4-Bromobenzohydrazide → 2-(4-Bromophenyl)-5-methyl-1,3,4-oxadiazole

HRID 1003704

反応式

HRID 1003704 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.[C:12](OCC)(OCC)(OCC)[CH3:13]>>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]2[O:7][C:12]([CH3:13])=[N:9][N:8]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 222194-BromobenzohydrazideHCID 66221Triethyl orthoacetate

生成物 1

HCID 5406932-(4-Bromophenyl)-5-methyl-1,3,4-oxadiazole収率 87%

実験手順

A stirred suspension of 4-bromobenzoic hydrazide (4.0 g, 18.6 mmol) in triethyl orthoacetate (15 ml) was heated under reflux for 24 h. The reaction mixture was cooled and the precipitate filtered, washed with 60-80° C. petroleum ether (20 ml) and dried to give the title compound as a yellow solid (3.86 g, 87%).

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 24 h
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe precipitate filtered
  5. washwashed with 60-80° C. petroleum ether (20 ml)
  6. customdried

出典と根拠

ORDレコード
ord-77deb1aae56a4c75b9cfb0feaa4e0936
出典データセット
uspto-grants-2000_04
特許番号
US06046210

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