Morpholine → 5-(Morpholinosulfonyl)-2-oxindole
反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>ClCCl>[O:18]1[CH2:19][CH2:20][N:15]([S:2]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][C:9](=[O:14])[CH2:8]3)(=[O:4])=[O:3])[CH2:16][CH2:17]1参加物
4
実験手順
A suspension of 2.3 g of 5-chlorosulfonyl-2-oxindole and 2.2 g of morpholine in 50 mL of dichloromethane was stirred at room temperature for 3 hours. The white precipitate was collected by vacuum filtration, washed with ethyl acetate and hexane and dried under vacuum at 40° C. overnight to give 2.1 g (74% yield) of 5-(morpholinosulfonyl)-2-oxindole.
後処理
- filtrationThe white precipitate was collected by vacuum filtration
- washwashed with ethyl acetate and hexane
- customdried under vacuum at 40° C. overnight
出典と根拠
- ORDレコード
- ord-f8615f01f7b7429184d525a9d4ae6053
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06051593
反応ノート
読み込み中…