Hydrochloric Acid → N-[2-[(Aminothioxomethyl)hydrazono]-2-phenylethyl]acetamide
反応式
[NH2:1][NH:2][C:3]([NH2:5])=[S:4].O=[C:7]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:8][NH:9][C:10](=[O:12])[CH3:11].Cl.O>CO>[NH2:5][C:3]([NH:2][N:1]=[C:7]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:8][NH:9][C:10](=[O:12])[CH3:11])=[S:4]参加物
6
実験手順
Thiosemicarbazide (1.98 g, 20 mmol) was added to a solution of N-(2-oxo-2-phenyl-ethyl)-acetamide (3.84 g, 20 mmol, prepared in the previous step, in 70 ml of methanol plus 5.4 ml of 1N HCl plus 5.0 ml of water and the reaction stirred at room temperature overnight. The solid formed was collected by filtration and dried to give 3.9 g (78%) of the title compound as a white solid, mp 208-211° C.
後処理
- customThe solid formed
- filtrationwas collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-d3dc8dc7680d4ea2acf7c93c70220ce4
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06049006
反応ノート
読み込み中…