基本情報
- CAS
476322-70-0- 標準SMILES
COc1ccc(CN2CCN(c3ccc(Br)c(OC)n3)CC2)cc1OC- InChIKey
VAKYVNYLCIABRV-UHFFFAOYSA-N- 分子式
- C19H24BrN3O3
- 平均分子量
- 422.3 g/mol
- 単同位体質量
- 421.1001
概要
NGD-4715 is an investigational compound developed for the treatment of Obesity. NGD-4715 functions as a melanin-concentrating hormone receptor 1 antagonist.
名称と識別子
- 優先名称
- Ngd-4715
- IUPAC
- 1-(5-bromo-6-methoxy-2-pyridinyl)-4-[(3,4-dimethoxyphenyl)methyl]piperazine
- 英語名
- NGD-4715
- 分子式
- C19H24BrN3O3
- 分子量
- 422.32
名称と別名
NGD-4715476322-70-0DTXSID10432090RefChem:165626DTXCID003829191-(5-bromo-6-methoxypyridin-2-yl)-4-(3,4-dimethoxybenzyl)piperazineNGD 47151-(5-bromo-6-methoxypyridin-2-yl)-4-[(3,4-dimethoxyphenyl)methyl]piperazineorb1706913SCHEMBL4712990SCHEMBL29858194VAKYVNYLCIABRV-UHFFFAOYSA-N
名称をさらに表示
NGD4715,NGD 4715Piperazine, 1-(5-bromo-6-methoxy-2-pyridinyl)-4-[(3,4-dimethoxyphenyl)methyl]-
BUA32270AKOS040742285DA-76156HY-100318CS-0018469T16293Q6953947
データベース識別子
- CAS
476322-70-0- PubChem CID
- 9866893
- DTXSID
DTXSID10432090
物性
構造計算による物性
- XLogP
- 3.6
- 極性表面積
- 47.1 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 6
- 回転可能結合数
- 6
- 重原子数
- 26
- 形式電荷
- 0
- 複雑度
- 423
物理化学的性質
- 貯蔵温度
- -20 °C · Store at -20°C
- 溶解性
- Soluble in DMSO
化学と産業
薬理情報
Mechanism of Action
NGD-4715 works as a small molecule antagonist at the melanin concentrating hormone receptor-1 (MCHR1). Neurogen’s obesity program has focused on blocking the melanin concentrating hormone receptor-1 (MCH1). Reported studies in rodents support MCH being an important mediator of caloric intake. Deletion of MCH or the MCH1 receptor gene resulted in lean animals, while over-production of MCH caused increased weight gain. Neurogen’s studies indicated that selectively blocking MCH1 was sufficient to achieve a significant reduction in food intake in a higher animal species.
応用分野
使用NGD 4715, is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist .
サプライヤー8 社
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
上海与昂生物科技有限公司021-58111628 15800915896 · [email protected]
上海凯裕医药科技有限公司17317130613 · [email protected]
天津凯芾医药科技有限公司18081075745 · [email protected]
济南睿思医药技术有限公司0531-0531-69900633 19963472814 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
济南九黎生物科技有限公司15865264761 · [email protected]
関連反応
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化合物ノート
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