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HRID 1004976作成日：2026年10月26日

2-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthalene → tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-[4-(2-trimethylsilyl-ethoxy-methoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylate

https://huagongshe.com/reaction/1004976

反応式

関与物質

役割名称HCID仕込み量
反応物2-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthaleneHCID 22126529—
反応物tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-hydroxy-piperidine-1-carboxylateHCID 54237291—
生成物tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-[4-(2-trimethylsilyl-ethoxy-methoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylateHCID 86604395—

反応手順

In an analogous manner to that described in Example 1(g), by alkylating tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-hydroxy-piperidine-1-carboxylate with 2-chloromethyl-4-(β-trimethylsilyl-ethoxymethoxy)-naphthalene there was obtained tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-[4-(2-trimethylsilyl-ethoxy-methoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylate as a light yellow oil; MS: 530 [M-(C2H4 +CH2O)]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06051712
出典データセットuspto-grants-2000_04
ORD IDord-7c572eb96df844949ed27a8a2c0f397d
出典メモuspto-grants-2000_04