [EPC]; Phosphate Chelating Activity [MoA]
Absorption, Distribution and Excretion
The intravensously administered iron sucrose injection would result rapidly in high serum iron levels. Maximum measured levels occured after 10 min of injection with an average of 30.00 mg/l.
Renal elimination of iron contributed very little to the total elimination (in average less than 5%). While, renal elimination of sucrose accounts for 68-75% of the administered dose after 4 and 24 hours respectively.
Vd is 7.3 L
Total body clearance is 20.5 ml/min.
用途と製造
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