プロカルバジン塩酸塩

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Danger

H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

SYMPTOMS: Symptoms of exposure to this compound may include nausea, vomiting, leukopenia and thrombocytopenia. Other symptoms include somnolence, lethargy, hallucinations, confusion, agitation, cerebellar ataxia, paresthesias, myalgia, decrease of deep tendon reflexes, hypotension and allergic skin reactions. Exposure may cause arthralgia, fever, weakness, dermatitis, coma, alopecia and convulsions. It may also cause anorexia, stomatitis, diarrhea, drowsiness and depression. Other symptoms include bone marrow depression, hemolysis, bleeding tendencies, psychoses, dizziness, peripheral neuropathy, tremors, flu-like syndrome, pulmonary reactions, tachycardia, ocular defects such as blurred vision and papilledema, impaired liver function, shortness of breath, pneumonitis and productive cough. It may also cause reversible depression of peripheral leukocyte and platelet counts, optic neuroretinitis and pulmonary eosinophilia. Other symptoms include hemolytic anemia, dry mouth, dysphagia, constipation, fatigue pruritus, herpes, hyperpigmentation, flushing, intercurrent infections, pleura effusion, edema, jaundice, headache, apprehension, nervousness, inability to focus, insomnia, pyrexia, hypersensitivity reactions, hemorrhage, pancytopenia eosinophilia, petechiae, purpura, epistaxis, hemoptysis, hematemesis, melena, nystagmus, urticaria, hearing loss, diaphoresis, chills, hoarseness, slurred speech, enteritis, nightmares, falling, unsteadiness, abdominal pain, syncope, retinal hemorrhage, photophobia, diplopia, hematuria, urinary frequency, nocturia, foot drop and fetal harm. Exposure to this compound and alcohol can cause flushing of the head and neck, palpitations, sweating, hypotension and dyspnea.

PROCARBAZINE HYDROCHLORIDE

Alkylating Drug [EPC]; Alkylating Activity [MoA]