3-ドデシル-2-ヒドロキシ-1,4-ナフトキノン アセテート

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

A restricted entry interval of 12 hours. The standard WPS drift restriction of not applying in any way that will contact workers or other persons, either directly or through drift, and the statement that only protected workers may be in the area during application.

Not for use in or around residential sites. For use only in commercial greenhouses and shadehouses. Restrictions for Use on Ornamental Crops Grown in Greenhouses: Do not apply through any type of irrigation system. Do not contaminate water, food or feed by storage or disposal. DO NOT contaminate water when disposing of equipment wash waters.

Tolerances for combined residues of the insecticide acequinocyl, 2-(acetyloxy)-3-dodecyl-1,4-naphthalenedione, and its metabolite, 2-dodecyl-3-hydroxy-1,4-naphthoquinone, expressed as acequinocyl equivalents in or on the following commodities: almond 0.02 ppm; almond, hulls 2.0 ppm; apple, wet pomace 1.0 ppm; cattle, fat 0.02 ppm; cattle, liver 0.02 ppm; citrus, oil 30 ppm; fruit, citrus, group 10, 0.20 ppm; fruit, pome, group 11, 0.40 ppm; goat, fat 0.02 ppm; goat, liver 0.02 ppm; horse, fat 0.02 ppm; horse, liver 0.02 ppm; pistachio 0.02 ppm; sheep, fat 0.02 ppm; sheep, liver 0.02 ppm; and strawberry 0.40 ppm.

Approved respirator. Chemical-resistant gloves. Cover-alls over long-sleeved shirt and long pants. Protective eyewear and hat.

Use of Personal Protective Equipment (PPE) by applicators and other handlers, consisting of long-sleeved shirt and long pants, socks, shoes and chemical resistant gloves made of waterproof material.

LC50 Carp >96.5 mg/L/96 hr /Conditions of bioassay not specified in source examined/

LC50 Rainbow trout >33 mg/L/96 hr /Conditions of bioassay not specified in source examined/

LD50 Anas platyrhynchos (Mallard duck) oral 2000 mg/kg

LC50 Anas platyrhynchos (Mallard duck) dietary >5000 ppm (5 days)

For more Ecotoxicity Values (Complete) data for ACEQUINOCYL (9 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 56,000(SRC), determined from a log Kow of 6.2(2) and a regression-derived equation(3), indicates that acequinocyl is expected to be immobile in soil(SRC). Volatilization of acequinocyl from moist soil surfaces is expected to be slow(SRC) given an estimated Henry's Law constant of 9.7X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 1.27X10-8 mm Hg(2), and water solubility, 6.69X10-3 mg/L(2); adsorption to soil is expected to attenuate volatilization. Acequinocyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Observed half-lives of acequinocyl in sandy loam and silt soils were less than 2 days(2), indicating that biodegradation may be an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 56,000(SRC), determined from a log Kow of 6.2(2) and a regression-derived equation(3), indicates that acequinocyl is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected to be slow(3) based upon an estimated Henry's Law constant of 9.7X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 1.27X10-8 mm Hg(2), and water solubility, 6.69X10-3 mg/L(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 50 days and 550 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 4,800 years if adsorption is considered(4). According to a classification scheme(5), an estimated BCF of 33,000(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). Acequinocyl is expected to undergo hydrolysis based on measured half-lives of 86 days at pH 4, 52 hours at pH 7, and 76 minutes at pH 9 (all at 25 °C)(7). The half-life for the aqueous photolysis of this substance was measured to be 6 days at pH 5(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acequinocyl, which has a vapor pressure of 1.27X10-8 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere.

The Koc of acequinocyl is estimated as 56,000(SRC), using a log Kow of 6.2(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that acequinocyl is expected to be immobile in soil.

Acequinocyl's production may result in its release to the environment through various waste streams; it's use as a greenhouse miticide for the treatment of ornamental plants grown in commercial greenhouses and shadehouses(1) will result in its direct release to the environment(SRC).

An estimated BCF of 33,000 was calculated for acequinocyl(SRC), using a log Kow of 6.2(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC), provided the compound is not altered physically or chemically once released into the environment.

The Henry's Law constant for acequinocyl is estimated as 9.7X10-7 atm-cu m/mole(SRC) derived from its vapor pressure, 1.27X10-8 mm Hg(1), and water solubility, 6.69X10-3 mg/L(1). This Henry's Law constant indicates that acequinocyl is expected to volatilize slowly from water surfaces(2). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 50 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 550 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 4,800 years if adsorption is considered(3). Acequinocyl's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Acequinocyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

/LABORATORY ANIMALS: Acute Exposure/ Very mild skin and eye irritant (rabbits). Not a skin sensitiser (guinea pigs).

