(3β,6β,14R)-グラヤノトキサン-3,5,6,10,14,16-ヘキサオール14-アセタート

説明Fructus Rhododendri (ba li ma) is the dried fruit of Rhododendron molle (Bl.) G. Don (yánɡ zhí zhú), mainly distributed in the Jiangsu, Hubei, and Jiangxi Provinces of China .“Compendium of Materia Medica” recorded that Rhododendron molle (Bl.) G. Don (yánɡ zhí zhú) can be used to treat waist pain, arm pain, and poisoning. It is effective at lowering blood pressure and slowing the heart rate, but a large dosage can cause death . Rhomotoxin’s formulations include injection and tablet. Side effects include a burning sensation, numbness, dizziness, dry mouth, nausea, vomiting, vertigo, chest tightness, slow heartbeat, and low blood pressure. In addition, pregnant women should use it with caution.

来歴Because rhomotoxin can slow down heart rhythm and blood pressure, Deng Dao ji et al. from the First Affiliated Hospital of Wuhan Medical College researched Fructus Rhododendri in the early 1970s. They extracted the crystallization from fruits and obtained preliminary results by animal testing and clinical application .Rhomotoxin is a white needle crystal that is extracted from the dried fruit of Rhododendron molle (Bl.) G. Don (yánɡ zhí zhú). Its biological activity is closely related to three-dimensional specificity and hydrophobicity. 5β-hydroxyl, 6β- hydroxyl, and, especially, the 2,3-epoxy groups can affect its biological activity .Rhomotoxin was acetylated to obtain monoacetate (Japanese Rhododendron II). The melting points of rhomotoxin and Japanese Rhododendron III are identical (284–286 °C). IR and Rf of silica gel thin layer chromatography are identical. Therefore, rhomotoxin is Japanese Rhododendron III .