4,5-Dimethyl-2-furaldehyde → 3-[(4,5-Dimethyl-furan-2-ylmethyl)-amino]-phthalic acid dimethyl ester

HRID 10047

反応式

HRID 10047 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=O)[O:5][C:6]=1[CH3:7].[CH3:10][O:11][C:12](=[O:29])[C:13]1[C:14](=[C:19]([NH:23]CCCCC)[CH:20]=[CH:21][CH:22]=1)[C:15]([O:17][CH3:18])=[O:16]>>[CH3:10][O:11][C:12](=[O:29])[C:13]1[C:14](=[C:19]([NH:23][CH2:8][C:4]2[O:5][C:6]([CH3:7])=[C:2]([CH3:1])[CH:3]=2)[CH:20]=[CH:21][CH:22]=1)[C:15]([O:17][CH3:18])=[O:16]

参加物

3

反応物 2

HCID 6434064,5-Dimethyl-2-furaldehydeHCID 210401313-Pentylamino-phthalic acid dimethyl ester

生成物 1

HCID 210401303-[(4,5-Dimethyl-furan-2-ylmethyl)-amino]-phthalic acid dimethyl ester収率 75%

実験手順

4,5-Dimethyl-furan-2-carbaldehyde (0.98 ml, 8 mmol) was treated in the same manner as described above for the synthesis of 3-pentylamino-phthalic acid dimethyl ester. The residue (oil) was purified by chromatography (SiO2, 10% ethyl acetate/hexanes) to give 0.95 g (75%) of product as a yellow oil: 1H NMR (CDCl3) δ 7.32 (t, J=8.2 Hz, 1H), 6.97 (bs, 1H), 6.88–6.83 (m, 2H), 5.99 (s, 1H), 4.28 (d, J=5.5 Hz, 2H), 3.86 (s, 3H), 2.17 (s, 3H), 1.87 (s, 3H).

後処理

  1. customThe residue (oil) was purified by chromatography (SiO2, 10% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-b56ed8791a944129a68e40b13317ed46
出典データセット
uspto-grants-2006_08
特許番号
US07091353B2

関連ノート

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