2-[[[4-(4-フルオロフェノキシ)フェニル]スルホニル]アミノ]-N-ヒドロキシ-2-メチルプロパンアミド

用途広範囲の MMP 阻害剤です（IC50=0.7 nM（MMP-2），0.9 nM（MMP-13），13 nM（MMP-9）， 16 nM（MMP-3），1170 nM（MMP-1））。

用途広範囲の MMP 阻害剤です（IC50=0.7 nmol/l（MMP-2），0.9 nmol/l（MMP-13），13 nmol/l （MMP-9），16 nmol/l（MMP-3），1,170 nmol/l（MMP-1））。

説明CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.

使用A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.