基本情報
- CAS
108560-70-9- 標準SMILES
Cc1occc(=O)c1[O-].Cc1occc(=O)c1[O-].Cc1occc(=O)c1[O-].[Ga+3]- InChIKey
ASYYOZSDALANRF-UHFFFAOYSA-K- 分子式
- C18H15GaO9
- 平均分子量
- 445 g/mol
- 単同位体質量
- 443.99718
概要
Gallium maltolate is Titan’s novel oral agent in development for the potential treatment of chronic bacterial infections, bone disease and cancer.
名称と識別子
- 優先名称
- Gallium Maltolate
- IUPAC
- gallium tris(2-methyl-4-oxopyran-3-olate)
- 英語名
- GalliuM Maltolate
- 分子式
- C18H15GaO9
- 分子量
- 445.03
名称と別名
gallium maltolate108560-70-9tris(maltolato)gallium(III)17LEI49C2Gtris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium(III)4H-pyran-4-one, 3-hydroxy-2-methyl-, gallium salt (3:1)RefChem:142192DTXCID201527756DTXSID001045825gallium tris(2-methyl-4-oxo-4H-pyran-3-olate)gallium;2-methyl-4-oxopyran-3-olateC18H15GaO9
名称をさらに表示
GallixaGallium maltolate (Gallixa)GALLIUM MALTOLATE(108560-70-9)Gallium maltolate, 10 mM in DMSOTris[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]galliuMTris[3-(hydroxy-kappaO)-2-Methyl-4H-pyran-4-onato-kappaO4]galliuM
gallium;2-methyl-4-oxidanylidene-pyran-3-olate3-bis[(2-methyl-4-oxopyran-3-yl)oxy]gallanyloxy-2-methylpyran-4-oneGallium maltolate [WHO-DD]SCHEMBL29366290MFCD27976780DB05420DA-53477GALLIUM, TRIS(3-(HYDROXY-.KAPPA.O)-2-METHYL-4H-PYRAN-4-ONATO-.KAPPA.O4)-, (OC-6-21)-
データベース識別子
- CAS
108560-70-9
物性
構造計算による物性
- 極性表面積
- 148 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 9
- 回転可能結合数
- 0
- 重原子数
- 28
- 形式電荷
- 0
- 複雑度
- 200
物理化学的性質
- 外見
- Solid
- 色
- Off-white to light yellow
- 化粧品成分の機能
- スキンコンディショニング
- InChI
- InChI=1S/3C6H4O5.Ga/c3*7-3-1-2-11-5(4(3)8)6(9)10;/h3*1-2,8H,(H,9,10);/q;;;+3/p-3
- InChIKey
- LRPKBZSTANNRLK-UHFFFAOYSA-K
- SMILES
- [Ga+3].O1C(C([O-])=O)=C(O)C(=O)C=C1.O1C(C([O-])=O)=C(O)C(=O)C=C1.O1C(C([O-])=O)=C(O)C(=O)C=C1
化学と産業
薬理情報
Mechanism of Action
Gallium maltolate is a novel orally active formulation of gallium, a semi-metallic element that is a potent inhibitor of ribonucleotide reductase, an enzyme that promotes tumor growth.Gallium is also known to concentrate in malignant tumors and sites of infection, and appears to favorably impact calcium deposition, making bones more resistant to degradation caused by cancer metastasis. Titan's novel product, gallium maltolate, may significantly expand the therapeutic potential of gallium by providing the advantages of enhanced bioavailablity, a potentially improved therapeutic profile and ease of administration.
応用分野
説明Gallium maltolate (GaM) is a new orally administered compound that has the potential to fundamentally improve the lives of many of these patients by providing effective treatment without serious side effects. GaM is being developed as an orally active formulation of gallium, a drug already approved by the FDA in intravenous form (gallium nitrate for injection). Clinical and preclinical studies have repeatedly shown gallium to have efficacy against cancer, inflammatory disorders, infectious disease, and bone loss.
サプライヤー24 社
合肥曼奇诺生物医药技术有限公司19719236623 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
北京颖诺凯胜科技有限公司010-56541685 13070143590 · [email protected]
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