Hydrochloric Acid → 2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide hydrochloride

HRID 1003288ノート

反応式

HRID 1003288 の反応式
[OH:1][C@H:2]([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[CH2:3][NH:4][C@H:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:15][CH2:16][C:17]([N:19]([CH3:21])[CH3:20])=[O:18])=[CH:10][CH:11]=2)[CH2:6]1.[ClH:29]>C(O)C>[ClH:29].[OH:1][C@H:2]([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[CH2:3][NH:4][C@H:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:15][CH2:16][C:17]([N:19]([CH3:20])[CH3:21])=[O:18])=[CH:10][CH:11]=2)[CH2:6]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 98214472-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide

生成物 1

HCID 104548412-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-[(2S)-2-[[(2R)-2-Hydroxy-2-(4-hydroxy-phenyl)ethyl]-amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide (210 mg) was suspended in ethanol (10.5 ml), and 1N hydrochloric acid (546 μl) was added to the suspension and the mixture was dissolved by heating. After cooling, collection by filtration of the precipitated crystals gave 2-[(2S)-2-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-1,2,3,4-tetrahydronaphthalen-7-yloxy]-N,N-dimethylacetamide hydrochloride (100 mg) having a melting point of 165-168° C.

後処理

  1. dissolutionthe mixture was dissolved
  2. temperatureby heating
  3. temperatureAfter cooling
  4. customcollection
  5. filtrationby filtration of the precipitated crystals

出典と根拠

ORDレコード
ord-25737600d3714beab167194fc2637fbe
出典データセット
uspto-grants-2000_04
特許番号
US06046192

反応ノート

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