Hydrochloric Acid → 12-Iodododecylamine hydrochloride

HRID 1003314ノート

反応式

HRID 1003314 の反応式
[I:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[I:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 1879643112-(Boc-amino)-1-dodecyl iodine

生成物 1

HCID 1879643312-Iodododecylamine hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 0.33 g of tert-butyl N-(12-iodododecyl)carbamate in 25 ml of ethyl acetate was added 2.6 ml of hydrochloric acid and the mixture was stirred for 0.5 hour. The reaction solution was distilled off under reduced pressure. The residue was dissolved in chloroform, washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Crystallization from ethyl acetate and hexane afforded 0.17 g of the title compound.

後処理

  1. distillationThe reaction solution was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure
  6. customCrystallization from ethyl acetate and hexane

出典と根拠

ORDレコード
ord-9d8086cb726c47e79befbdda465bcca0
出典データセット
uspto-grants-2000_04
特許番号
US06046201

反応ノート

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