2-Amino-4-(3-methoxyphenyl)-1H-pyrrole-3-carbonitrile → HCID 18792871、化合物

HRID 1004605ノート

反応式

HRID 1004605 の反応式
[C:1]([C:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=2)=[CH:6][NH:5][C:4]=1[NH:16][CH:17]=[NH:18])#[N:2].NC1NC=C(C2C=CC=C(OC)C=2)C=1C#N>C(OCC)(OCC)OCC>[CH3:15][O:14][C:10]1[CH:9]=[C:8]([C:7]2[C:3]3[C:1]([NH2:2])=[N:18][CH:17]=[N:16][C:4]=3[NH:5][CH:6]=2)[CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 187929202-Amino-4-(3-methoxyphenyl)-1H-pyrrole-3-carbonitrileHCID 178489845HCID 178489845、化合物

生成物 1

HCID 18792871HCID 18792871、化合物

試薬・触媒・溶媒 1

HCID 31214Ethyl orthoformate溶媒

反応条件

温度
140 °C

実験手順

N-[3-Cyano-4-(3-methoxy-phenyl)-1H-pyrrol-2-yl]formamidine: 5.30 g of 2-amino4-(3-methoxy-phenyl)-1H-pyrrole-3-carbonitrile are dissolved in 50 ml of triethyl orthoformate, and the solution is stirred for 1 hour at 140° C. The triethyl orthoformate is removed under a high vacuum and the residue is dissolved in methanol saturated with ammonia. Stirring is carried out for 20 hours at room temperature, followed by filtration. The product is recrystallised from ethanol. M.p.: 188-190° C.

後処理

  1. customThe triethyl orthoformate is removed under a high vacuum
  2. dissolutionthe residue is dissolved in methanol saturated with ammonia
  3. stirringStirring
  4. waitis carried out for 20 hours at room temperature
  5. filtrationfollowed by filtration
  6. customThe product is recrystallised from ethanol

出典と根拠

ORDレコード
ord-85c73a0a5b7743778a37065400de14ab
出典データセット
uspto-grants-2000_04
特許番号
US06051577

反応ノート

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