Methanol → Methyl (2-chlorophenyl)acetate
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]参加物
4
実験手順
A solution of 2-chlorophenylacetic acid (10.0 g) in methanol (100 ml) containing 1 drop of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was evaporated to half volume and partitioned between ethyl acetate (100 ml) and water (100 ml). The organic phase was dried over magnesium sulphate and evaporated to give the title compound (10.0 g) as a colourless oil.
後処理
- temperaturewas heated
- temperatureat reflux for 2 hours
- customThe reaction mixture was evaporated to half volume
- custompartitioned between ethyl acetate (100 ml) and water (100 ml)
- dry with materialThe organic phase was dried over magnesium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-9fca659e73f847a3a5eb5a0804ca6a53
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06048893
反応ノート
読み込み中…