化工社化工社 化学情報印刷レポート · 研究参考用
4-Ethoxybenzaldehyde → alpha-(4-Ethoxyphenyl)-N-tert-octylnitrone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Ethoxybenzaldehyde | HCID 24834 | — |
| 反応物 | tert-Octylamine | HCID 61017 | — |
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | HCID 18433750 | HCID 18433750 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | alpha-(4-Ethoxyphenyl)-N-tert-octylnitrone | HCID 86587909 | — |
反応手順
The title compound was prepared by oxidation of N-(4-ethoxyphenyl)-N-tert-octylamine with m-chloroperoxybenzoic acid in methylene chloride. The amine was synthesized via NaBH4 reduction from the corresponding imine which was acquired by condensation of 4-ethoxybenzaldehyde and tert-octylamine in methanol. The title compound was isolated in 65.0% overall yield as white crystals, m.p. 100.8° C. (Rf =0.33 on silica gel plate using hexanes:EtOAc, 7:3, v/v, as an eluant).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06046232 |
| 出典データセット | uspto-grants-2000_04 |
| ORD ID | ord-c68146c80b7f4da5872fd5316ca2ac09 |
| 出典メモ | uspto-grants-2000_04 |