HCID 18403070、化合物 → HCID 9903422、化合物

HRID 1003169ノート

反応式

HRID 1003169 の反応式
[CH2:1]([P:5]([CH2:8][CH:9]([C:22]([O:24]CC1C=CC=CC=1)=[O:23])[CH2:10][CH2:11][C:12]([O:14]CC1C=CC=CC=1)=[O:13])(=[O:7])[OH:6])[CH2:2][CH2:3][CH3:4]>O>[CH2:1]([P:5]([CH2:8][CH:9]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:22]([OH:24])=[O:23])([OH:7])=[O:6])[CH2:2][CH2:3][CH3:4]

参加物

3

反応物 1

HCID 18403070HCID 18403070、化合物

生成物 1

HCID 9903422HCID 9903422、化合物収率 43.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Butyl[2,4-di(benzyloxycarbonyl)butyl]phosphinic acid (2.9 g, 6.5 mmol) in 30 mL of water containing 0.32 g 10% Pd/C was hydrogenated on a Parr hydrogenator at 40 psi for 4.5 hours. The mixture was filtered through a pad of Celite and evaporated under high vacuum to give 2-[(butylhydroxyphosphinyl)methyl]pentanedioic acid (4, R=n-butyl) (0.75 g, 43%) as a clear and colorless viscous oil. 1H NMR (D2O): 2.4 ppm (m, 1H), 2.1 ppm (t, 2H), 1.9 ppm (m, 1H), 1.6 ppm (m, 3H), 1.4 ppm (m, 2H), 1.1 ppm (m, 4H), 0.6 ppm (t, 3H) Elemental Analysis Calculated C10H19O6P. 0.5 H2O: C 43.64, H 7.32: Found C 43.25, H 7.12

後処理

  1. filtrationThe mixture was filtered through a pad of Celite
  2. customevaporated under high vacuum

出典と根拠

ORDレコード
ord-54eb03ef77d8497cb3eb9d78dc3a0dd6
出典データセット
uspto-grants-2000_04
特許番号
US06046180

反応ノート

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