Methanol → Methyl [2-(trifluoromethyl)phenyl]acetate

HRID 1004308ノート

反応式

HRID 1004308 の反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=[O:11].[CH3:15]O>S(=O)(=O)(O)O>[F:1][C:2]([F:13])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([O:12][CH3:15])=[O:11]

参加物

4

反応物 2

HCID 887MethanolHCID 594597(2-(trifluoromethyl)phenyl)acetic acid

生成物 1

HCID 23294844Methyl [2-(trifluoromethyl)phenyl]acetate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

A solution of 2-trifluoromethylphenylacetic acid (5.0 g) in methanol (30 ml) containing 5 drops of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was concentrated, diluted with ethyl acetate (100 ml), washed with 1N sodium hydroxide (25 ml) then with brine (25 ml), dried over magnesium sulphate and evaporated to give the title compound (5.04 g) as a colourless oil.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. concentrationThe reaction mixture was concentrated
  4. additiondiluted with ethyl acetate (100 ml)
  5. washwashed with 1N sodium hydroxide (25 ml)
  6. dry with materialwith brine (25 ml), dried over magnesium sulphate
  7. customevaporated

出典と根拠

ORDレコード
ord-e310ac7d8779480c96918d4b492204f8
出典データセット
uspto-grants-2000_04
特許番号
US06048893

反応ノート

読み込み中…