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フルメトリン

Flumethrin

HCID 91702
ノート反応

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基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
69770-45-2
標準SMILES
CC1(C)C(C=C(Cl)c2ccc(Cl)cc2)C1C(=O)OC(C#N)c1ccc(F)c(Oc2ccccc2)c1
InChIKey
YXWCBRDRVXHABN-UHFFFAOYSA-N
分子式
C28H22Cl2FNO3
平均分子量
510.4 g/mol
単同位体質量
509.0960771

名称と識別子

優先名称
Flumethrin
IUPAC
[cyano-(4-fluoro-3-phenoxyphenyl)methyl] 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropane-1-carboxylate
現地名
フルメトリン
英語名
Flumethrin
分子式
C28H22Cl2FNO3
分子量
510.38

名称と別名

BayticolBayvarolFlumetrinDTXSID8058166FCR-2769BAY V1 6045BAY-V1-6045CHEBI:39361Cyano(4-fluoro-3-phenoxyphenyl)methyl 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropanecarboxylateRefChem:599351DTXCID4031934cyano(4-fluoro-3-phenoxyphenyl)methyl 3-(2-chloro-2-(4-chlorophenyl)ethenyl)-2,2-dimethylcyclopropanecarboxylate
名称をさらに表示
フルメトリン3-[2-クロロ-2-(4-クロロフェニル)エテニル]-2,2-ジメチルシクロプロパンカルボン酸シアノ(4-フルオロ-3-フェノキシフェニル)メチルフルメトリン標準品CS_N-13139-100MG_フルメトリンシアノ(4-フルオロ-3-フェノキシフェニル)メチル 3-[2-クロロ-2-(4-クロロフェニル)エテニル]-2,2-ジメチルシクロプロパン-1-カルボキシラートバイチコールFlumioxazineFCR 2769Bay V1-6045FlufenthrinFluorobenthrinFlumethrin 95%Flumethrin SolutionFlumethrin in Methanol
alpha-cyano-(4-fluoro-3-phenoxy)benzyl-3-(2-chloro-2-(4-chlorophenyl)ethenyl)-2,2-dimethylcyclopropanecarboxylate274-110-4cyano(4-fluoro-3-phenoxyphenyl)methyl 3-(2-chloro-2-(4-chlorophenyl)ethenyl)-2,2-dimethylcyclopropane-1-carboxylate2O051W13LH69770-45-2Flumethrin3-[2-Chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropanecarboxylic acid cyano(4-fluoro-3-phenoxyphenyl)methyl ester; Bayticol; Bayticol Pour-on; Bayvarol; FCR 2769; FlumethrinBayticol; Bayticol Pour-on; Bayvarol; FCR 2769

物性

構造計算による物性補完中

XLogP
7.6
極性表面積
59.3 Ų
水素結合供与体数
0
水素結合受容体数
5
回転可能結合数
8
重原子数
35
形式電荷
0
複雑度
825

物理化学的性質

融点
25 °C · <25 °C
沸点
593.6 · 593.6±50.0 °C(Predicted)
比重(密度)
1.342 · 1.342±0.06 g/cm3(Predicted)
屈折率
25 · nD25 1.5831
闪点
104 °C · 104 °C
貯蔵温度
0 · 0-6°C
溶解性
Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly, Sonicated)
JECFA Number
85 · 85
主な用途
農業環境
InChI
InChI=1S/C28H22Cl2FNO3/c1-28(2)21(15-22(30)17-8-11-19(29)12-9-17)26(28)27(33)35-25(16-32)18-10-13-23(31)24(14-18)34-20-6-4-3-5-7-20/h3-15,21,25-26H,1-2H3
InChIKey
YXWCBRDRVXHABN-JCMHNJIXSA-N
SMILES
C1(C(OC(C#N)C2=CC=C(F)C(OC3=CC=CC=C3)=C2)=O)C(C=C(Cl)C2=CC=C(Cl)C=C2)C1(C)C
CAS データベース
69770 · 69770-45-2(CAS DataBase Reference)
EPAの化学物質情報
3 · Cyclopropanecarboxylic acid, 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethyl-, cyano(4-fluoro-3-phenoxyphenyl)methyl (69770-45-2)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 6 件

