関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Diphenylpropylphosphine | HCID 82100 | — |
| 反応物 | Trioctylsilane, 95% | HCID 87780 | — |
| 反応物 | Benzofuran-6-YL trifluoromethanesulfonate | HCID 11357589 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Benzofuran-6-carbaldehyde | HCID 14354086 | — |
反応手順
A solution of triflate 20-3 (0.798 g, 3.0 mmol), Pd(OAc)2 (13.5 mg, 0.060 mmol), and diphenylphosphinopropane (24 mg, 0.060 mmol) in DMF (15 mL) was heated to 70° C. with a gentle flow of CO (g) passing through it. Triethylamine (1.66 mL, 12 mmol) was added followed by trioctylsilane (2.70 mL, 6.0 mmol). The solution was maintained at 70° C. for 2 h, and cooled to room temperature. The solution was diluted with water (10 mL). The mixture was extracted with Et2O (2×30 mL). The combined organic extracts were washed with brine (10 mL), dried over MgSO4, filtered and concentrated. The residue was purified by flash chromatography (5% acetone/hexanes) to give the desired aldehyde 20-4.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06048861 |
|---|
| 出典データセット | uspto-grants-2000_04 |
|---|
| ORD ID | ord-a514bf9b46dd4cb4b84a88899ab2f33b |
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| 出典メモ | uspto-grants-2000_04 |
|---|
