D-(+)-メレチトース水和物

解説3F-α-D-glucopyranosyl sucrose．C18H32O16(504.44)．メレジトースともいう．三糖類の一種．シナノキTilia japonica Simk.，ポプラPopulus alba L.などの甘い樹液やハチミツに含まれる．"二水和物として結晶する．メレチトース, 融点153～154 ℃．[α]D＋88.2°(水)．非還元性であり，変旋光を示さない．希酸で穏やかに加水分解すると，D-グルコースと二糖ツラノースとを与え，細菌Proteus vulgarisから得られる酵素では，D-グルコースとスクロースとを生じる．森北出版「化学辞典（第2版）

使用d-(+)-Melezitose can be used to treat cancer, autoimmune diseases and infectious diseases.

純化方法D(+)-Melezitose crystallises from aqueous EtOH as the monohydrate and water as the dihydrate, and is then dried at 110o (anhydrous). It is also purified by dissolving in an equal volume of H2O, filtering into a crystallising dish and allowing to stand (loosely covered) for several weeks undisturbed at 20o. The crystals of clear prisms are wiped carefully and dried in air. They effloresce at once losing 3.35% of their weight, and after 3days in air the loss is for 1H2O from the dihydrate. Drying at 110o for 6hours in vacuo yields the anhydrous form which after 2days in air it absorbs H2O to give the monohydrate. The monohydrate is also obtained by dissolving it in an equal weight of H2O at 60o and adding 4 volumes of 95% EtOH and drying in air overnight. [Richtmeyer & Hudson J Org Chem 11 610 1946, Beilstein 17 III/IV 3815, 17/8 V 414.]