Methyl 5-(1,8-naphthyridin-2-yl)pentanoate → Methyl 5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoate
反応式
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[N:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1.[H][H]>CCO.[Pd].[C]>[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:17]=[CH:16][C:15]2[CH2:14][CH2:13][CH2:12][NH:11][C:10]=2[N:9]=1参加物
5
実験手順
A mixture of 1-4 (630 mg, 2.58 mmol) and 10% Pd/carbon (95 mg) in EtOH (25 mL) was stirred under a balloon of hydrogen for 72 h. Following filtration and evaporative removal of the solvent, the residue was chromatographed (silica gel, 70% ethyl acetate/hexanes) to give 1-5 as a colorless oil.
後処理
- filtrationfiltration
- customremoval of the solvent
- customthe residue was chromatographed (silica gel, 70% ethyl acetate/hexanes)
出典と根拠
- ORDレコード
- ord-0bcd7e5842a041228084473322e20461
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06048861
反応ノート
読み込み中…