Fludarabine Phosphate → Fludarabine phosphate magnesium salt

HRID 1003722

反応式

HRID 1003722 の反応式
[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][O:16][P:17]([OH:20])([OH:19])=[O:18])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[O-2].[Mg+2:26]>O>[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[Mg+2:26].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[Mg+2:26].[Mg+2:26]

参加物

4

反応物 2

HCID 30751Fludarabine PhosphateHCID 6850729Magnesium monoxide

生成物 1

HCID 86755286Fludarabine phosphate magnesium salt収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

10.0 g of fludarabine phosphate at a purity of 97.5% is suspended in 100 ml of water within about 5 minutes, and magnesium oxide is added to this solution. The mixture is stirred for one more hour at room temperature and then filtered. The clear solution is poured into 200 ml of acetone, stirred for 1 more hour, and the crystallizate is separated by filtration. 10.0 g (95% of theory) of the fludarabine-phosphate magnesium salt is obtained.

後処理

  1. filtrationfiltered
  2. additionThe clear solution is poured into 200 ml of acetone
  3. stirringstirred for 1 more hour
  4. customthe crystallizate is separated by filtration

出典と根拠

ORDレコード
ord-51090bcb15194d508c3c7e0872bdadfc
出典データセット
uspto-grants-2000_04
特許番号
US06046322

関連ノート

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