ACTH (4-7), Pro-Gly-Pro-
基本情報
- CAS
80714-61-0- 標準SMILES
CSCC[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)O- InChIKey
AFEHBIGDWIGTEH-AQRCPPRCSA-N- 分子式
- C37H51N9O10S
- 平均分子量
- 813.9 g/mol
- 単同位体質量
- 813.34796003
名称と識別子
- 優先名称
- ACTH (4-7), Pro-Gly-Pro-
- IUPAC
- (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
- 英語名
- Semax
- 分子式
- C37H51N9O10S
- 分子量
- 813.92
名称と別名
Semax80714-61-0ACTH (4-7), Pro-Gly-Pro-I5FAL2585HACTH (4-7), prolyl-glycyl-proline-Pro-gly-pro-acth (4-7)RefChem:56007MEHFPGPMet-Glu-His-Phe-Pro-Gly-ProL-Methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acidSemax?
名称をさらに表示
SemaxAcetateSemax Acetatlemod soluSemax 10mgSemax -20mgprednol [inj.]Peptides Semax
H-Met-Glu-His-Phe-Pro-Gly-Pro-OHL-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-prolineUNII-I5FAL2585Horb1705158SCHEMBL7200319C37H51N9O10SGLXC-25922HY-P1146
物性
構造計算による物性
- XLogP
- -2.8
- 極性表面積
- 312 Ų
- 水素結合供与体数
- 8
- 水素結合受容体数
- 13
- 回転可能結合数
- 21
- 重原子数
- 57
- 形式電荷
- 0
- 複雑度
- 1,450
物理化学的性質
- 沸点
- 1335.2 · 1335.2±65.0 °C(Predicted)
- 比重(密度)
- 1.391 · 1.391±0.06 g/cm3(Predicted)
- 貯蔵温度
- -20 °C · -20°C
- 溶解性
- 2 O: · H2O: >2mg/mL
- 外見
- 粉
- 酸解離定数(Pka)
- 3.43 · 3.43±0.20(Predicted)
- 色
- 白から黄褐色
- 水溶解度
- 2 mg/ml · Soluble to 2 mg/ml in water
- InChIKey
- AFEHBIGDWIGTEH-YNWVLKOQNA-N
- SMILES
- N1(CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCSC)CC1N=CNC=1)CC1=CC=CC=C1 |&1:4,15,21,25,29,38,r|
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
安全データ
- wgk
- 3
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
MeSH Pharmacological Classification
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms.
応用分野
説明Semax is a synthetic analogue of the adrenocorticotropic hormone, a hormone responsible for the production of cortisol which in turn regulates glucose and lipid metabolism and helps to maintain blood pressure. In the hippocampus, Semax rapidly elevates the levels of brain-derived neurotrophic factor (BDNF), a protein important in encouraging growth and differentiation of new neurons and synapses. BDNF is active in the hippocampus, cortex, and forebrain and is important for memory, coordination, concentration, and learning. Semax also works to activate the dopaminergic and serotonergic systems to help prime the brain for action and to induce a controlled state of mental stress.
使用Semax has been prescribed for anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal and even chronic diseases such as ALS, Parkinson’s Disease, and Alzheimer’s. Semax has been known to be used as an Adderall alternative.
上流・下流製品情報
上流原料
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