4-(1,4-Dioxaspiro[4.5]dec-8-ylamino)-3-methoxy-2-methylpyridine hydrochloride → 4-(4-Oxocyclohexylamino)-3-methoxy-2-methylpyridine hydrochloride
反応式
[ClH:1].O1[C:6]2([CH2:11][CH2:10][CH:9]([NH:12][C:13]3[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[C:14]=3[O:20][CH3:21])[CH2:8][CH2:7]2)[O:5]CC1>C(O)=O>[ClH:1].[O:5]=[C:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[CH:18]=[CH:17][N:16]=[C:15]([CH3:19])[C:14]=2[O:20][CH3:21])[CH2:10][CH2:11]1参加物
3
実験手順
27.3 g of 4-(1,4-dioxaspiro[4.5]dec-8-ylamino)-3-methoxy-2-methylpyridine hydrochloride are stirred with 400 ml of formic acid for 4 hours. The residue which remains after concentrating in vacuo is dissolved in methylene chloride and shaken with 2N NaOH. The methylene chloride phase is concentrated, the residue is dissolved in ether and the hydrochloride is precipitated by addition of ethereal HCl. 14 g=90%; m.p.: 115° to 120° C.
後処理
- concentrationafter concentrating in vacuo