Hydrochloric Acid → 1-Benzyl-4-[4-(2-hydroxy-ethyl)-phenyl]-piperidin-4-ol

HRID 1005007ノート

反応式

HRID 1005007 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][O:23]C3CCCCO3)=[CH:17][CH:16]=2)([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C(=O)([O-])O.[Na+]>CO>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:16]=[CH:17][C:18]([CH2:21][CH2:22][OH:23])=[CH:19][CH:20]=2)([OH:14])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 22127334(RS)-1-benzyl-4-[4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-phenyl]-piperidin-4-ol

生成物 1

HCID 149034381-Benzyl-4-[4-(2-hydroxy-ethyl)-phenyl]-piperidin-4-ol収率 84.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 78 g (197 mmol) of (RS)-1-benzyl-4-[4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-phenyl]-piperidin-4-ol in 400 ml of methanol was treated with 470 ml of 2N hydrochloric acid and stirred at room temperature for 5 hours. For the working-up, the reaction solution was poured into 1500 ml of saturated sodium hydrogen carbonate solution and subsequently extracted three times with 1000 ml of ethyl acetate each time. The combined organic phases were dried over sodium sulphate and evaporated under reduced pressure. For purification of the crude substance, a flash chromatography on silica gel using a 95:5 mixture of methylene chloride and methanol as the eluent was carried out. There were obtained 51.6 g (84% of theory) of 1-benzyl-4-[4-(2-hydroxy-ethyl)-phenyl]-piperidin-4-ol as a yellowish solid; MS: 312 (M+H)+.

後処理

  1. extractionsubsequently extracted three times with 1000 ml of ethyl acetate each time
  2. dry with materialThe combined organic phases were dried over sodium sulphate
  3. customevaporated under reduced pressure
  4. customFor purification of the crude substance
  5. additiona flash chromatography on silica gel using a 95:5 mixture of methylene chloride and methanol as the eluent

出典と根拠

ORDレコード
ord-1c6212361cc54554a6ef5ac2b612937a
出典データセット
uspto-grants-2000_04
特許番号
US06051712

反応ノート

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