QX314

QX-314 bromide

HCID 9884487
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基本情報

CAS
24003-58-5
標準SMILES
CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C.[Br-]
InChIKey
DLHMKHREUTXMCH-UHFFFAOYSA-N
分子式
C16H27BrN2O
平均分子量
343.3 g/mol
単同位体質量
342.13067558

概要

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名称と識別子

優先名称
QX-314 bromide
IUPAC
[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium bromide
現地名
QX314
英語名
N-ETHYLLIDOCAINE BROMIDE
分子式
C16H27BrN2O
分子量
343.31

名称と別名

24003-58-5N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromideQX-314 BROMIDE3OYF1S84ENDTXSID001018052Ethanaminium, 2-((2,6-dimethylphenyl)amino)-N,N,N-triethyl-2-oxo-, bromide (1:1)Ethanaminium, 2-[(2,6-dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-, bromide (1:1)RefChem:178403DTXCID401476274Lidocaine N-ethyl bromideQX 314 bromideQX-314 (bromide)
名称をさらに表示
QX314N-ETHYLLIDOCAINE BROMIDEQX 314 bromide,QX314 bromide[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE
Lidocaine N-ethyl bromide quaternary salt[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;bromideUNII-3OYF1S84ENMFCD00083182QX-314 BrSR-01000075323QX314 BromideMLS000859919

データベース識別子

CAS
24003-58-5
PubChem CID
9884487
DTXSID
DTXSID001018052
ChEMBL
CHEMBL1255750
UNII
3OYF1S84EN

物性

構造計算による物性

極性表面積
29.1 Ų
水素結合供与体数
1
水素結合受容体数
2
回転可能結合数
6
重原子数
20

実験および物理化学的性質

Solubility>51.5 [ug/mL] (The mean of the results at pH 7.4)

物理化学的性質

融点
214 · 214-215 °C
貯蔵温度
Desiccate at RT
溶解性
10.5 mg/mL · insoluble in EtOH; ≥10.5 mg/mL in H2O; ≥25.55 mg/mL in DMSO
外見
crystalline solid
色
White
水溶解度
100 mM · Soluble to 100 mM in water

化学と産業

薬理情報

MeSH Pharmacological Classification · 1 件

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

応用分野

使用QX-314 bromide is a derivative of Lidocaine. It is a local anesthetic.

上流・下流製品情報

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