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Acequinocyl technical (purity=96.5%) was admixed to the feed and fed to 10 F344/DuCrj (Fischer) rats per sex per dose at dose levels of 0 (basal diet only), 100, 400, 1600, or 3200 ppm (0, 7.57, 30.4, 120, 253 mg/kg/day, respectively for males and 0, 8.27, 32.2, 129, 286 mg/kg/day, respectively for females) for 13 consecutive weeks. All animals at 3200 ppm died during the first 3 weeks of the study; no other mortalities occurred. Treatment-related reddish urine was observed in both sexes at 1600 ppm from Week 2 through Week 13. Hematology revealed a treatment-related increase in mean white blood cells and platelets in males at 1600 ppm with a treatment-related increase in mean prothrombin time and activated partial thromboplastin time in both males and females at 1600 ppm. Urinalysis revealed treatment-related red-brown urine in all animals of both sexes at 1600 which is consistent with the increased number of animals with bilirubin in their urine. Treatment-related yellow-brown urine in all animals of both sexes at 400 ppm suggesting the presence of the metabolite of the test material. Macroscopic examination on the surviving animals revealed an enlarged eye in 2 females at 1600 ppm. Microscopic examination on the surviving animals revealed no treatment related abnormalities. Macroscopic and microscopic examinations of the mortalities (including animals in moribund condition) revealed hemorrhaging of muscle and other organs and wasting of the whole body at 1600 and 3200 ppm dose levels. Possible adverse effect: inhibition of the coagulation system. /Tecnical product/

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Acequinocyl technical (purity = 97.1%) was made into a paste with 1% methylcellulose (w/v) and applied to the clipped dorsal skin of 10 Crl:(IGS)CD BR rats per sex per dose at dose levels of 0 (vehicle only), 40, 200, or 1000 mg/kg/day (plus an additional 10 animals per sex per dose at 0 and 1000 mg/kg/day to assess recovery for 2 weeks) for 6 hours per day 7 days a week for at least 28 days using a semi-occlusive dressing. No treatment related mortalities occurred. Red staining on the back of all animals at 40, 200, and 1000 mg/kg/day was observed in the morning only, from Day 2 through Day 13; the number of animals exhibiting this sign decreased in a dose-related manner after Day 13. The biological significance of this sign is unknown at this time. Hematological investigations revealed treatment-related increases in mean prothrombin time (in males only), activated partial thromboplastin time (in males and females), and fibrinogen (in males only) levels at 1000 mg/kg/day. Macroscopic and microscopic examinations revealed no treatment-related abnormalities. No adverse effects. NOEL (M/F, systemic) = 200 mg/kg/day based on blood clotting parameters. NOEL (M/F, skin) = 1000 mg/kg/day based on no treatment-related effects at the highest dose tested. /Tecnical product/

Acequinocyl is expected to undergo hydrolysis based on measured half-lives of 86 days at pH 4, 52 hours at pH 7, and 76 minutes at pH 9 (all at 25 °C)(1). The half-life for the aqueous photolysis of this substance was measured to be 6 days at pH 5(1).

Occupational exposure to acequinocyl may occur through inhalation and dermal contact with this compound at workplaces where acequinocyl is produced or used. The general population may be exposed to acequinocyl via dermal contact with ornamental plants that have been treated with this substance. (SRC)

Tolerances for combined residues of the insecticide acequinocyl, 2-(acetyloxy)-3-dodecyl-1,4-naphthalenedione, and its metabolite, 2-dodecyl-3-hydroxy-1,4-naphthoquinone, expressed as acequinocyl equivalents in or on the following commodities: almond; almond, hulls; apple, wet pomace; cattle, fat; cattle, liver; citrus, oil; fruit, citrus, group 10; fruit, pome, group 11; goat, fat; goat, liver; horse, fat; horse, liver; pistachio; sheep, fat; sheep, liver; and strawberry.

Used as an acaricide and insecticide; [HSDB] Registered for ornamental plants grown in greenhouses and shadehouses to control mites; [Reference #1]

Farming (Pesticides) [Category: Industry]

For acequinocyl (USEPA/OPP Pesticide Code: 006329) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Acaracide

Insecticide; controls Aculops,Panonychus, Polyphagatarsonemeus, and Tetranychus in apple, cherry, citrus, melon, pear, peach, cucumber, ornamentals, and vegetables.

Trade name: Piton

Kanemite

Suspension concentrate

Acequinocyl Technical is a powder composed of 96.8% Acequinocyl. This product is intended solely for manufacturing end-use products. Shuttle 15 SC Miticide is formulated as a flowable concentrate containing 1.25 pounds (lbs) of acequinocyl per gallon of product.

Acaricides

Environmental transformation -> Pesticides (parent, predecessor)