Danger

H300 (34.7%): Fatal if swallowed [Danger Acute toxicity, oral];H301 (65.3%): Toxic if swallowed [Danger Acute toxicity, oral];H310 (34.7%): Fatal in contact with skin [Danger Acute toxicity, dermal];H311 (41.6%): Toxic in contact with skin [Danger Acute toxicity, dermal];H315 (41.6%): Causes skin irritation [Warning Skin corrosion/irritation];H317 (41.6%): May cause an allergic skin reaction [Warning Sensitization, Skin];H319 (76.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H330 (26.7%): Fatal if inhaled [Danger Acute toxicity, inhalation];H331 (38.6%): Toxic if inhaled [Danger Acute toxicity, inhalation];H335 (23.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H360 (34.7%): May damage fertility or the unborn child [Danger Reproductive toxicity];H370 (34.7%): Causes damage to organs [Danger Specific target organ toxicity, single exposure];H372 (34.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure];H400 (23.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard];H410 (58.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P320, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 101 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory InformationFlumethrin: HSNO Approval: HSR003432 Approved with controls

化学と産業

薬理情報

ATC CodeQP - Antiparasitic products, insecticides and repellents;QP53 - Ectoparasiticides, insecticides and repellents;QP53A - Ectoparasiticides for topical use, incl. insecticides;QP53AC - Pyrethrins and pyrethroids;QP53AC05 - Flumethrin
Metabolism/Metabolites · 1 件

The highest concentration is found in the liver, but high concentrations were also found in the spleen, kidney, lung, adrenal cortex, cartilage, bone marrow, pineal gland, pituitary, and subcutaneous adipose tissue; the lowest concentrations are found in the central nervous system. Flumethrin is excreted in the urine or the feces as unchanged compound or the metabolite, 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethylcyclopropanecarboxylic acid, flumethrin acid. 3-(4'-hydroxy-phenoxy)-4-fluorobenzoic acid and 3-phenoxy-4-fluorobenzoic acid can further be found in the urine as well as their glycine conjugates. The phenyl ring may be hydroxylated and, following ester bond hydrolysis, the cyano group is converted to SCN- and carbon dioxide and 3-phenoxybenzaldehyde is oxidized to the carboxylic acid. The resultant acids and phenols can then conjugate with glucuronic acid, sulfate, and/or amino acids. (L885)

用途と製造

UsesPyrethroids are used as insecticides. (L857)
Household ProductsInformation on 3 consumer products that contain Flumethrin in the following categories is provided:;• Pet Care
Use ClassificationVeterinary Drug -> INSECTICIDE; Veterinary Drug -> -> JECFA Functional Classes
応用分野 · 2 件

説明Flumethrin: an ectoparasiticide.Flumethrin is an ectoparasiticide that belongs to the group of α-cyano-pyrethroids and has been registered in EU member states for use on companion and food-producing animals since 1986. These chemicals have been combined in a slow-release matrix collar formulation incorporating 10% imidacloprid (w/w) and 4.5% flumethrin (w/w). The imidacloprid component of the collar is aimed at the treatment and control of fleas and lice, and the flumethrin component is aimed at the treatment and control of ticks and mites. The medicated collar is expected to provide sustained protection over eight months to dogs exposed to ticks, fleas and lice[1-2].

