Methanol → Methyl (2-chlorophenyl)acetate

HRID 1004306

反応式

HRID 1004306 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]

参加物

4

反応物 2

HCID 887MethanolHCID 17124o-Chlorophenylacetic acid

生成物 1

HCID 93683Methyl (2-chlorophenyl)acetate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

A solution of 2-chlorophenylacetic acid (10.0 g) in methanol (100 ml) containing 1 drop of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was evaporated to half volume and partitioned between ethyl acetate (100 ml) and water (100 ml). The organic phase was dried over magnesium sulphate and evaporated to give the title compound (10.0 g) as a colourless oil.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. customThe reaction mixture was evaporated to half volume
  4. custompartitioned between ethyl acetate (100 ml) and water (100 ml)
  5. dry with materialThe organic phase was dried over magnesium sulphate
  6. customevaporated

出典と根拠

ORDレコード
ord-9fca659e73f847a3a5eb5a0804ca6a53
出典データセット
uspto-grants-2000_04
特許番号
US06048893

関連ノート

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