基本情報
- CAS
339-44-6- 標準SMILES
COCCOc1cnc(NS(=O)(=O)c2ccccc2)nc1- InChIKey
QFWPJPIVLCBXFJ-UHFFFAOYSA-N- 分子式
- C13H15N3O4S
- 平均分子量
- 309.34 g/mol
- 単同位体質量
- 309.07832714
概要
Glymidine is a sulfonamide that is N-(pyrimidin-2-yl)benzenesulfonamide which is substituted at position 5 of the pyrimidine ring by a 2-methoxyethoxy group. It is a hypoglycemic drug used for the treatment of diabetes mellitus. It has a role as a hypoglycemic agent. It is a sulfonamide, a member of pyrimidines and a diether. It is a conjugate acid of a glymidine(1-).
名称と識別子
- 優先名称
- Glymidine
- IUPAC
- N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
- 現地名
- N-[5-(2-メトキシエトキシ)-2-ピリミジニル]ベンゼンスルホンアミド
- 英語名
- N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
- 分子式
- C13H15N3O4S
- 分子量
- 309.3409
名称と別名
GLYMIDINEGlycodiazineGlidiazine339-44-6GlymidinumN-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamideN-(5-(2-Methoxyethoxy)pyrimidin-2-yl)benzenesulfonamide4C5I4BQZ8FBenzenesulfonamide, N-(5-(2-methoxyethoxy)-2-pyrimidinyl)-DTXSID1023108CHEBI:146188Benzenesulfonamide, N-[5-(2-methoxyethoxy)-2-pyrimidinyl]-
名称をさらに表示
N-[5-(2-メトキシエトキシ)ピリミジン-2-イル]ベンゼンスルホンアミドN-[5-(2-メトキシエトキシ)-2-ピリミジニル]ベンゼンスルホンアミドN-[5-(2-methoxyethoxy)-2-pyrimidinyl]benzenesulphonamide
RefChem:144030DTXCID703108206-426-5GlycodiazinN-(5-(2-Methoxyethoxy)-2-pyrimidinyl)benzenesulfonamideN-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamideN-(5-(2-Methoxyethoxy)-2-pyrimidinyl)benzenesulphonamideGlycodiazin [German]
データベース識別子
- CAS
339-44-6- PubChem CID
- 9565
- DTXSID
DTXSID1023108
物性
構造計算による物性
- XLogP
- 0.9
- 極性表面積
- 98.8 Ų
- 水素結合供与体数
- 1
- 水素結合受容体数
- 7
- 回転可能結合数
- 7
- 重原子数
- 21
- 形式電荷
- 0
- 複雑度
- 385
実験および物理化学的性質
DrugsPharmaceuticals -> Listed in ZINC15
Solubility1.24e-01 g/L
Melting Point220-223
Physical DescriptionSolid
物理化学的性質
- 融点
- 152 · 152-154°
- 貯蔵温度
- Refrigerator
- 溶解性
- クロロホルム（微量）、酢酸エチル（微量）
- 外見
- 個体
- 色
- ライトベージュ
化学と産業
薬理情報
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Protein Binding90% bound to plasma proteins.
PharmacodynamicsGlycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin.
Mechanism of Action
The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
Biological Half-Life4 hours.
Absorption, Distribution and ExcretionRapidly and completely absorbed following oral administration.
Cellular LocationsMembrane
応用分野
使用Glymidine is used in biological activities to predict human intestinal absorption in drug discovery.
上流・下流製品情報
上流原料
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