関連反応

1 件
反応記録を作成
HRID 2130171 の反応式
HRID 2130171生成物としてTraining data from https://doi.org/10.1039/C8SC04228D (4/10)

化合物ノート

読み込み中…

このページの内容基本情報名称と識別子物性安全と法規制化学と産業関連反応化合物ノート

データベース識別子

CAS
69770-45-2
PubChem CID
91702
DTXSID
DTXSID8058166
ChEMBL
CHEMBL2107248
EC Number
274-110-4
Other Safety Information · 1 件

IMAP assessments - Cyclopropanecarboxylic acid, 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethyl-, cyano(4-fluoro-3-phenoxyphenyl)methyl ester: Environment tier I assessment;IMAP assessments - Cyclopropanecarboxylic acid, 3-[2-chloro-2-(4-chlorophenyl)ethenyl]-2,2-dimethyl-, cyano(4-fluoro-3-phenoxyphenyl)methyl ester: Human health tier I assessment

Hazard Classes and Categories · 2 件

Acute Tox. 2 (34.7%);Acute Tox. 3 (65.3%);Acute Tox. 1 (34.7%);Acute Tox. 3 (41.6%);Skin Irrit. 2 (41.6%);Skin Sens. 1 (41.6%);Eye Irrit. 2 (76.2%);Acute Tox. 2 (26.7%);Acute Tox. 3 (38.6%);STOT SE 3 (23.8%);Repr. 1B (34.7%);STOT SE 1 (34.7%);STOT RE 1 (34.7%);Aquatic Acute 1 (23.8%);Aquatic Chronic 1 (58.4%)

Acute toxicity - category 3

毒性情報

Treatment · 1 件

Following oral exposure, the treatment is symptomatic and supportive and includes monitoring for the development of hypersensitivity reactions with respiratory distress. Provide adequate airway management when needed. Gastric decontamination is usually not required unless the pyrethrin product is combined with a hydrocarbon. Following inhalation exposure, move patient to fresh air. monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. If the contamination occurs through dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. Vitamin E topical application is highly effective in relieving parenthesis. (T36)

Health Effects · 1 件

At high doses, signs of poisoning attributable to flumethrin include profuse salivation and pulmonary edema, clonic seizures, opisthotonos (i.e., the spine is bent forward such that a supine body rests on its head and heels), coma, and death. At lower doses, commonly observed effects include paresthesia and erythema. (L863)

Exposure RoutesInhalation (L857) ; oral (L857) ; dermal (L857) ; eye contact (L857).
Toxicity Summary · 1 件

Pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to the membrane lipid phase in the immediate vicinity of the sodium channel, thus modifying the channel kinetics. This blocks the closing of the sodium gates in the nerves, and thus prolongs the return of the membrane potential to its resting state. The repetitive (sensory, motor) neuronal discharge and a prolonged negative afterpotential produces effects quite similar to those produced by DDT, leading to hyperactivity of the nervous system which can result in paralysis and/or death. Other mechanisms of action of pyrethroids include antagonism of gamma-aminobutyric acid (GABA)-mediated inhibition, modulation of nicotinic cholinergic transmission, enhancement of noradrenaline release, and actions on calcium ions. (T18, L857)

Signs and Symptoms · 1 件

Following dermal exposure to flumethrin, feelings of numbness, itching, burning, stinging, tingling, or warmth may occur, that could last for a few hours. Dizziness, headache, nausea, muscle twitching, reduced energy, and changes in awareness can result from inhalation or ingestion of large amounts of flumethrin. Paralysis can occur after exposure. (L857)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Toxicity DataLD50: > 100 mg/kg (Oral, Rat) (L885) LD50: > 2000 mg/kg (Dermal, Rat) (L885) LD50: ~3000 mg/kg (Inhalation, Rat) (L885)

法規制情報

Regulatory InformationFlumethrin: HSNO Approval: HSR003432 Approved with controls

安全データ

wgk
3
ridadr
2902
hs_code
29269090
risk_code
23/24/25-36/38-43
消防法
危-4-3-III
hazard_code
T
safety_code
28-36/37-45
hazard_class
6.1(b)
packing_group
III
毒劇物取締法
III
Hazard Classifications
Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralEye Irrit. 2Skin Irrit. 2Skin Sens. 1
ストレージクラス
6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

使用Flumethrin is a synthetic pyrethroid insecticide used in the control of parasites, particularly ticks, on cattle, sheep, goats, horses, and dogs. Flumethrin is also used for control of mites in beehiv es.

サプライヤー100 社

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